대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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합병증을 동반하지 않은 2형 당뇨병 환자에 대한 황련해독탕의 혈당 강하 효과에 대한 유효성과 안전성 : 체계적 문헌 고찰과 메타분석

Efficacy and Safety of the Antidiabetic effect of Hwangryunhaedok-tang for Type 2 Diabetes Mellitus Patients without Complications: A Systematic Review and Meta-Analysis

  • 백지수 (대전대학교 한의과대학 신계내과학교실) ;
  • 신선미 (세명대학교 한의과대학 신계내과학교실) ;
  • 신동국 (부천자생한방병원 신경정신과) ;
  • 조충식 (대전대학교 한의과대학 신계내과학교실)
  • Baek, Ji-soo (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University) ;
  • Shin, Seon-mi (Dept. of Internal Medicine, College of Korean Medicine, Se-Myung University) ;
  • Shin, Dong-guk (Dept. of Oriental Neuropsychiatry, Bucheon Jaseng Hospital of Korean Medicine) ;
  • Cho, Chung-sik (Dept. of Internal Korean Medicine, College of Korean Medicine, Dae-Jeon University)
  • 투고 : 2021.08.31
  • 심사 : 2021.09.15
  • 발행 : 2021.09.30
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초록

Objectives: The purpose of this review is to assess the efficacy and safety of Hwangryunhaedok-tang for type 2 diabetes without complications by systemic review and meta-analysis of randomized controlled trials (RCTs). Methods: We searched the following up to March 31. 2021: PubMed, EMBASE, The Cochrane Library, CNKI, CiNii, KISS, KMBASE, OASIS, ScienceON. Data extraction and assessment of Cochrane's risk of bias (RoB) tool were performed by two independent authors, and if there was disagreement between two researchers, it was resolved through the intervention of a third researcher. Results: A total of seven trials are included in this systemic review. The treatment group (Hwangryunhaedok-tang plus conventional treatment) showed more statistically significant effects than did the control group (conventional treatment only) in fasting plasma glucose level, 2-hour postprandial plasma glucose level, glycated hemoglobin A1c, fasting insulin level, and HOMA-IR. There was no significant difference between the treatment group (Hwangryunhaedok-tang alone) and the control group (metformin alone). Conclusion: Hwangryunhaedok-tang might have efficacy and safety in controlling blood sugar level and improving insulin-resistance. However, the number of studies included in the meta-analysis was insufficient, and the Hwangryunhaedok-tang used in the included studies was not standardized. Also, the quality of the involved studies was generally low. Therefore, further studies are needed to determine the efficacy and safety of Hwangryunhaedok-tang treatment for type 2 diabetes mellitus.

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과제정보

본 연구는 보건복지부의 재원으로 한국보건산업진흥원의 보건의료기술 연구개발사업 지원에 의하여 이루어진 것임(HF20C0180).

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