Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Feline progressive histiocytosis in four cats: case reports

  • Ji-Su, Kim (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • So-Jeong, Yim (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Jae-Hoon, Kim (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) ;
  • Ji-Youl, Jung (College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
  • Received : 2022.09.23
  • Accepted : 2022.12.13
  • Published : 2022.12.31
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Abstract

We describe four cases of feline progressive histiocytosis (FPH) including three females (one intact, two spayed) and one castrated male cat, with a mean age of 5.95 years at diagnosis. Masses were found under the skin of head, lip, neck, and vulva. Histologically, proliferative round cells had ovoid nuclei, foamy eosinophilic cytoplasm, distinct cytoplasmic processes, and numerous mitotic figures. Immunohistochemically, all cases were positive for Iba1 and MHC II (Dako). One case showed cytoplasmic positive staining for E-cadherin. To the best of our knowledge, this is the first documented report of FPH in Korea.

Keywords

Acknowledgement

This research was supported by the 2022 scientific promotion program funded by Jeju National University.

References

  1. Moore PF. Canine and Feline Histiocytic Diseases. In: Meuten DJ, ed. Tumors in Domestic Animals. 5th ed. pp. 322-336, Wiley Blackwell, Ames, 2017.
  2. Moore PF. A review of histiocytic diseases of dogs and cats. Vet Pathol 2014;51:167-184. https://doi.org/10.1177/0300985813510413
  3. Affolter VK, Moore PF. Feline progressive histiocytosis. Vet Pathol 2006;43:646-655.
  4. Busch MD, Reilly CM, Luff JA, Moore PF. Feline pulmonary Langerhans cell histiocytosis with multiorgan involvement.  Vet Pathol 2008;45:816-824. https://doi.org/10.1354/vp.45-6-816
  5. Kraje AC, Patton CS, Edwards DF. Malignant histiocytosis in 3 cats. J Vet Intern Med 2001;15:252-256. https://doi.org/10.1892/0891-6640(2001)015<0252:MHIC>2.3.CO;2
  6. Pinto da Cunha N, Ghisleni G, Scarampella F, Fabbrini F, Sforna M, Cornegliani L, Caniatti M, Avallone G, Moore P, Roccabianca P. Cytologic and immunocytochemical characterization of feline progressive histiocytosis. Vet Clin Pathol 2014;43:428-436.
  7. Coste M, Prata D, Castiglioni V, Minoli L, Etienne-Raffestin CL, Boulouha L, Moreau S, Lagadic M. Feline progressive histiocytosis: a retrospective investigation of 26 cases and preliminary study of Ki67 as a prognostic marker. J Vet Diagn Invest 2019;31:801-808. https://doi.org/10.1177/1040638719884950
  8. Kohler C. Allograft inflammatory factor-1/Ionized calcium-binding adapter molecule 1 is specifically expressed by most subpopulations of macrophages and spermatids in testis. Cell Tissue Res 2007;330:291-302. https://doi.org/10.1007/s00441-007-0474-7
  9. Pierezan F, Mansell J, Ambrus A, Rodrigues Hoffmann A. Immunohistochemical expression of ionized calcium binding adapter molecule 1 in cutaneous histiocytic proliferative, neoplastic and inflammatory disorders of dogs and cats. J Comp Pathol 2014;151:347-351.
  10. Thomas A, Lindsay J, Wilkinson M, Bodmer J. HLA-D region alpha-chain monoclonal antibodies: cross-reaction between an anti-DP alpha-chain antibody and smooth muscle. J Pathol 1988;154:353-363.
  11. Pires I, Alves A, Rodrigues P, Queiroga FL, Lopes CS. E-cadherin expression in canine cutaneous histiocytoma. Vet Rec 2008;163:59-60.
  12. Hirabayashi M, Chambers JK, Sumi A, Harada K, Haritani M, Omachi T, Kobayashi T, Nakayama H, Uchida K. Immunophenotyping of nonneoplastic and neoplastic histiocytes in cats and characterization of a novel cell line derived from feline progressive histiocytosis. Vet Pathol 2020;57:758-773. https://doi.org/10.1177/0300985820953538
  13. Luz FB, Haspar AP, Gaspar NK, Silva MR. Histiocytes and non-langerhans histiocytosis in dermatology. An Bras de Dermatol 2003;78:99-118.  https://doi.org/10.1590/S0365-05962003000100011