대한의생명과학회지 (Biomedical Science Letters)

  • 제28권4호
  • /
  • Pages.260-275
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  • 2022
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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SAMD13 as a Novel Prognostic Biomarker and its Correlation with Infiltrating Immune Cells in Hepatocellular Carcinoma

  • Hye-Ran, Kim (Department of Biomedical Laboratory Science, Dong-Eui Institute of Technology) ;
  • Choong Won, Seo (Department of Biomedical Laboratory Science, Dong-Eui Institute of Technology) ;
  • Jae-Ho, Lee (Department of Anatomy, Keimyung University School of Medicine) ;
  • Sang Jun, Han (Department of Biotechnology, College of Fisheries Sciences, Pukyong National University) ;
  • Jongwan, Kim (Department of Biomedical Laboratory Science, Dong-Eui Institute of Technology)
  • 투고 : 2022.11.09
  • 심사 : 2022.12.15
  • 발행 : 2022.12.31
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초록

Sterile alpha motif (SAM) domains bind to various proteins, lipids, and RNAs. However, these domains have not yet been analyzed as prognostic biomarkers. In this study, SAM domain containing 13 (SAMD13), a member of the SAM domain, was evaluated to identify a novel prognostic biomarker in various human cancers, including hepatocellular carcinoma (HCC). Moreover, we identified a correlation between SAMD13 expression and immune cell infiltration in HCC. We performed bioinformatics analysis using online databases, such as Tumor Immune Estimation Resource, UALCAN, Kaplan-Meier plotter, LinkedOmics, and Gene Expression Profiling Interactive Analysis2. SAMD13 expression in HCC samples was significantly higher than that in normal liver tissue; additionally, SAMD13 was higher in primary tumors, various stages of cancer and grades of tumor, and status of nodal metastasis. Higher SAMD13 expression was also associated with poorer prognosis. SAMD13 expression positively correlated with CD8+ T cells, CD4+ T cells, B cells, neutrophils, macrophages, and dendritic cells. In the analysis of SAMD13 co-expression networks, positively related genes of SAMD13 were associated with a high hazard ratio in different types of cancer, including HCC. In biological function of SAMD13, SAMD13 mainly include spliceosome, ribosome biogenesis in eukaryote, ribosome, etc. These results suggest that SAMD13 may serve as a novel prognostic biomarker for HCC diagnosis and provide novel insights into tumor immunology in HCC.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) funded by the Korea government (MSIT) (RS-2022-00165637, NRF-2021R1C1C1003333).

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