대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)

  • 제34권3호
  • /
  • Pages.96-113
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  • 2021
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  • 1229-4292(pISSN)
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  • 2508-3619(eISSN)
대한한방부인과학회 (The Society of Korean Medicine Obstetrics and Gynecology)
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자궁내막증식증에서 한약 치료의 효과에 대한 체계적 문헌 고찰 및 메타분석 - 중국 임상 연구를 중심으로

A Systematic Review and Meta-Analysis on the Effect of Herbal Medicine for Endometrial Hyperplasia - Focusing on Chinese Randomised Controlled Trials

  • 유진실 (자생한방병원 한방부인과) ;
  • 박경선 (자생한방병원 한방부인과) ;
  • 안영태 (자생한방병원 한방부인과) ;
  • 조유진 (자생한방병원 한방부인과) ;
  • 강은솔 (자생한방병원 한방부인과) ;
  • 정성엽 (자생한방병원 한방신경정신과) ;
  • 이윤재 (자생의료재단 척추관절연구소)
  • Yu, Jin-Sil (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Park, Kyoung-Sun (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Ahn, Young-Tae (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Cho, Yu-Jin (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Kang, Eun-Sol (Dept. of Korean Obstetrics & Gynecology, Jaseng Hospital of Korean Medicine) ;
  • Jung, Sung-Yub (Dept. of Oriental Neuropsychiatry, Jaseng Hospital of Korean Medicine) ;
  • Lee, Yoon-Jae (Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation)
  • 투고 : 2021.07.16
  • 심사 : 2021.08.27
  • 발행 : 2021.08.27
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초록

Objectives: The purpose of this study is to analyze the effectiveness of herbal medicine that are used for endometrial hyperplasia. Methods: We searched on three databases [PubMed, China national knowledge infrastructure (CNKI), and Oriental medicine advanced searching integrated system (OASIS)] with keywords for Endometrial hyperplasia(English, Korean, and Chinese) and evaluated the risk of bias. Meta-analysis was performed on the selected studies. Results: 15 RCTs were finally selected. According to the analysis, Most of the participants were endometrial hyperplasia without atypia. And the combined therapeutic effects of hormonal medicine and herbal medicine were statistically significant (RR 1.21 [95% CI 1.15, 1.28], P<0.00001), The endometrial thickness tended to be thinner when treated combined therapy. And they also showed improvement on levels of pictorial blood assessment chart (PBAC) and hemoglobin. Also, the therapeutic effects of herbal medicine can be identified as similar to Western medicine, and no superior effects have been confirmed (RR 1.05 [95% CI 0.87, 1.28], P=0.60). Conclusion: The combination Western and herbal medicine was more effective than Western medicine alone treated for endometrial hyperplasia without atypia. Moreover there were also significant improvements in endometrial thickness, PBAC and hemoglobin levels.

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참고문헌

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