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인지기능 저하와 체내 중금속 10종 간 연관성 분석

Association between Cognitive Decline and Ten Heavy Metals

  • 임채린 (동아대학교 의과대학 예방의학교실) ;
  • 이승호 (동아대학교 의과대학 예방의학교실) ;
  • 서상민 (동아대학교 의과대학 정신건강의학교실) ;
  • 박경원 (동아대학교 의과대학 신경과학교실) ;
  • 김권민 (부산대학교 의학연구소) ;
  • 최병무 (동아대학교 의과대학 정신건강의학교실) ;
  • 김병권 (동아대학교 의과대학 예방의학교실) ;
  • 임현주 (부산광역시 환경보건센터) ;
  • 홍영습 (동아대학교 의과대학 예방의학교실)
  • Chaelyn, Lim (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Seungho, Lee (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Sang Min, Seo (Department of Psychiatry, College of Medicine, Dong-A University) ;
  • Kyung Won, Park (Department of Neurology, College of Medicine, Dong-A University) ;
  • Gwon-Min, Kim (Medical Research Institute, Pusan National University) ;
  • Byeong Moo, Choe (Department of Psychiatry, College of Medicine, Dong-A University) ;
  • Byoung-Gwon, Kim (Department of Preventive Medicine, College of Medicine, Dong-A University) ;
  • Hyun Ju, Lim (Environmental Health Center for Busan, Dong-A University) ;
  • Young-Seoub, Hong (Department of Preventive Medicine, College of Medicine, Dong-A University)
  • 투고 : 2022.12.01
  • 심사 : 2022.12.20
  • 발행 : 2022.12.31

초록

Background: Due to the rapid aging of the South Korean population, neurological diseases such as dementia are increasing. Many studies have reported that the incidence of dementia is associated with environmental factors along with age. Objectives: This study analyzed the association between cognitive function and ten heavy metals in the body: arsenic, aluminum, chromium, manganese, cobalt, nickel, iron, copper, zinc, and lead. Methods: From 2018 to 2019, a total of 120 participants who suffered from cognitive impairment were recruited for this study. Blood and urine samples were collected and analyzed for heavy metal concentrations using an inductively coupled plasma mass spectrometer. Demographic information was obtained through face-to-face questionnaires completed by a trained investigator. Cognitive function was evaluated with the Korean version of the Mini-Mental State Examination and the Korean version of the Boston Name Waiting Test. The associations between cognitive function scores and heavy metal concentrations were analyzed using multiple logistic regression analysis. Results: The average age of the 120 participants was 72.7 years, and 69.2% were female. The mean of the MMSE-K and K-BNT scores were 22.9 and 37.9, respectively. The geometric mean of aluminum (Al) was 8.42 ㎍/L. MMSE-K was associated with iron (Fe), but the significance was removed in the logistic regression based on 24 points. K-BNT was significantly associated with aluminum and the odds ratio for K-BNT above 38 decreased by 45% as the aluminum concentration increased. Conclusions: The association between aluminum and the K-BNT score indicated that aluminum is associated with language-related cognitive decline. Based on this result, further study will be conducted by considering co-exposure effects of heavy metals including aluminum.

키워드

과제정보

본 연구는 환경부·한국환경보건학회 환경보건센터 "2022년 환경보건 전문인력 양성사업(IV)"에서 연구비를 지원받아 동아대학교병원 신경과와 부산시 환경보건센터의 협업으로 수행되었습니다. 진료와 사업수행에 관한 모든 지원에 감사드립니다.

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