Journal of Oral Medicine and Pain

  • 제47권1호
  • /
  • Pages.62-66
  • /
  • 2022
  • /
  • 2288-9272(pISSN)
  • /
  • 2383-8493(eISSN)
대한안면통증구강내과학회 (Korean Academy of Orofacial Pain and Oral Medicine)
권호 표지
DOI QR코드

DOI QR Code

A Case of Aphthous Stomatitis in a Healthy Adult Following COVID-19 Vaccination: Clinical Reasoning

  • Kim, Hye Kyoung (Department of Orofacial Pain and Oral Medicine, Dankook University College of Dentistry) ;
  • Kim, Mee Eun (Department of Orofacial Pain and Oral Medicine, Dankook University College of Dentistry)
  • 투고 : 2022.01.11
  • 심사 : 2022.03.22
  • 발행 : 2022.03.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Recent case studies raised the possibility that cutaneous and oral mucosal manifestations may be associated with the coronavirus disease 2019 (COVID-19) vaccination. A healthy 43-year-old male presented an acute aphthous stomatitis following Moderna COVID-19 vaccination. This rare case draws attention to a potential etiologic effect for oral mucosal manifestation from COVID-19 vaccination. Further investigation to shed light on prevalence and pathophysiologic association of this oral lesion and COVID-19 vaccination deserve attention.

키워드

과제정보

This case report was supported by a grant from National Research Foundation of Korea (no. 2019R1G1A1004713).

참고문헌

  1. Akintoye SO, Greenberg MS. Recurrent aphthous stomatitis. Dent Clin North Am 2014;58:281-297. https://doi.org/10.1016/j.cden.2013.12.002
  2. Preeti L, Magesh K, Rajkumar K, Karthik R. Recurrent aphthous stomatitis. J Oral Maxillofac Pathol 2011;15:252-256. https://doi.org/10.4103/0973-029X.86669
  3. Kulkarni R, Sollecito TP. COVID-19 vaccination: possible shortterm exacerbations of oral mucosal diseases. Int J Dermatol 2021;60:e335-e336.
  4. Derruau S, Bouchet J, Nassif A, et al. COVID-19 and dentistry in 72 questions: an overview of the literature. J Clin Med 2021;10:779. https://doi.org/10.3390/jcm10040779
  5. Mazur M, Dus-Ilnicka I, Jedlinski M, et al. Facial and oral manifestations following COVID-19 vaccination: a survey-based study and a first perspective. Int J Environ Res Public Health 2021;18:4965. https://doi.org/10.3390/ijerph18094965
  6. Riad A. Oral side effects of COVID-19 vaccine. Br Dent J 2021;230:59. https://doi.org/10.1038/s41415-021-2615-x
  7. Cirillo N. Reported orofacial adverse effects of COVID-19 vaccines: the knowns and the unknowns. J Oral Pathol Med 2021;50:424-427. https://doi.org/10.1111/jop.13165
  8. Riad A, Kassem I, Stanek J, Badrah M, Klugarova J, Klugar M. Aphthous stomatitis in COVID-19 patients: case-series and literature review. Dermatol Ther 2021;34:e14735.
  9. Sinha A, Kumar R, Singh AR. Implication of mass COVID-19 vaccination on dermatology practice in 2021. Dermatol Ther 2021;34:e14765.
  10. Merhy R, Sarkis AS, Kaikati J, El Khoury L, Ghosn S, Stephan F. New-onset cutaneous lichen planus triggered by COVID-19 vaccination. J Eur Acad Dermatol Venereol 2021;35:e729-e730.
  11. Wojcicki AV, O'Flynn O'Brien KL. Vulvar aphthous ulcer in an adolescent after Pfizer-BioNTech (BNT162b2) COVID-19 vaccination. J Pediatr Adolesc Gynecol 2022;35:167-170. https://doi.org/10.1016/j.jpag.2021.10.005
  12. Toor SM, Saleh R, Sasidharan Nair V, Taha RZ, Elkord E. T-cell responses and therapies against SARS-CoV-2 infection. Immunology 2021;162:30-43. https://doi.org/10.1111/imm.13262
  13. Centers for Disease Control and Prevention. Selected adverse events reported after COVID-19 vaccination [Internet]. Atlanta: Centers for Disease Control and Prevention; [cited 2021 Dec 19]. Available from: https://www.cdc.gov/coronavirus/2019-ncov/ vaccines/safety/adverse-events.html.
  14. Singh S, Kumar R, Agrawal B. Adenoviral vector-based vaccines and gene therapies: current status and future prospects. London: IntechOpen; 2018.
  15. Wu RQ, Zhang DF, Tu E, Chen QM, Chen W. The mucosal immune system in the oral cavity-an orchestra of T cell diversity. Int J Oral Sci 2014;6:125-132. https://doi.org/10.1038/ijos.2014.48