Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Neuronal ceroid lipofuscinosis in a Border Collie: a case report

  • Minsu, Seo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Yoonhoi, Koo (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Dongjoon, Choi (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Sanggu, Kim (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University) ;
  • Taesik, Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Yeon, Chae (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Dohee, Lee (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Hakhyun, Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Mhan-Pyo, Yang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University) ;
  • Soochong, Kim (Laboratory of Veterinary Pathology, College of Veterinary Medicine, Chungbuk National University) ;
  • Byeong-Teck, Kang (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University)
  • Received : 2022.07.18
  • Accepted : 2022.11.08
  • Published : 2022.12.31
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Abstract

A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2021R1A2C1012058) and the Basic Research Lab Program (2022R1A4A1025557) through the NRF of Korea, funded by the Ministry of Science and ICT.

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