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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Stress granules dynamics: benefits in cancer

  • Jeong In, Lee (Department of Biochemistry, Kangwon National University) ;
  • Sim, Namkoong (Department of Biochemistry, Kangwon National University)
  • Received : 2022.08.21
  • Accepted : 2022.10.17
  • Published : 2022.12.31
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Abstract

Stress granules (SGs) are stress-induced subcellular compartments, which carry out a particular function to cope with stress. These granules protect cells from stress-related damage and cell death through dynamic sequestration of numerous ribonucleoproteins (RNPs) and signaling proteins, thereby promoting cell survival under both physiological and pathological condition. During tumorigenesis, cancer cells are repeatedly exposed to diverse stress stimuli from the tumor microenvironment, and the dynamics of SGs is often modulated due to the alteration of gene expression patterns in cancer cells, leading to tumor progression as well as resistance to anticancer treatment. In this mini review, we provide a brief discussion about our current understanding of the fundamental roles of SGs during physiological stress and the effect of dysregulated SGs on cancer cell fitness and cancer therapy.

Keywords

Acknowledgement

We thank Dr. Junsoo Park and Dr. Sungjin Moon for comments on the manuscript. This work was supported by the grant from the National Research Foundation of Korea (NRF-2020R1C1C 1009253) and 2020 Research Grant from Kangwon National University given to SN.

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