DOI QR코드

DOI QR Code

Phytochemical Standardization and Anti-Anxiety (Izterab-e-Nafsani) study of Aftimoon Hindi (Cuscuta reflexa Roxb.) on An Animal Model

  • Ara, Irfat (Regional Research Institute of Unani Medicine, University of Kashmir) ;
  • Kalam, Mohd Afsahul (Regional Research Institute of Unani Medicine, University of Kashmir) ;
  • Maqbool, Mudasir (Department of Pharmaceutical Sciences, University Of Kashmir) ;
  • Zehravi, Mehrukh (Department of Clinical Pharmacy Girls Section, Prince Sattam Bin Abdul Aziz University Alkharj)
  • Received : 2021.05.24
  • Accepted : 2021.08.10
  • Published : 2021.08.31

Abstract

Background: Cuscuta reflexa Roxb is a member of the Cuscutaceae family, and in Unani medicine, it is known as Aftimoon. It is a parasitic plant that can be found growing abundantly on various host plants in India up to 3000 metres in altitude during the rainy season. Unani physicians have been using it for years to cure a variety of illnesses, including psychiatric illnesses like melancholia, schizophrenia, and epilepsy. It has been used to cure hepatitis, palpitations, and skin disorders, among other things. Objective of the study: To evaluate anti-anxiety effect of Cuscuta reflexa Roxb in Swiss Albino mice of either sex. Materials and Methods: A total of 24 Swiss Albino mice weighing 25-35 g were used in this study. Animals were chosen at random and held in their cages for at least 7 days in a standard setting. Group A was given regular saline as a vehicle, Group B was given a hydro alcoholic extract of the lower dose of the test drug, Group C was given a hydro alcoholic extract of the higher dose of the test drug, and Group D was given the standard drug Diazepam 5 mg/kg orally. Aftimoon as hydro alcoholic extract (200 mg/kg and 400 mg/kg body wt.) was given in single and double doses and observed for 7 days. Results: For each parameter in each category, mean and standard deviations were computed. For multiple group comparisons, a one-way ANOVA was used, followed by Turkey's post hoc test. (p<0.05) was used as the significance standard. Conclusion: These results advocate that the Aftimoon as double dose (400 mg/kg body wt.) revealed anti-anxiety effect similar to standard drug.

References

  1. Akbar S. Cuscuta reflexa Roxb (Convolvulaceae). In Handbook of 200 Medicinal Plants, Springer, p.825-830, 2020.
  2. Ansari AP, Ahmed NZ, Ahmed KK & Khan AA. An Insight on Wabai Amrad (Epidemic Diseases) and COVID-19 Like Conditions-Unani Perspective. Int J Cur Res Rev. 2020; 12: 109.
  3. Ara I, Yaqoob S, Bukhari B, Ara N, Raja WY & Maqbool M. Aftimoon Hindi (Cuscuta Reflexa Roxb.): A Miraculous Herb.
  4. Ara I, Yaqoob S, Bukhari B, Raja WY & Maqbool M. International Journal of Modern Pharmaceutical Research.
  5. Ara I, Yaqoob S, Raja WY, Bukhari B, & Maqbool M. Managing Anxiety Disorders: A Short Communication. 2020.
  6. Bandelow B & Michaelis S. Epidemiology of anxiety disorders in the 21st century. Dialogues in clinical neuroscience, 2015; 17: 327.
  7. Bandelow B, Sher L, Bunevicius R, Hollander E, Kasper S, Zohar J, Moller HJ. WFSBP Task Force on Anxiety Disorders & PTSD. Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care. International journal of psychiatry in clinical practice. 2012; 16: 77-84.
  8. Blanco E, Castilla-Ortega E, Miranda R, Begega A, Aguirre JA, Arias JL, Santin LJ. Effects of medial prefrontal cortex lesions on anxiety-like behaviour in restrained and nonrestrained rats. Behavioural brain research. 2009; 201: 338-342.
  9. Bourin M, Petit-Demouliere B, Dhonnchadha BN, Hascoet M. Animal models of anxiety in mice. Fundamental & clinical pharmacology. 2007; 21: 567-574.
  10. Granziera E, Guglieri I, Del Bianco P, Capovilla E, Dona' B, Ciccarese AA, Kilmartin D, Manfredi V, De Salvo GL. A multidisciplinary approach to improve preoperative understanding and reduce anxiety: a randomised study. European Journal of Anaesthesiology (EJA). 2013; 30, 734-742.
  11. Hkm K. Biyaze Kabeer. Vol-1 & 2. Aejaz Publishing Housing. Qarabadeene Majeedi, All India Unani Tibbi Conference, Delhi.
  12. Khan M. IkseerAzam (Urdu Translation by HkMohdKabeeruddin). IdaraKitab al-Shifa, New Delhi, p.836-838, 2011
  13. Kokate C, Purohit A & Gokhale S. Analytical pharmacognosy. Nirali publication. 2005; 30: 199.
  14. Lach G, Schellekens H, Dinan TG & Cryan JF. Anxiety, depression, and the microbiome: a role for gut peptides. Neurotherapeutics. 2018;15: 36-59.
  15. Lowe B, Decker O, Muller S, Brahler E, Schellberg D, Herzog W & Herzberg PY. Validation and standardization of the Generalized Anxiety Disorder Screener (GAD-7) in the general population. Medical care. 2008; 266-274.
  16. Majeedi Q. All India Unani Tibbi Conference. Delhi.1999
  17. Miraj S & Kiani S. A scientific correlation between dystemprament in Unani medicine and diseases: a systematic review. Electronic physician. 2016; 8: 3240.
  18. Mukherjee SS, Kontz M & Reinhardt SK. Detailed design and evaluation of redundant multi-threading alternatives. In Proceedings 29th annual international symposium on computer architecture. 2002; 99-110. IEEE.
  19. Nadkarni KM. [Indian materia medica]; Dr. KM Nadkarni's Indian materia medica: with Ayurvedic, Unani-Tibbi, Siddha, allopathic, homeopathic, naturopathic & home remedies, appendices & indexes. 1. Popular Prakashan. 1996.
  20. Patel S, Sharma V, Chauhan NS & Dixit VK. An updated review on the parasitic herb of Cuscuta reflexa Roxb. Journal of Chinese Integrative Medicine. 2012; 10: 249-255.
  21. Rajaram M, Sofi G, Komala M, Ashok M & Swathi M. AntiAnxiety activity of Kaahu (Lactuca sativa Linn.) and Nilofer (Nympheae Alba Linn.) in animal model. Int J of Unani and integrative Medicine. 2020; 4(2): 05-08
  22. Reddy M. Depression: the disorder and the burden. (SAGE Publications Sage India: New Delhi, India), 2010.
  23. Robichaud M & Dugas MJ. Cognitive-behavioral treatment for generalized anxiety disorder: From science to practice. Routledge. 2019
  24. Sisay M & Gashaw T. Ethnobotanical, ethnopharmacological, and phytochemical studies of Myrtus communis Linn: A popular herb in Unani system of medicine. Journal of evidence-based complementary & alternative medicine. 2017; 22: 1035-1043.
  25. Thomas S, Shrikumar S, Velmurugan C & Kumar B. Evaluation of anxioltic effect of whole plant of "Cuscuta reflexa". World J Pharm Sci. 2015; 4:1245-1253.
  26. Veeresham C, Mamatha R, Babu CP, Srisilam K & Kokate C. Production of taxol and its analogues from cell cultures of Taxus wallichiana. Pharmaceutical biology. 2003; 41: 426-430.
  27. Zehravi M, Maqbool M & Ara I. Polycystic ovary syndrome and reproductive health of women: a curious association. International Journal of Adolescent Medicine and Health. 2021.