Korean Chemical Engineering Research

The Korean Institute of Chemical Engineers (한국화학공학회)
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Kinetics, Isotherm and Adsorption Mechanism Studies of Letrozole Loaded Modified and Biosynthesized Silver Nanoparticles as a Drug Delivery System: Comparison of Nonlinear and Linear Analysis

  • PourShaban, Mahsa (Department of Biotechnology, Science and research Branch, Islamic Azad University) ;
  • Moniri, Elham (Department of Chemistry, Varamin-Pishva Branch, Islamic Azad University) ;
  • Safaeijavan, Raheleh (Department of Biochemistry and Biophysics, Varamin-Pishva Branch, Islamic Azad University) ;
  • Panahi, Homayon Ahmad (Department of Chemistry, Central Tehran Branch, Islamic Azad University)
  • Received : 2021.01.08
  • Accepted : 2021.08.05
  • Published : 2021.11.01
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Abstract

We prepared and investigated a biosynthesized nanoparticulate system with high adsorption and release capacity of letrozole. Silver nanoparticles (AgNPs) were biosynthesized using olive leaf extract. Cysteine was capped AgNPs to increase the adsorption capacity and suitable interaction between nanoparticles and drug. Morphology and size of nanoparticles were confirmed using transmission electron microscopy (TEM). Nanoparticles were spherical with an average diameter of less than 100 nm. Cysteine capping was successfully confirmed by Fourier transform infrared resonance (FTIR) spectroscopy and elemental analysis (CHN). Also, the factors of letrozole adsorption were optimized and the linear and non-linear forms of isotherms and kinetics were studied. Confirmation of the adsorption data of letrozole by cysteine capped nanoparticles in the Langmuir isotherm model indicated the homogeneous binding site of modified nanoparticles surface. Furthermore, the adsorption rate was kinetically adjusted to the pseudo-second-order model, and a high adsorption rate was observed, indicating that cysteine coated nanoparticles are a promising adsorbent for letrozole delivery. Finally, the kinetic release profile of letrozole loaded modified nanoparticles in simulated gastric and intestinal buffers was studied. Nearly 40% of letrozole was released in simulated gastric fluid with pH 1.2, in 30 min and the rest of it (60%) was released in simulated intestinal fluid with pH 7.4 in 10 h. These results indicate the efficiency of the cysteine capped AgNPs for adsorption and release of drug letrozole for breast cancer therapy.

Keywords

Acknowledgement

The results described in this paper were part of student thesis. The authors thank all laboratory staff of Islamic Azad University, Science and Researches Branch. The authors declare no conflict of interest.

References

  1. Sriharitha, P. J. and Swaroop, H., "A Review on Nanoparticles in Targeted Drug Delivery System, Research & Reviews," Journal of Material Science, 4, 1-6(2006).
  2. Yang, H.-W., Hua, M.-Y., Liu, H.-L., Huang, C.-Y. and Wei, K.-C., "Potential of Magnetic Nanoparticles for Targeted Drug Delivery," Nanotechnology, Science and Applications, 5, 73(2012). https://doi.org/10.2147/NSA.S35506
  3. Jayapriya, E. and Lalitha, P., "Synthesis of Silver Nanoparticles Using Leaf Aqueous Extract of Ocimum Basilicum (L.)," International Journal of ChemTech Research, 5, 2985-2992(2013).
  4. Thakare, S. R. and Ramteke, S. M., "Fast and Regenerative Photocatalyst Material for the Disinfection of E. coli from Water: Silver Nano Particle Anchor on MOF-5," Catalysis Communications, 102, 21-25(2017). https://doi.org/10.1016/j.catcom.2017.06.008
  5. Prusty, K. and Swain, S. K., "Nano Silver Decorated Polyacrylamide/dextran Nanohydrogels Hybrid Composites for Drug Delivery Applications," Materials Science and Engineering C, 85, 130-141(2017). https://doi.org/10.1016/j.msec.2017.11.028
  6. Li, L., et al., "Effect of Stable Antimicrobial Nano-silver Packaging on Inhibiting Mildew and in Storage of Rice," Food Chemistry, 215, 477-482(2017). https://doi.org/10.1016/j.foodchem.2016.08.013
  7. Juling, S., et al., "In vivo Distribution of Nanosilver in the Rat: The Role of Ions and de Novo-formed Secondary Particles," Food Chem Toxicol, 97, 327-335(2016). https://doi.org/10.1016/j.fct.2016.08.016
  8. Wilding, L. A., et al., "Repeated Dose (28-day) Administration of Silver Nanoparticles of Varied Size and Coating Does Not Significantly Alter the Indigenous Murine Gut Microbiome," Nanotoxicology, 10, 513-520(2016). https://doi.org/10.3109/17435390.2015.1078854
  9. Bergin, I. L., et al., "Effects of Particle Size and Coating on Toxicologic Parameters, Fecal Elimination Kinetics and Tissue Distribution of Acutely Ingested Silver Nanoparticles in a Mouse Model," Nanotoxicology, 10, 352-360(2016). https://doi.org/10.3109/17435390.2015.1072588
  10. Shahare, B. and Yashpal, M., "Toxic Effects of Repeated Oral Exposure of Silver Nanoparticles on Small Intestine Mucosa of Mice," Toxicol Mech Methods, 23, 161-167(2013). https://doi.org/10.3109/15376516.2013.764950
  11. Prabhu, S. and Poulose, E. K., "Silver Nanoparticles: Mechanism of Antimicrobial Action, Synthesis, Medical Applications, and Toxicity Effects," International Nano Letters, 2, 32(2012). https://doi.org/10.1186/2228-5326-2-32
  12. Shanmugavadivu, M., Kuppusamy, S. and Ranjithkumar, R., "Synthesis of Pomegranate Peel Extract Mediated Silver Nanoparticles and Its Antibacterial Activity," Am. J. Adv. Drug. Deliv, 2, 174-182(2014).
  13. Khalil, M. M., Ismail, E. H., El-Baghdady, K. Z., Mohamed, D., "Green Synthesis of Silver Nanoparticles Using Olive Leaf Extract and its Antibacterial Activity," Arabian Journal of Chemistry, 7, 1131-1139(2014). https://doi.org/10.1016/j.arabjc.2013.04.007
  14. Cho, K., Wang, X., Nie, S. and Shin, D. M., "Therapeutic Nanoparticles for Drug Delivery in Cancer," Clinical Cancer Research, 14, 1310-1316(2008). https://doi.org/10.1158/1078-0432.ccr-07-1441
  15. Gong, R. and Chen, G., "Preparation and Application of Functionalized Nano Drug Carriers," Saudi Pharmaceutical Journal, 24, 254-257(2016). https://doi.org/10.1016/j.jsps.2016.04.010
  16. Sperling, R. A. and Parak, W. J., "Surface Modification, Functionalization and Bioconjugation of Colloidal Inorganic Nanoparticles, Philosophical Transactions of the Royal Society A: Mathematical," Physical and Engineering Sciences, 368, 1333-1383(2010).
  17. Barzegar-Jalali, M., Adibkia, K., Valizadeh, H., Shadbad, M. R. S., Nokhodchi, A., Omidi, Y., Mohammadi, G., Nezhadi, S. H. and Hasan, M., "Kinetic Analysis of Drug Release from Nanoparticles," Journal of Pharmacy and Pharmaceutical Sciences, 11, 167-177(2008). https://doi.org/10.18433/J3D59T
  18. Panahi, H. A., Nezhati, M. N., Kashkoieh, R. A., Moniri, E., Galaev, I. Y., "Poly[1-(N,N-bis-carboxymethyl) amino-3-allylglycerol-co-dimethylacrylamide] Brushes Grafted Onto Siliceous Support for Preconcentration and Determination of Cobalt (II) in Human Plasma and Environmental Samples," Korean Journal of Chemical Engineering, 30, 1722-1728(2013). https://doi.org/10.1007/s11814-013-0100-1
  19. Geisler, J., Helle, H., Ekse, D., Duong, N. K., Evans, D. B., Nordbo, Y., Aas, T. and Lonning, P. E., "Letrozole is Superior to Anastrozole in Suppressing Breast Cancer Tissue and Plasma Estrogen Levels," Clinical Cancer Research, 14, 6330-6335(2008). https://doi.org/10.1158/1078-0432.ccr-07-5221
  20. Bhatnagar, A. S., "The Discovery and Mechanism of Action of Letrozole," Breast Cancer Research and Treatment, 105, 7-17 (2007). https://doi.org/10.1007/s10549-007-9696-3
  21. Kalaki, Z. A., Safaeijavan, R., Ortakand, M. M., "Biosynthesis of Silver Nanoparticles Using Mentha longifolia (L.) Hudson Leaf Extract and Study its Antibacterial Activity," Archives of Advances in Biosciences, 8, 24-30(2017).
  22. Freitas, A., Mendes, M. and Coelho, G., "Thermodynamic Study of Fatty Acids Adsorption on Different Adsorbents," The Journal of Chemical Thermodynamics, 39, 1027-1037(2007). https://doi.org/10.1016/j.jct.2006.12.016
  23. Langmuir, I., "The Adsorption of Gases on Plane Surfaces of Glass, Mica and Platinum," Journal of the American Chemical Society, 40, 1361-1403(1918). https://doi.org/10.1021/ja02242a004
  24. Hall, K. R., Eagleton, L. C., Acrivos, A. and Vermeulen, T., "Pore-and Solid-diffusion Kinetics in Fixed-bed Adsorption Under Constant-pattern Conditions," Industrial & Engineering Chemistry Fundamentals, 5, 212-223(1966). https://doi.org/10.1021/i160018a011
  25. Hashemian, S., Ardakani, M. K. and Salehifar, H., "Kinetics and Thermodynamics of Adsorption Methylene Blue Onto Tea Waste/CuFe2O4 Composite(2013).
  26. Thabet, M. S. and Ismaiel, A. M., "Sol-Gel γ-Al2O3 Nanoparticles Assessment of the Removal of Eosin Yellow Using: Adsorption, Kinetic and Thermodynamic Parameters," Journal of Encapsulation and Adsorption Sciences, 6, 70(2016). https://doi.org/10.4236/jeas.2016.63007
  27. Ayawei, N., Ekubo, A., Wankasi, D. and Dikio, E., "Adsorption of Congo Red by Ni/Al-CO3: Equilibrium, Thermodynamic and Kinetic Studies," Oriental Journal of Chemistry, 31, 1307-1318 (2015). https://doi.org/10.13005/ojc/310307
  28. Ranjan Sahoo, T. and Prelot, B., "Chapter 7 - Adsorption Processes for the Removal of Contaminants from Wastewater: the Perspective Role of Nanomaterials and Nanotechnology," Nanomaterials for the Detection and Removal of Wastewater Pollutants, 161-222(2020).
  29. Chandran, S. P., Chaudhary, M., Pasricha, R., Ahmad, A. and Sastry, M., "Synthesis of Gold Nanotriangles and Silver Nanoparticles Using Aloevera Plant Extract," Biotechnology Progress, 22, 577-583(2006). https://doi.org/10.1021/bp0501423
  30. Ahmad, N. and Sharma, S., Green synthesis of silver nanoparticles using extracts of Ananas comosus(2012).
  31. Templeton, A. C., Chen, S., Gross, S. M. and R.W. Murray, "Water-soluble, Isolable Gold Clusters Protected by Tiopronin and Coenzyme A Monolayers," Langmuir, 15, 66-76(1999). https://doi.org/10.1021/la9808420
  32. Konicki, W., Aleksandrzak, M., Moszynski, D., Mijowska, E., "Adsorption of Anionic Azo-dyes from Aqueous Solutions Onto Graphene Oxide: Equilibrium, Kinetic and Thermodynamic Studies," Journal of Colloid and Interface Science, 496, 188-200(2017). https://doi.org/10.1016/j.jcis.2017.02.031
  33. Mondal, N., Pal, T. and Ghosal, S., "Development, Physical Characterization, Micromeritics and in vitro Release Kinetics of Letrozole Loaded Biodegradable Nanoparticles," Die Pharmazie-An International Journal of Pharmaceutical Sciences, 63, 361-365(2008).
  34. Dey, S. K., Mandal, B., Bhowmik, M. and Ghosh, L. K., "Development and in vitro Evaluation of Letrozole Loaded Biodegradable Nanoparticles for Breast Cancer Therapy," Brazilian Journal of Pharmaceutical Sciences, 45, 585-591(2009). https://doi.org/10.1590/S1984-82502009000300025