Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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Antioxidant, anticoagulant, and α-glucosidase inhibitory effects of mistletoe (Viscum album var. coloratum) extract

겨우살이(Viscum album var. coloratum) 추출물의 항산화, 항응고 및 α-glucosidase 저해 효과

  • Lee, Mi Eun (Department of Chemical Engineering, Chungwoon University) ;
  • Kim, Jung Min (Department of Chemical Engineering, Chungwoon University) ;
  • Song, In Young (Department of Chemical Engineering, Chungwoon University) ;
  • In, Man-Jin (Department of Chemical Engineering, Chungwoon University) ;
  • Kim, Dong Chung (Department of Chemical Engineering, Chungwoon University)
  • Received : 2022.03.08
  • Accepted : 2022.03.18
  • Published : 2022.03.31
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Abstract

Antioxidant, α-glucosidase inhibition, and anticoagulant effects of 80% ethanolic extract from mistletoe (Viscum album var. coloratum) were investigated. The yield and polyphenol content of the mistletoe extract were 30.9±0.4% and 57.6±1.5 mg gallic acid equivalents/g, respectively. The antioxidant effects of the mistletoe extract such as free and cationic radical scavenging ability, nitrite scavenging ability, and reducing power increased in proportion to its concentration. Also the mistletoe extract inhibited the activity of α-glucosidase, and delayed plasma coagulation mainly by inhibiting the extrinsic and common pathways in blood coagulation system.

겨우살이(Viscum album var. coloratum)의 80% 에탄올 추출물의 항산화, α-glucosidase 저해 및 항응고 효과를 확인하였다. 겨우살이 추출물의 수율은 30.9±0.4%이었고, 폴리페놀 함량은 57.6±1.5 mg GAE/g으로 나타났다. 겨우살이 추출물의 농도에 비례하여 유리라디칼 및 양이온라디칼 소거능, 아질산염 소거능, 환원력의 항산화 효과가 증가하였다. 또한 겨우살이 추출물은 α-glucosidase의 활성을 저해하였고, 혈액응고 체계의 외인성 경로와 공통 경로를 주로 저해함으로써 혈장 응고를 억제하였다.

Keywords

Acknowledgement

본 논문은 제1저자의 청운대학교 석사학위논문을 바탕으로 작성 되었습니다.

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