대한의생명과학회지 (Biomedical Science Letters)

  • 제27권3호
  • /
  • Pages.161-169
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  • 2021
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지
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Antioxidant and Anti-inflammatory Effects of Hot Water and Ethanol Extracts from Endemic Plants in Indonesia

  • Hwang, Jin-Woo (Department of Medical Laboratory Science, College of Health Science, Dankook University) ;
  • Choi, Jae-Ho (Department of Medical Laboratory Science, College of Health Science, Dankook University) ;
  • Kang, Sang-Moon (R&D Center, ANPEP Inc.) ;
  • Lee, Sung-Gyu (Department of Medical Laboratory Science, College of Health Science, Dankook University) ;
  • Kang, Hyun (Department of Medical Laboratory Science, College of Health Science, Dankook University)
  • 투고 : 2021.07.27
  • 심사 : 2021.09.16
  • 발행 : 2021.09.30
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초록

The present study, antioxidant and anti-inflammatory effects were measured of 6 endemic plants in Indonesian extracted by hot water or ethanol. The Nipa Fruticans Wurmb ethanol extract (NFWE) and Orthosiphon aristatus ethanol extract (OAE) showed the highest polyphenol and flavonoid contents of 203.70 and 33.70 ㎍/mg, respectively. Antioxidant activity of OAE was highest in DPPH radical scavenging activity (77.49% at 10 ㎍/mL) and ABTS+ radical scavenging activity (93.36% at 10 ㎍/mL). FRAP activity was significantly higher in NFWE than other extracts. Anti-inflammatory effects of 6 endemic plants in Indonesian extracted by hot water or ethanol were examined using nitric oxide (NO) inhibition assays. In the LPS-induced BV2 cells, OAE showed the highest inhibition of NO production without toxicity. The results of this study, suggest that OAE is a potential functional raw material for antioxidant and anti-inflammatory.

키워드

과제정보

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C1234).

참고문헌

  1. Adewole S, Ojewole J. Protective effects of Annona muricata Linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocintreated diabetic rats. Afr J Tradit Complement Altern Med. 2009. 6: 30-41.
  2. Ameer OZ. Orthosiphon stamineus: traditional uses, phytochemistry, pharmacology, and toxicology: a review. J Med Food. 2012. 15: 678-690. https://doi.org/10.1089/jmf.2011.1973
  3. Asare GA, Afriyie D, Ngala RA, et al. Antiproliferative activity of aqueous leaf extract of Annona muricata L. on the prostate, BPH-1 cells, and some target genes. Integr Cancer Ther. 2015. 14: 65-74. https://doi.org/10.1177/1534735414550198
  4. Bae GS, Park SJ. The Anti-inflammatory Effect of Nypa fruticans Wurmb. Fruit on Lipopolysaccharide-induced Inflammatory response on RAW 264.7 cells. Kor J Herbol. 2016. 31: 79-84.
  5. Choi JH, Hwang JW, Lee SG, Heo SH, Kang H. Antioxidant Effect of Hot Water Extracts from 3 Types Indonesia Plants (Hibiscus Petals, Moringa oleifera Gymnosperm, and Nipa Fruticans Wurmb). J Naturopath. 2021. 10: 42-47. https://doi.org/10.33562/JN.2021.10.1.6
  6. Choi JH, Ohk SH. Evaluations on Antioxidant Effect of Water Extract from Graviola Leaves. J Korea Academia-Industrial cooperation Society. 2017. 18: 129-135. https://doi.org/10.5762/KAIS.2017.18.6.129
  7. Choi SS, Yim DS, Lee SK. Radical scavenging activities and protective effects against oxidative damage to DNA of extracts from medicinal plants with known osteoprotective effects. Korean J Pharmacogn, 2009. 40: 143-149.
  8. Dixon AR, McMillen H, Etkin NL. Ferment this: The transformation of noni, a traditional Polynesian medicine (Morinda citrifolia, Rubiaceae). Econ Bot. 1999. 53: 51-68. https://doi.org/10.1007/BF02860792
  9. Dole ckova I, Rarova L, Gruz J, Vondrusova M, Strnad M, Krystof V. Antiproliferative and antiangiogenic effects of flavone eupatorin, an active constituent of chloroform extract of Orthosiphon stamineus leaves. Fitoterapia. 2012. 83: 1000-1007. https://doi.org/10.1016/j.fitote.2012.06.002
  10. Folin O, Denis W. On phosphotungstic-phosphomolybdic compounds as color reagents. J Biol Chem. 1912. 12: 239-243. https://doi.org/10.1016/S0021-9258(18)88697-5
  11. Gavamukulya Y, Abou-Elella F, Wamunyokoli F, AEl-Shemy H. Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pac J Trop Med. 2014. 7: 355-363.
  12. Gopalakrishnan L, Doriya K, Kumar DS. Moringa oleifera: A review on nutritive importance and its medicinal application. Food Sci Human Wellness. 2016. 5: 49-56. https://doi.org/10.1016/j.fshw.2016.04.001
  13. Hamza AA. Ameliorative effects of Moringa oleifera Lam seed extract on liver fibrosis in rats. Food Chem Toxicol. 2009. 48: 345-355. https://doi.org/10.1016/j.fct.2009.10.022
  14. Heinicke RM. The pharmacologically active ingredient of noni. Pac Trop Bot Gard Bull. 1985. 15: 10-14.
  15. Hossain F, Islam A. Utilization of mangrove forest plant: Nipa palm (Nypa fruticans Wurmb.). Am J Agri Forest. 2015. 3: 156-160. https://doi.org/10.11648/j.ajaf.20150304.16
  16. Hou YC, Janczuk A, Wang PG. Current trends in the development of nitric oxide donors. Curr Pharm Des. 1999. 5: 417-441.
  17. Ishola IO, Awodele O, Olusayero AM, Ochieng CO. Mechanisms of analgesic and anti-inflammatory properties of Annona muricata Linn. (Annonaceae) fruit extract in rodents. J Med Food. 2014. 17: 1375-1382. https://doi.org/10.1089/jmf.2013.0088
  18. Kang H. Anti-Oxidative and Anti-Neuroinflammatory Effect of Ethanol Extracts from Walnuts's (Juglans regia L.) Shell. Biomedical Science Letters. 2018. 24: 365-371. https://doi.org/10.15616/BSL.2018.24.4.365
  19. Kim MS, Lee DC, Hong JE, et al. Antimicrobial Effects of Ethanol Extracts from Korean and Indonesian plants. Korean J Food Sci Technol. 2000. 32: 949-958.
  20. Kim YS, Lee SJ, Hwang JW, Kim EH, Park PJ, Jeon BT. Antioxidant Activity and Protective Effects of Extracts from Helianthus tuberosus L. Leaves on t-BHP Induced Oxidative Stress in Chang Cell. J Korean Soc Food Sci Nutr. 2011. 40: 1525-1531. https://doi.org/10.3746/JKFN.2011.40.11.1525
  21. Kim YS, Lee SJ, Hwang JW, Kim EH, Park PJ, Jeong JH. Antioxidant Activities of Extracts from Ligustrum ovalifolium H. Leaves. J Korean Soc Food Sci Nutr. 2011. 40: 1642-1647. https://doi.org/10.3746/JKFN.2011.40.12.1642
  22. Klungboonkrong V, Lamsal BP, Phoungchandang S. Changes and degradation kinetics of some bioactive compounds in dried Orthosiphon aristatus (Java tea) leaves during elevated temperature storage. J Sci Food Agric. 2019. 99: 933-940. https://doi.org/10.1002/jsfa.9268
  23. Kou X, Li B, Olayanju JB, Drake JM, Chen N. Nutraceutical or pharmacological potential of Moringa oleifera Lam. Nutrients. 2018. 10: 1-12. https://doi.org/10.3390/nu10010001
  24. Ku KM, Kim SK, Kang YH. Antioxidant Activity and Functional Components of Corn Silk (Zea mays L.). Korean J Plant Res. 2009. 22: 323-329.
  25. Kwon YR, Youn KS. Antioxidant activity and physiological properties of Moringa (Moringa oleifera Lam.) leaves extracts with different solvents. Korean J Food Preserv. 2014. 21: 831-837. https://doi.org/10.11002/KJFP.2014.21.6.831
  26. Lee GW, Cho YH. Antioxidant Activity of Leaf Extract from Annona muricata. Review of Korea Contents Association. 2016. 14: 43-46.
  27. Lee KW, Je H, Jung TH, et al. Comparison of components and antioxidant activity of cherry, aronia, and maquiberry. Korean J Food Nutr. 2018. 31: 729-736. https://doi.org/10.9799/KSFAN.2018.31.5.729
  28. Lee YR. Antioxidant and α-Amylase Inhibitory Activity of 70% Ethanolic Extract from Morinda citrifolia L. (Noni). Korean J Food Nutr. 2020. 33: 210-214. https://doi.org/10.9799/KSFAN.2020.33.2.210
  29. Lin M, Zhang J, Chen X. Bioactive flavonoids in Moringa oleifera and their health-promoting properties. J Funct Foods. 2018. 47: 469-479. https://doi.org/10.1016/j.jff.2018.06.011
  30. Lopez-Vidana EC, Figueroa IP, Cortes FB, Rojano BA, Ocana AN. Effect of temperature on antioxidant capacity during drying process of mortino (Vaccinium meridionale Swartz). Int J Food Prop. 2017. 20: 294-305. https://doi.org/10.1080/10942912.2016.1155601
  31. Matsushige A, Kotake Y, Matsunami K, Otsuka H, Ohta S, Takeda Y. Annonamine, a new aporphine alkaloid from the leaves of Annona muricata. Chem Pharm Bull (Tokyo). 2012. 60: 257-259. https://doi.org/10.1248/cpb.60.257
  32. Moghadamtousi SZ, Karimian H, Rouhollahi E, Paydar M, Fadaeinasab M, Kadir HA. Annona muricata leaves induce G1 cell cycle arrest and apoptosis through mitochondriamediated pathway in human HCT-116 and HT-29 colon cancer cells. J Ethnopharmacol. 2014. 156: 277-289. https://doi.org/10.1016/j.jep.2014.08.011
  33. Nawwar M, Ayoub N, Hussein S, et al. A flavonol triglycoside and investigation of the antioxidant and cell stimulating activities of Annona muricata Linn. Arch Pharm Res. 2012. 35: 761-767. https://doi.org/10.1007/s12272-012-0501-4
  34. Nieva Moreno MI, Isla MI, Sampietro AR, et al. Comparison of the free radical-scavenging activity of propolis from several regions of Argentina. J Ethnopharmacol. 2000. 71: 109-114 https://doi.org/10.1016/S0378-8741(99)00189-0
  35. Pande M, Naiker M, Mills G, Singh N, Voro T. The Kura files: Qualitative social survey. Pac Health Surveill Response. 2005. 12: 85-93.
  36. Park SH, Kim JM, Kim JH, et al. Antioxidative Effects and Component Analysis of Graviola (Annona muricata) Leaf Extract/Fractions. J Soc Cosmet Sci Korea. 2017. 43: 309-320. https://doi.org/10.15230/SCSK.2017.43.4.309
  37. Paul J, Gnanam R, Jayadeepa RM, Arul L. Anti-cancer activity on Graviola, an exciting medicinal plant extract vs various cancer cell lines and a detailed computational study on its potent anti-cancerous leads. Curr Top Med Chem. 2013. 13: 1666-1673. https://doi.org/10.2174/15680266113139990117
  38. Prasad N, Yang B, Kong KW, et al. Phytochemicals and antioxidant capacity from Nypa fruticans Wurmb. Fruit. Evid Based Complement Alternat Med. 2013. 2013: 1-9. https://doi.org/10.1155/2013/154606
  39. Re R, Pellegrini N, Proteggente A, et al. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med. 1999. 26: 1231-1237. https://doi.org/10.1016/S0891-5849(98)00315-3
  40. Sreelatha S, Jeyachitra A, Padma PR. Antiproliferation and induction of apoptosis by Moringa oleifera leaf extract on human cancer cells. Food Chem Toxicol. 2011. 49: 1270-1275. https://doi.org/10.1016/j.fct.2011.03.006
  41. Sugai K, Watanabe S, Kuishi T, et al. Extremely low genetic diversity of the northern limit populations of Nypa fruticans (Arecaceae) on Iriomote Island. Japan Conserv Genet Resour. 2016. 17: 221-228. https://doi.org/10.1007/s10592-015-0773-6
  42. Sun S, Liu J, Kadouh H, Sun X, Zhou K. Three new anti-proliferative Annonaceous acetogenins with mono-tetrahydrofuran ring from graviola fruit (Annona muricata). Bioorg Med Chem Lett. 2014. 24: 2773-2776. https://doi.org/10.1016/j.bmcl.2014.03.099
  43. Sunder J, Jeyakumar S, Sujatha T, Kundu A. Effect of feeding of morical: A herbal based supplement on production and egg quality in Japanese quail. Adv Anim Vet Sci. 2013. 1: 157-160.
  44. Tabrah FL, Eveleth BM. Evaluation of the effectiveness of ancient Hawaiian medicine. Hawaii Med J. 1966. 25: 223-230.
  45. Tamunaidu P, Saka S. Chemical characterization of various parts of nipa palm (Nypa fruticans). Ind Crop Prod. 2011. 34: 1423-1428. https://doi.org/10.1016/j.indcrop.2011.04.020
  46. Thang TD, Dai DN, Hoi TM, Ogunwande IA. Study on the volatile oil contents of Annona glabra L., Annona squamosa L., Annona muricata L. and Annona reticulata L., from Vietnam. Nat Prod Res. 2013. 27: 1232-1236. https://doi.org/10.1080/14786419.2012.724413
  47. Torres MP, Rachagani S, Purohit V, et al. Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism, Cancer Lett. 2012. 323: 29-40. https://doi.org/10.1016/j.canlet.2012.03.031
  48. Wang MY, Su C. Cancer preventive effect of Morinda citrifolia (noni). Ann NY Acad Sci. 2001. 952: 161-168. https://doi.org/10.1111/j.1749-6632.2001.tb02737.x
  49. Yosoff NA, Ahmad M, AI-Hindi B, Widyawati T, Yam MF, Mahmud R. Aqueous extract of Nypa fruticans Wurmb. Vinegar alleviates postprandial hyperglycemia in normoglycemic rats. Nutrients. 2015. 7: 7012-7026. https://doi.org/10.3390/nu7085320
  50. Zamora R, Vodovotz Y, Billiar TR. Inducible nitric oxide synthase and inflammatory diseases. Mol Med. 2000. 6: 347-373. https://doi.org/10.1007/bf03401781