한국융합학회논문지 (Journal of the Korea Convergence Society)

  • 제13권4호
  • /
  • Pages.653-657
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  • 2022
  • /
  • 2233-4890(pISSN)
  • /
  • 2713-6353(eISSN)
한국융합학회 (Korea Convergence Society)
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댓잎 추출물이 구강미생물에 미치는 항산화 및 항균 효과

Antioxidant and antibacterial effect of bamboo leaves extract on oral bacteria

  • 황혜정 (건양사이버대학교 보건의료복지학과) ;
  • 김도경 (가톨릭대학교 의과대학) ;
  • 강경희 (건양대학교 치위생학과)
  • Hwang, Hye-Jeong (Department of Health & Welfare Management, Konyang Cyber University) ;
  • Kim, Dokyeong (Precision Medicine Research Center, College of Medicine, The Catholic University of Korea) ;
  • Kang, Kyung-hee (Department of Dental Hygiene, Konyang University)
  • 투고 : 2022.03.16
  • 심사 : 2022.04.20
  • 발행 : 2022.04.28
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초록

구강 질환은 전 세계적으로 심각한 건강 및 경제적 부담을 야기하여 사람들의 삶의 질을 크게 저하시킨다. 대표 구강질환인 치아우식증은 S. mutans에 의해 발생한다. 또한, 구강 병원성 미생물에는 면역 반응이 일어나면서 다양한 구강 질환을 유발할 수 있는 지질다당류(lipopolysaccharide, LPS)가 함유되어 있다. 본 연구의 목적은 구강 질환을 조절하기 위해서 대나무 잎 추출물(BLE)의 항산화 및 항균 효과를 조사하는 것이다. THP-1, oral fibroblasts, S mutans 배양액에 댓잎 추출물을 0-8% 농도별로 처리하여 실험을 진행하였다. 그 결과 단핵세포주와 구강섬유아세포에서 BLE 농도에 따른 항산화 효과를 확인하였다. 또한, BLE 농도에 따른 S. mutans의 항균효과를 입증하였다. 따라서 BLE가 구강질환의 예방 또는 치료에 사용될 수 있음을 시사한다.

Oral disease causes a significant health and economic burden worldwide, significantly reducing people's quality of life. Dental caries, a representative oral disease, is caused by S. mutans. Oral pathogenic microorganisms contain lipopolysaccharide (LPS), which can cause an immune response and cause various oral diseases. The purpose of this study was to investigate the antioxidant and antibacterial effects of bamboo leaf extract (BLE) to control oral diseases. THP-1, oral fibroblasts, and S mutans culture medium were treated with bamboo leaf extract at different concentrations of 0-8% to conduct the experiment.. As a result, the antioxidant effect according to the BLE concentration was confirmed in mononuclear cell lines and oral fibroblasts. In addition, the antibacterial effect of S. mutans according to the BLE concentration was demonstrated. Therefore, BLE can be used for the prevention or treatment of oral diseases.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Education) (NRF-2017R1D1A1B03035544).

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