Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Sesquiterpenoids from the Stem Bark of Aglaia grandis

  • Harneti, Desi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Permatasari, Atika Ayu (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Anisshabira, Amallya (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Naini, Al Arofatus (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Nurlelasari, Nurlelasari (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Mayanti, Tri (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Maharani, Rani (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Safari, Agus (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Hidayat, Ace Tatang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Farabi, Kindi (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Supratman, Unang (Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran) ;
  • Azmi, Mohamad Nurul (School of Chemical Sciences, Universiti Sains Malaysia) ;
  • Shiono, Yoshihito (Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University)
  • Received : 2021.09.01
  • Accepted : 2021.11.23
  • Published : 2022.03.31
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Abstract

Five sesquiterpenoids, 7-epi-eudesm-4(15)-ene,1β,6α-diol (1), 7-epi-eudesm-4(15)-ene,1β,6α-diol (2), saniculamoid D (3), aphanamol I (4), and 4β,10α-dihydroxyaromadendrane (5), were isolated from the stem bark of Aglaia grandis. The compounds' (1-5) chemical structures were identified by spectroscopic data including, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and HRTOFMS, as well as by comparing with the previously reported spectral data. Therefore, this study described the structural elucidation of compounds 1-5 and evaluated their cytotoxic effects against Hela cervical and B16F10 melanoma cells for the first time, but no significant result was discovered.

Keywords

Acknowledgement

The authors are grateful to the Ministry of Education and Culture, Innovative and Research Council, Indonesia, for supporting this investigation financially through the Higher Education Basic Research Grant, No. 1207/UN6.3.1/PT.00/2021 by Desi Harneti and Academic Leadership Grant from Universitas Padjadjaran, Indonesia (No: 1959/UN6.3.1/PT.00/2021 by Unang Supratman.

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