Acknowledgement
This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2016R1D1A1B03932018) and Brain Korea 21 Plus (Project number: 22A20130012143).
References
- Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394-424. https://doi.org/10.3322/caac.21492
- Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM. Cancer stem cells--perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 2006;66:9339-44. https://doi.org/10.1158/0008-5472.CAN-06-3126
- Lobo NA, Shimono Y, Qian D, Clarke MF. The biology of cancer stem cells. Annu Rev Cell Dev Biol 2007;23:675-99. https://doi.org/10.1146/annurev.cellbio.22.010305.104154
- Cherciu I, Barbalan A, Pirici D, Margaritescu C, Saftoiu A. Stem cells, colorectal cancer and cancer stem cell markers correlations. Curr Health Sci J 2014;40:153-61. https://doi.org/10.12865/CHSJ.40.03.01
- Sikandar SS, Pate KT, Anderson S, Dizon D, Edwards RA, Waterman ML, Lipkin SM. NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer. Cancer Res 2010;70:1469-78. https://doi.org/10.1158/0008-5472.CAN-09-2557
- Lundberg IV, Edin S, Eklof V, Oberg A, Palmqvist R, Wikberg ML. SOX2 expression is associated with a cancer stem cell state and down-regulation of CDX2 in colorectal cancer. BMC Cancer 2016;16:471. https://doi.org/10.1186/s12885-016-2509-5
- Roy S, Majumdar AP. Signaling in colon cancer stem cells. J Mol Signal 2012;7:11. https://doi.org/10.1186/1750-2187-7-11
- Brabletz S, Schmalhofer O, Brabletz T. Gastrointestinal stem cells in development and cancer. J Pathol 2009;217:307-17. https://doi.org/10.1002/path.2475
- Comstock GW, Alberg AJ, Huang HY, Wu K, Burke AE, Hoffman SC, Norkus EP, Gross M, Cutler RG, Morris JS, et al. The risk of developing lung cancer associated with antioxidants in the blood: ascorbic acids, carotenoids, alpha-tocopherol, selenium, and total peroxyl radical absorbing capacity. Am J Epidemiol 2008;168:831-40. https://doi.org/10.1093/aje/kwn328
- Lin J, Cook NR, Albert C, Zaharris E, Gaziano JM, Van Denburgh M, Buring JE, Manson JE. Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial. J Natl Cancer Inst 2009;101:14-23. https://doi.org/10.1093/jnci/djn438
- Temple NJ, Basu TK. Protective effect of beta-carotene against colon tumors in mice. J Natl Cancer Inst 1987;78:1211-4.
- Pham DN, Leclerc D, Levesque N, Deng L, Rozen R. β,β-carotene 15,15'-monooxygenase and its substrate β-carotene modulate migration and invasion in colorectal carcinoma cells. Am J Clin Nutr 2013;98:413-22. https://doi.org/10.3945/ajcn.113.060996
- Lim JY, Kim YS, Kim KM, Min SJ, Kim Y. B-carotene inhibits neuroblastoma tumorigenesis by regulating cell differentiation and cancer cell stemness. Biochem Biophys Res Commun 2014;450:1475-80. https://doi.org/10.1016/j.bbrc.2014.07.021
- Lee HA, Park S, Kim Y. Effect of β-carotene on cancer cell stemness and differentiation in SK-N-BE(2)C neuroblastoma cells. Oncol Rep 2013;30:1869-77. https://doi.org/10.3892/or.2013.2643
- Min SJ, Lim JY, Kim HR, Kim SJ, Kim Y. Sasa quelpaertensis leaf extract inhibits colon cancer by regulating cancer cell stemness in vitro and in vivo. Int J Mol Sci 2015;16:9976-97. https://doi.org/10.3390/ijms16059976
- Kim Y, Lin Q, Zelterman D, Yun Z. Hypoxia-regulated delta-like 1 homologue enhances cancer cell stemness and tumorigenicity. Cancer Res 2009;69:9271-80. https://doi.org/10.1158/0008-5472.CAN-09-1605
- Kim YS, Gong X, Rubin LP, Choi SW, Kim Y. β-Carotene 15,15'-oxygenase inhibits cancer cell stemness and metastasis by regulating differentiation-related miRNAs in human neuroblastoma. J Nutr Biochem 2019;69:31-43. https://doi.org/10.1016/j.jnutbio.2019.03.010
- Kim E, Shin JH, Seok PR, Kim MS, Yoo SH, Kim Y. Phyllodulcin, a natural functional sweetener, improves diabetic metabolic changes by regulating hepatic lipogenesis, inflammation, oxidative stress, fibrosis, and gluconeogenesis in db/db mice. J Funct Foods 2018;42:1-11. https://doi.org/10.1016/j.jff.2017.12.038
- Puck TT, Marcus PI. Action of X-rays on mammalian cells. J Exp Med 1956;103:653-66. https://doi.org/10.1084/jem.103.5.653
- Kim D, Kim Y, Kim Y. Effects of β-carotene on expression of selected microRNAs, histone acetylation, and DNA methylation in colon cancer stem cells. J Cancer Prev 2019;24:224-32. https://doi.org/10.15430/jcp.2019.24.4.224
- O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-10. https://doi.org/10.1038/nature05372
- Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, De Maria R. Identification and expansion of human colon-cancer-initiating cells. Nature 2007;445:111-5. https://doi.org/10.1038/nature05384
- Ong CW, Kim LG, Kong HH, Low LY, Iacopetta B, Soong R, Salto-Tellez M. CD133 expression predicts for non-response to chemotherapy in colorectal cancer. Mod Pathol 2010;23:450-7. https://doi.org/10.1038/modpathol.2009.181
- Horst D, Scheel SK, Liebmann S, Neumann J, Maatz S, Kirchner T, Jung A. The cancer stem cell marker CD133 has high prognostic impact but unknown functional relevance for the metastasis of human colon cancer. J Pathol 2009;219:427-34. https://doi.org/10.1002/path.2597
- Afify A, Purnell P, Nguyen L. Role of CD44s and CD44v6 on human breast cancer cell adhesion, migration, and invasion. Exp Mol Pathol 2009;86:95-100. https://doi.org/10.1016/j.yexmp.2008.12.003
- Ju SY, Chiou SH, Su Y. Maintenance of the stemness in CD44+ HCT-15 and HCT-116 human colon cancer cells requires miR-203 suppression. Stem Cell Res (Amst) 2014;12:86-100. https://doi.org/10.1016/j.scr.2013.09.011
- Haraguchi N, Ohkuma M, Sakashita H, Matsuzaki S, Tanaka F, Mimori K, Kamohara Y, Inoue H, Mori M. CD133+CD44+ population efficiently enriches colon cancer initiating cells. Ann Surg Oncol 2008;15:2927-33. https://doi.org/10.1245/s10434-008-0074-0
- Tomita H, Tanaka K, Tanaka T, Hara A. Aldehyde dehydrogenase 1A1 in stem cells and cancer. Oncotarget 2016;7:11018-32. https://doi.org/10.18632/oncotarget.6920
- Kanwar SS, Yu Y, Nautiyal J, Patel BB, Majumdar AP. The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Mol Cancer 2010;9:212. https://doi.org/10.1186/1476-4598-9-212
- Li Y, Zhang T, Korkaya H, Liu S, Lee HF, Newman B, Yu Y, Clouthier SG, Schwartz SJ, Wicha MS, et al. Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells. Clin Cancer Res 2010;16:2580-90. https://doi.org/10.1158/1078-0432.CCR-09-2937
- Ryu MJ, Cho M, Song JY, Yun YS, Choi IW, Kim DE, Park BS, Oh S. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem Biophys Res Commun 2008;377:1304-8. https://doi.org/10.1016/j.bbrc.2008.10.171
- van Staveren WC, Solis DY, Hebrant A, Detours V, Dumont JE, Maenhaut C. Human cancer cell lines: experimental models for cancer cells in situ? For cancer stem cells? Biochim Biophys Acta 2009;1795:92-103.
- Reagan-Shaw S, Nihal M, Ahmad N. Dose translation from animal to human studies revisited. FASEB J 2008;22:659-61. https://doi.org/10.1096/fj.07-9574lsf
- Mech-Nowak A, Swiderski A, Kruczek M, Luczak I, Kostecka-Gugala A. Content of carotenoids in roots of seventeen cultivars of Daucus carota L. Acta Biochim Pol 2012;59:139-41.
- Liu C, Wang XD, Bronson RT, Smith DE, Krinsky NI, Russell RM. Effects of physiological versus pharmacological beta-carotene supplementation on cell proliferation and histopathological changes in the lungs of cigarette smoke-exposed ferrets. Carcinogenesis 2000;21:2245-53. https://doi.org/10.1093/carcin/21.12.2245
- Yang CM, Yen YT, Huang CS, Hu ML. Growth inhibitory efficacy of lycopene and β-carotene against androgen-independent prostate tumor cells xenografted in nude mice. Mol Nutr Food Res 2011;55:606-12. https://doi.org/10.1002/mnfr.201000308
- Mannisto S, Yaun SS, Hunter DJ, Spiegelman D, Adami HO, Albanes D, van den Brandt PA, Buring JE, Cerhan JR, Colditz GA, et al. Dietary carotenoids and risk of colorectal cancer in a pooled analysis of 11 cohort studies. Am J Epidemiol 2007;165:246-55. https://doi.org/10.1093/aje/kwk009
- Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A, Keogh JP, Meyskens FL Jr, Valanis B, Williams JH Jr, et al. Risk factors for lung cancer and for intervention effects in CARET, the Beta-Carotene and Retinol Efficacy Trial. J Natl Cancer Inst 1996;88:1550-9. https://doi.org/10.1093/jnci/88.21.1550
- Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 1994;330:1029-35. https://doi.org/10.1056/NEJM199404143301501
- Yan M, Liu Q. Differentiation therapy: a promising strategy for cancer treatment. Chin J Cancer 2016;35:3. https://doi.org/10.1186/s40880-015-0059-x