Korean Journal of Organic Agriculture (한국유기농업학회지)

Korean Association of Organic Agriculture (한국유기농업학회)
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Effects of Natural Mineral Water on Reflux Esophagitis

역류성 식도염에 대한 천연 미네랄 워터의 효과

  • 추병길 (전북대학교 농업생명과학대학 작물생명과학과)
  • Received : 2021.11.05
  • Accepted : 2021.12.29
  • Published : 2022.02.28
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Abstract

Reflux esophagitis (RE) is a gastroesophageal reflux disease (GERD) caused by repeated reflux of gastric acid into the esophagus. The present study investigated the protective effect of natural mineral water on esophageal injury induced by gastric acid reflux. The cytotoxicity of mineral water was confirmed using Cell viability, proliferation and cytotoxicity assay kit. The protective effect of mineral water on esophageal injury was investigated in RE rat model. The results showed that no cytotoxicity of mineral water was observed in RAW264.7 cells. Mineral water decreased the ratio of esophageal damage, inhibited the increase of inflammatory-protein expression levels and increased the mucosa protection and tight junction proteins expression level in RE control rat. The results suggest that mineral water may have the potential to protect esophageal damage caused by gastric acid reflux and the potential to alleviate reflux esophagitis.

본 연구는 다량 미네랄 6종 및 미량 미네랄 8종이 함유된 천연 미네랄 워터의 기능성을 확인하기 위해 역류성 식도염 유발 동물모델을 이용하여 개선 효과를 분석하였다. RAW264.7에서의 세포 생존율 측정 결과를 통해 미네랄 워터는 세포에 대한 독성이 없음을 확인하였으며, 역류성 식도염 동물모델에서 위 내용물 역류에 의한 식도 손상을 감소시켰으며, 식도 점막 보호 작용으로 인해 세포 연접 단백질 발현을 억제하였다. 따라서, 미네랄 워터의 식도 보호 작용은 조직 내 염증성 단백질 및 점막 재생 관련 단백질을 조절함으로써 나타난 것으로 사료된다. 이러한 연구 결과를 통해, 미네랄 워터의 기능성을 확인함으로써 음용수, 식품 생산 등의 다양한 산업 분야에서의 활용성과 가축 생산에 있어 면역증진 및 염증 관련 질병에 대처할 수 있는 친환경 기능성 사료첨가제로서의 미네랄 워터의 이용 가치를 확인할 수 있었다.

Keywords

References

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