대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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Crizotinib과 한방치료를 병행하여 호전된 ROS1 양성 재발성 폐암 환자 1례

A Case Report on ROS1-positive Recurrent Non-small-cell Lung Cancer Treated with Crizotinib and Korean Medicine

  • 투고 : 2021.09.02
  • 심사 : 2021.10.19
  • 발행 : 2021.10.30
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초록

Objectives: This study examined the case of a patient with ROS1-positive recurrent non-small-cell lung cancer treated with crizotinib and traditional Korean medicine. Methods: The patient was treated with crizotinib from January 20 2021 to May 22 2021, together with Haedogyangpye-tang and Haengso-tang. The tumor size was measured using computed tomography (CT), and adverse events were evaluated according to the National Cancer Institute's Common Terminology Criteria for Adverse Events (NCI-CTCAE) version 5.0. Results: After four months of combined treatment, the sizes of the lymph nodes in the porta hepatis, hepatoduodenal, retrocrural, aortocaval, and para-aortic areas had decreased, and no lymph nodes larger than 1 cm in diameter were observed. The side effects of chemotherapy also improved. Conclusions: This case study suggests that traditional Korean medicine may alleviate the side effects of chemotherapy, improve quality of life, and complement chemotherapy itself.

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참고문헌

  1. Sung HA, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin 2021;71(3):209-49 https://doi.org/10.3322/caac.21660
  2. Lung Cancer. National Cancer Information Center. Available from: URL: https://www.cancer.go.kr/. Published 2021. Accessed January 7, 2021.
  3. Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007;448(7153):561-6. https://doi.org/10.1038/nature05945
  4. Collisson E. Campbell J. Brooks A. Berger A. Lee W, Chmielecki J, et al. Comprehensive molecular profiling of lung adenocarcinoma. Nature 2014;511(7511):543-50. https://doi.org/10.1038/nature13385
  5. Rikova K, Guo A, Zeng Q, Possemato A, Yu J, Haack H, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007;131(6):1190-203. https://doi.org/10.1016/j.cell.2007.11.025
  6. Gainor JF, Varghese AM, Ou SH, Kabraji S, Awad MM, Katayama R, et al. ALK rearrangements are mutually exclusive with mutations in EGFR or KRAS: an analysis of 1,683 patients with non-small cell lung cancer. Clin Cancer Res 2013;19(15):4273-81. https://doi.org/10.1158/1078-0432.CCR-13-0318
  7. Shaw AT, Ou SH, Bang YJ, Camidge DR, Solomon BJ, Salgia R, et al. Crizotinib in ROS1-rearranged non-small-cell lung cancer. N Engl J Med 2014; 371(21):1963-71. https://doi.org/10.1056/NEJMoa1406766
  8. Drilon A, Siena S, Ou SH, Patel M, Ahn MJ, Lee J, et al. Safety and antitumor activity of the multitargeted pan-TRK, ROS1, and ALK inhibitor entrectinib: combined results from two phase I trials(ALKA-372-001 and STARTRK-1). Cancer Discov 2017;7(4):400-9. https://doi.org/10.1158/2159-8290.CD-16-1237
  9. Park JW, Jun HJ, Cho CK, Lee YW. One Case Study of a Non Small Cell Lung Cancer Patient Experiencing Gefitinib Adverse Effects Managed by Traditional Korean Medicine. J of Kor Traditional Oncology 2012;17(1):9-16. https://doi.org/10.15432/JKTO.2012.17.1.009
  10. Shim SH, Seo HJ, Seo HB, Cho IH, Lee C, Kim SY, et al. Traditional Korean Medicine for Non-Small Cell Lung Cancer Patient Undergoing Pembrolizumab Immunotherapy: A Case Report. J Int Korean Med 2019;40(4):709-22 https://doi.org/10.22246/jikm.2019.40.4.709
  11. Li SG, Chen HY, Ou-Yang CS, Wang XX, Yang ZJ, Tong Y, et al. The efficacy of Chinese herbal medicine as an adjunctive therapy for advanced non-small cell lung cancer: a systematic review and meta-analysis. PLoS One 2013;8(2):e57604. https://doi.org/10.1371/journal.pone.0057604
  12. Sohaib A. RECIST rules. Cancer Imaging 2012;12(2):345-6. https://doi.org/10.1102/1470-7330.2012.9011
  13. Watanabe H, Okada M, Kaji Y, Satouchi M, Sato Y, Yamabe Y, et al. [New Response Evaluation Criteria in Solid Tumours-Revised RECIST Guideline(version 1.1).]. Cancer & chemotherapy 2009;36(13):2495-501.
  14. Common Terminology Criteria for Adverse Events (CTCAE). National Cancer Institute.Available from: URL: https://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm. Published 2020. Accessed August 14, 2020.
  15. National Comprehensive Cancer Network. Non-Small Cell Lung Cancer Metastatic. 2021.
  16. Yoon T. Targeted therapy and tailored chemotherapy for advanced non-small cell lung cancer. Korean J Med 2009;77(1):9-17.
  17. Kim KH, Kang HK, Kim SY, Han CW, Park SH, Yun YJ, et al. A Case Report of Korean Medicine Treatment of Non-small Cell Ling Cancer with Pleural Metastasis Following Targeted Chemotherapy with Afatinib. J Int Korean Med 2020;41(6):1255-64. https://doi.org/10.22246/jikm.2020.41.6.1255
  18. Camidge DR, Bang YJ, Kwak EL, Iafrate AJ, Varella-Garcia M, Fox SB, et al. Activity and safety of Crizotinib in patients with ALK-positive non-small-cell lung cancer:updated results from a phase 1study. Lancet Oncol 2012;13(10):1011-9. https://doi.org/10.1016/S1470-2045(12)70344-3
  19. Jung DS, Han JM, Yee J, Kim JY, Gwak HS. Factors Affecting Crizotinib-Induced Hepatotoxicity In Non-small Cell Lung Cancer Patients. Med Oncol 2018;35(12):154. https://doi.org/10.1007/s12032-018-1213-5
  20. Dodd MJ, Miaskowski C, Paul SM. Symptom clusters and their effect on the functional status of patients with cancer. Oncol Nurs Forum 2001;28(3):465-70.
  21. Wu X, Chung VC, Lu P, Poon SK, Hui EP, Lau AY, et al. Chinese Herbal Medicine for Improving Quality of Life Among Nonsmall Cell Lung Cancer Patients: Overview of Systematic Reviews and Network Meta-Analysis. Medicine 2016;95(1):e2410. https://doi.org/10.1097/md.0000000000002410
  22. Li TM, Yu YH, Tsai FJ, Cheng CF, Wu YC, Ho TJ, et al. Characteristics of Chinese herbal medicine usage and its effect on survival of lung cancer patients in Taiwan. Journal of ethnopharmacology 2018;213:92-100. https://doi.org/10.1016/j.jep.2017.10.031
  23. Jeon JC, Kang PG, Park DI, Choi WC. Effects of Several Medicine Herb Prescriptions on Lung Carcinoma Cells. J Int Korean Med 2000;21(4) :621-31.
  24. Chen S, Zhang L. Integrated Chinese and Western Medicine Treatment of Tumor. Beijing: People's Medical Publishing House; 2001, p. 336-41.
  25. Han IS, Kim BW. The Effect of Astragali Radix on Cyclophosphamide-induced Leukocytopenia. Korean J Orientint Med 2006;27(3):579-88.
  26. Lee SO, Seo JH, Lee JW, Yoo MY, Kwon JW, Choi SU, et al. Inhibitory Effect of the Rhizone Extract of Atractylodes japonica on the proloferation of Human Tumor Cell Lines. Kor J Pharmacogn 2005;36(3):201-4.
  27. Park GY, Bae CH, Park SY, Kim JH, Ko WS, Kim YH. Inhibitory Effect of Dendrobium moniliforme on NO and IL-1β Production in LPS-stimulated Macrophages. J Korean Med Ophthalmol Otolaryngol Dermatol 2009;22(3):11-9.
  28. Lee JY, Lee JM, Lee CH, Cho JH, Jang JB, Lee KS. Antitumor and Immunomodulatory Activities of Platycodon grandiflorum. J Korean Obstet Gynecol 2010;23(4):10-9. https://doi.org/10.15204/JKOBGY.2010.23.4.010
  29. Jeong JW, Choi YH. Anti-cancer Properties and Relevant Mechanisms of Cordycepin, an Active Ingredient of the insect Fungus Cordyceps spp. Journal of Life Science 2015;25(5):607-14. https://doi.org/10.5352/JLS.2015.25.5.607
  30. Kim KT, Eom HS, Chi GY. Antiproliferative effect of RST associated with the inhibition of cyclooxygenase-2 expression and prostaglandin E2 release in human lung carcinoma cells. Korean J Oriental Physiology & Pathology 2007;21(4):907-15.
  31. Yang YL, Kim YJ, Kim KH, Oh EG. Separation of Glycoprotein and its Anticancer Immunostimulating Activity from Dried Barks of Slippery Elm [Ulmus parvifolia]. Korean J Biotechnol Bioeng 2001;16(6):547-53.
  32. Kang WJ, Seo UK. Effects of Haengso-tang and Chwiyeon-tang on Expression of Respiratory Mucin Gene and Secretion of Airway Mucus. J Korean Oriental Med 2008;29(3):76-87.
  33. Kasymjanova G, Grossman M, Tran T, Jagoe RT, Cohen V, Pepe C, et al. The potential role for acupuncture in treating symptoms in patients with lung cancer: an observational longitudinal study. CurrOncol 2013;20(3):152-7.
  34. Kim O, Kwon KR. The Study on Acute and Subacute Toxicity and Sarcoma-180 Anti-cancer Effects of Armeniacae amarum semen HerbalAcupuncture(Haeng-In). J of Korean pharmacopuncture institute 2002;5(1):61-79. https://doi.org/10.3831/KPI.2002.5.1.061