한국식품과학회지 (Korean Journal of Food Science and Technology)

한국식품과학회 (Korean Society of Food Science and Technology)
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미세먼지 흡입 과민성 천식 마우스의 간 조직에서 괭생이모자반 추출물의 항산화 효능

Antioxidant potential of Sargassum horneri extracts in the liver of mice with PM-induced asthma

  • 김효진 (제주대학교 식품생명공학과) ;
  • 김아름 (제주대학교 차세대융봅합과학기술협동과정) ;
  • ;
  • ;
  • 전유진 (제주대학교 수산생명의학과) ;
  • 김현정 (제주대학교 식품생명공학과) ;
  • 지영흔 (제주대학교 차세대융봅합과학기술협동과정)
  • Kim, Hyo Jin (Department of Food Bioengineering, Jeju National University) ;
  • Kim, Areum (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Herath, Kalahe Hewage Iresha Nadeeka Madushani (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Mihindukulasooriya, Suyama Prasansali (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University) ;
  • Jeon, You-Jin (Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University) ;
  • Kim, Hyun Jung (Department of Food Bioengineering, Jeju National University) ;
  • Jee, Youngheun (Interdisciplinary Graduate Program in Advanced Convergence Technology & Science, Jeju National University)
  • 투고 : 2021.04.26
  • 심사 : 2021.08.30
  • 발행 : 2021.10.31
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초록

본 연구에서는 호흡기를 통한 미세먼지 노출이 과민성 천식 마우스 간 조직의 산화적 스트레스에 미치는 영향을 확인하였으며, 이에 대한 괭생이모자반 추출물의 항산화 효과를 평가하였다. 세포막 지질과산화의 최종 산물인 MDA와 항산화 효소인 catalase가 미세먼지 흡입 과민성 천식 마우스의 간 조직에서 증가하였으며 SHE 병행 투여 시 감소하였다. 또한 미세먼지 흡입 과민성 천식 마우스의 간 조직에서 증가한 산화적 DNA 손상 수복효소인 OGG1은 SHE의 병행 투여 시 감소하였다. 결론적으로 괭생이모자반이 미세먼지 흡입 과민성 천식 마우스의 간 조직에서 산화적 스트레스 및 산화적 DNA 손상에 대해 항산화 효과를 나타냈다. 따라서 괭생이모자반이 미세먼지에 의한 산화적 손상을 보호하는 식품 소재로서 활용될 수 있을 것으로 기대된다.

Particulate matter (PM) causes oxidative stress and can rapidly diffuse from the lung to the blood and accumulate in the liver when inhaled. Natural antioxidants can be used to protect against oxidative stress caused by PM. Sargassum horneri, a brown seaweed, possesses antioxidative activity and is a good source of functional foods. Therefore, this study investigated the antioxidant potential of S. horneri extract (SHE) in the livers of PM-induced asthmatic mice. PM inhalation triggered lipid peroxidation and oxidative stress, and SHE treatment attenuated malondialdehyde in the liver of mice with PM-induced asthma. Furthermore, SHE mitigated the increase in catalase activity. Importantly, SHE reduced the activity of 8-oxoguanine glycosylase (OGG1), a DNA repair enzyme. These results suggest that SHE has antioxidant potential for moderating PM-induced oxidative stress and DNA damage in the liver of asthmatic mice.

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과제정보

이 논문은 2021학년도 제주대학교 교육·연구 및 학생지도비 지원에 의해서 연구되었음.

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