The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Systematic Review on the Effects of Herbal Medicine Compared to Amoxicillin in Patients with Upper Respiratory Tract Infection : Focusing on PubMED

상기도 감염 환자의 amoxicillin 대비 한약의 효과에 대한 체계적 문헌고찰 : PubMED를 중심으로

  • Gwak, Seung Yeon (College of Korean Medicine, Sangji University) ;
  • Jeong, Seol (College of Korean Medicine, Sangji University) ;
  • Cho, Eun Ji (College of Korean Medicine, Sangji University) ;
  • Jerng, Ui Min (Department of Internal medicine, College of Korean Medicine, Sangji University)
  • 곽승연 (상지대학교 한의과대학) ;
  • 정설 (상지대학교 한의과대학) ;
  • 조은지 (상지대학교 한의과대학) ;
  • 정의민 (상지대학교 한의과대학 내과학교실)
  • Received : 2021.07.30
  • Accepted : 2021.09.25
  • Published : 2021.09.30
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Abstract

Objective : This study aims to examine the effectiveness and safety of herbal medicines in upper respiratory tract infection by conducting systematic review against amoxicillin. Methods : Relevant randomized controlled trials (RCTs) published by December 2020 were searched in PubMED database. Study selection was conducted according to the PRISMA guideline. The Risk of Bias of the RCTs were evaluated based on the Cochrane criteria. Study selection and bias assessment were conducted independently by two researchers, and the third party was involved if there is a disagreement. Results : Three RCTs were included. Meta-analysis was not performed due to different specific disease and outcome measurements among the included studies. Herbal medicine showed statistically significant improvement in symptoms and endoscopic findings compared to amoxicillin in acute rhinosinusitis. In addition, herbal medicine showed statistically significant improvement in symptoms and a smaller dose of additional antibiotics in acute tonsillitis. However, herbal medicine showed no significant effects compared to amoxicillin in chronic sinusitis patients after functional endoscopic sinus surgery. In terms of adverse events, no significant difference was observed between the herbal medicine group and the amoxicillin group in all studies. Conclusion : Herbal medicine might be more effective than amoxicillin in the treatment of upper respiratory tract infection. Nevertheless, it is hard to clear that conclusion due to the fact that the collected studies were conducted on different specific diseases and herbal medicine, and that the included studies had flaws in the research methodology.

Keywords

Acknowledgement

이 연구는 보건복지부의 지원을 받아 보건산업진흥원 과제(HF20C0002)의 지원을 받아 수행되었습니다.

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