Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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Effects of Unripe Rubus Coreanus Extract on Upper Body Obesity: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

미숙과 복분자 추출물의 상체비만 개선 효과: 무작위배정, 이중눈가림, 위약-대조 임상연구

  • Ha, Ki Chan (Healthcare Claims & Management Inc.) ;
  • Kim, Hye Mi (Healthcare Claims & Management Inc.) ;
  • Baek, Hyang Im (Healthcare Claims & Management Inc.) ;
  • Jeong, Da Young (Healthcare Claims & Management Inc.) ;
  • Kim, Eun (Central R&D Center, B&Tech Co., Ltd.) ;
  • Lee, Ki Hoon (Central R&D Center, B&Tech Co., Ltd.) ;
  • Kim, Ha Rim (Department of Korean Medicinal Physiology, College of Korean Medicine, Wonkwang University) ;
  • Kwon, Kang Beom (Department of Korean Medicinal Physiology, College of Korean Medicine, Wonkwang University) ;
  • Kim, Sunoh (Central R&D Center, B&Tech Co., Ltd.) ;
  • Lee, Jung Han (Department of Korean Medicine Rehabilitation, College of Korean Medicine, Wonkwang University)
  • 하기찬 (헬스케어크레임스엔드멘내지멘트(주)) ;
  • 김혜미 (헬스케어크레임스엔드멘내지멘트(주)) ;
  • 백향임 (헬스케어크레임스엔드멘내지멘트(주)) ;
  • 정다영 (헬스케어크레임스엔드멘내지멘트(주)) ;
  • 김은 ((주)비엔텍 중앙연구원) ;
  • 이기훈 ((주)비엔텍 중앙연구원) ;
  • 김하림 (원광대학교 한의과대학 한방생리학교실) ;
  • 권강범 (원광대학교 한의과대학 한방생리학교실) ;
  • 김선오 ((주)비엔텍 중앙연구원) ;
  • 이정한 (원광대학교 한의과대학 한방재활의학교실)
  • Received : 2021.09.06
  • Accepted : 2021.09.29
  • Published : 2021.10.31
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Abstract

Objectives Previously, we demonstrated that a 5% ethanol extract of unripe Rubus coreanus (5-uRCK) and ellagic acid has hypocholesterolemic and antiobesity activity in high-fat diet-fed animals. Therefore, we conducted a clinical study on the anti-obesity effect of 5-uRCK in 140 Korean adults (aged 19-70 years, body mass index (BMI) ≥25 kg/m2). Methods The participants were randomly assigned to two groups and were administered the placebo (n=70) or 5-uRCK extract (800 mg, n=70) daily for 12 weeks. The subjects were instructed to maintain their usual dietary intake and normal physical activity. Anthropometrics, body composition (dual-energy X-ray absorptiometry), and blood parameters were compared between the two groups. Results Average body weight and BMI did not show any significant changes; however, changes in upper body fat mass between the two groups was significantly different, as determined using analysis of covariance adjusted for baseline of percent body fat and drinking units. Moreover, Although not significant, the trunk fat mass and percent trunk fat tended to decrease after 5-uRCK supplementation. There was no significant difference in other laboratory biomarkers between the two groups. All safety parameters were within normal ranges in the both group. Conclusions In the present study, 5-uRCK significantly reduced upper body fat in obese subjects after 12 weeks, which indicates that it may help improve android-type obesity. Furthermore, the supplement is safe and well tolerated.

Keywords

Acknowledgement

본 연구는 과학기술정보통신부가 지원하고 연구개발특구진흥재단이 관리하는 지역의 미래를 여는 과학기술 프로젝트(2021-DD-UP0380)의 연구로 수행하였음.

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