Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)

Korean society of Clincal Toxicology (대한임상독성학회)
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Association between defoliant exposure and survival to discharge after out-of-hospital cardiac arrest

고엽제 노출과 병원 밖 심정지 후 생존 퇴원과의 연관성

  • Kim, Dong Wook (Department of emergency medicine, Veterans Health Service Medical Center) ;
  • Kye, Yu Chan (Department of emergency medicine, Veterans Health Service Medical Center) ;
  • Lee, Jung Youp (Department of emergency medicine, Veterans Health Service Medical Center) ;
  • Jung, Eui Gi (Department of emergency medicine, Veterans Health Service Medical Center) ;
  • Kim, Dong Sung (Department of emergency medicine, Veterans Health Service Medical Center) ;
  • Choi, Hyun Jung (Department of emergency medicine, Veterans Health Service Medical Center) ;
  • Lee, Young (Veterans Medical Research Institute, Veterans Health Service Medical Center)
  • 김동욱 (중앙보훈병원 응급의학과) ;
  • 계유찬 (중앙보훈병원 응급의학과) ;
  • 이정엽 (중앙보훈병원 응급의학과) ;
  • 정의기 (중앙보훈병원 응급의학과) ;
  • 김동성 (중앙보훈병원 응급의학과) ;
  • 최현정 (중앙보훈병원 응급의학과) ;
  • 이영 (중앙보훈병원 보훈의학연구소)
  • Received : 2020.09.15
  • Accepted : 2021.01.08
  • Published : 2021.06.30
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Abstract

Purpose: We investigated the association between defoliant exposure and survival to discharge after out-of-hospital cardiac arrest. Methods: This is a retrospective case-control study based on the cardiopulmonary resuscitation (CPR) registry. The electronic medical records of out-of-hospital cardiac arrest victims from 6/9/2008 to 12/31/2016 were analyzed statistically. The case patients group had a history of defoliant exposure while the control group did not. Among the 401 victims studied, a total of 110 patients were male out-of-hospital cardiac arrest patients. Baseline characteristics and the parameters involved in cardiac arrest were analyzed and compared between the two groups after propensity score matching. The primary outcome was survival to discharge, and secondary outcomes were sustained return of spontaneous circulation (ROSC) and survival to admission. Results: After propensity score matching a total of 50 patients (case=25, control=25) were analyzed. Primary outcome (survival to discharge) was not significantly different between case and control groups [(OR, 1.759; 95% C.I., 0.491-6.309) and (OR, 1.842; 95% C.I., 0.515-6.593), respectively]. In the subgroup analysis, there were also no significant differences between the control group and subgroups in primary and secondary outcomes according to defoliant exposure severity. Conclusion: There is no statistically significant association between defoliant exposure and survival of out-of-hospital cardiac arrest.

Keywords

Acknowledgement

본 연구는 2017년도 병원 내부연구과제(과제승인번호: VHSMC17005)로 지원을 받아 수행되었음.

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