Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Fermented Jeju Soybean Extract Promotes Hair Growth in Human Hair Follicle Organ Culture and Clinical Trial

모낭기관배양과 임상에서 제주푸른콩발효추출물의 육모 효능에 미치는 영향

  • Lee, Yonghee (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Shin, Seung Hyun (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Kim, Sehyun (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Jeong, Gyusang (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Hong, Min Jung (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Park, Hyeokgon (Skincare Research Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Kim, Seung Hun (Skincare Research Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Kim, Eun Joo (Skincare Research Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Kang, Young-Gyu (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Park, Byung Cheol (Department of Dermatology, Dankook Medical College) ;
  • Park, Won Seok (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Kim, Su Na (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center) ;
  • Kim, Hyoung-June (Basic Research & Innovation Division, AMOREPACIFIC Corporation, R&D Center)
  • 이용희 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 신승현 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 김세현 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 정규상 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 홍민정 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 박혁곤 (아모레퍼시픽, R&D센터, 스킨케어연구디비전) ;
  • 김승훈 (아모레퍼시픽, R&D센터, 스킨케어연구디비전) ;
  • 김은주 (아모레퍼시픽, R&D센터, 스킨케어연구디비전) ;
  • 강영규 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 박병철 (단국대학교병원 피부과) ;
  • 박원석 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 김수나 (아모레퍼시픽, R&D센터, 기반혁신연구디비전) ;
  • 김형준 (아모레퍼시픽, R&D센터, 기반혁신연구디비전)
  • Received : 2021.09.23
  • Accepted : 2021.09.29
  • Published : 2021.09.30
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Abstract

Soybean extract is known to play an important role in preventing and treating diseases associated with aging, cancer, obesity, and cardiovascular disease. A recent has revealed that soybean extract has a potent effect on hair growth in in vitro, in vivo, and clinical studies. Recently, it has been reported that their fermented extracts exhibit numerous and high efficacy, as compared to general extracts. However, the underlying mechanisms that induce hair growth after using fermented soybean extract are not well understood. The present study aimed to determine the effects of fermented Jeju soybean (FJS) extract on hair growth, with a focus on the underlying mechanisms similar to those of minoxidil. We conducted in vitro and ex vivo investigations and clinical studies. FJS extract enhanced dermal papilla cell proliferation, VEGF levels, and potassium channel opening. Moreover, it promoted human hair follicle elongation. These effects were comprehensively demonstrated in the clinical results, in which FJS extract-containing shampoo improved hair density after 24 weeks of utilization. Collectively, the results of this study demonstrate that FJS extract promotes hair growth and inhibits hair loss through a mechanism similar to that of minoxidil in hair follicles.

콩 추출물은 노화, 암, 비만 및 심혈관 질환과 같은 질병의 예방 및 치료에 중요한 역할을 하는 것으로 알려져 있다. 최근 연구에 따르면 콩 추출물은 in vitro, in vivo 및 임상 연구에서 모발 성장에 강력한 영향을 미치는 것으로 나타났다. 최근에는 발효추출물이 일반추출물에 비해 다양하고 높은 효능을 나타내는 것으로 보고되고 있다. 그러나 발효된 콩 추출물의 모발 성장을 유도하는 근본적인 매커니즘은 잘 알려져 있지 않다. 본 연구는 미녹시딜과 유사한 기본 매커니즘에 초점을 두고 제주푸른콩발효(FJS)추출물이 모발 성장에 미치는 영향을 확인하였다. 우리는 in vitro, ex vivo와 임상 연구를 수행하였다. 우리의 연구결과, FJS 추출물은 모낭모유두세포증식, VEGF 수준 및 포타슘 채널 활성을 향상시킴을 확인하였다. 이러한 효과는 FJS 추출물 이 함유된 토닉을 사용하였을 때, 24주 후 모발 밀도 개선을 확인한 임상결과에서도 종합적으로 입증되었다. 결론적으로, 본 연구의 결과는 FJS 추출물이 모낭의 미녹시딜과 유사한 매커니즘을 통해 모발 성장을 촉진하고 탈모를 억제한다는 것을 보여준다.

Keywords

References

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