Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Anti-inflammatory Effects of Low-frequency Stimulator using Superposition of Alternating Microcurrent Wave in the Animal Models

  • Kim, Yoo-Jeong (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Lee, Seong gwang (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Go, Shin Jee (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • An, Suyeon (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Kim, Ye eun (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Kim, Ye in (Department of Clinical Laboratory Science, Catholic University of Pusan) ;
  • Hyun, Kyung-Yae (Department of Clinical Laboratory Science, Dong-Eui University) ;
  • Cho, Dong Shik (Natural Well Tech. Co. Ltd) ;
  • Choi, Go-Eun (Department of Clinical Laboratory Science, Catholic University of Pusan)
  • Received : 2021.06.09
  • Accepted : 2021.06.25
  • Published : 2021.06.30
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Abstract

Treatment techniques that affect homeostasis by non-invasive regulation in peripheral organs will advance disease research. Here, we demonstrate a non-invasive method of conditioning within an organ using a low-frequency stimulator superposition of alternating microcurrent wave in stages. It is first applied to the inflammatory response in H3N2-infected sinusitis mice. To check the progress of the treatment, mice were sacrificed every week for 3 weeks, nasal tissue was removed, and the inflammatory response was investigated through H & E staining. The low-frequency stimulation treatment group was found to alleviate the proliferation of epithelial cells and invasion of inflammatory cells compared to the control group as the passage of treatment time. The reduction of inflammatory cytokines in the nasal lavage fluid was observed in H3N2-infected sinusitis mice treated with of low-frequency stimulation using superposition of alternating microcurrent wave compared to H3N2-infected sinusitis mice after 3 weeks. These data demonstrate that low-frequency stimulation device in the form of using alternating current wave superposition on within organs provides a new method to regulate specific physiological functions. Therefore, it is necessary to prove the inhibitory effect of low-frequency stimulation using alternating current wave superposition on inflammatory diseases by various methods through further studies and clinical studies.

Keywords

Acknowledgement

This research was supported by the Gimhae Biomedical Industry Promotion Agency & Busan Techno-Park (BTP).

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