Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Influence of Panax ginseng formulation on skin microbiota: A randomized, split face comparative clinical study

  • Hou, Joon Hyuk (College of Pharmacy, Korea University) ;
  • Shin, Hyunjung (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation) ;
  • Shin, Hyeji (College of Pharmacy, Korea University) ;
  • Kil, Yechan (College of Pharmacy, Korea University) ;
  • Yang, Da Hye (College of Pharmacy, Korea University) ;
  • Park, Mi Kyeong (College of Pharmacy, Korea University) ;
  • Lee, Wonhee (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation) ;
  • Seong, Jun Yeup (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation) ;
  • Lee, Seung Ho (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation) ;
  • Cho, Hye Sun (Korea Ginseng Corporation Research Institute, Korea Ginseng Corporation) ;
  • Yuk, Soon Hong (College of Pharmacy, Korea University) ;
  • Lee, Ki Yong (College of Pharmacy, Korea University)
  • Received : 2021.08.17
  • Accepted : 2021.12.03
  • Published : 2022.03.01
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Abstract

Background: Skin microbiota is important for maintenance of skin homeostasis; however, its disturbance may cause an increase in pathogenic microorganisms. Therefore, we aimed to develop a red ginseng formulation that can selectively promote beneficial bacteria. Methods: The effects of red ginseng formulation on microorganism growth were analyzed by comparing the growth rates of Staphylococcus aureus, S. epidermidis, and Cutibacterium acnes. Various preservatives mixed with red ginseng formulation were evaluated to determine the ideal composition for selective growth promotion of S. epidermidis. Red ginseng formulation with selected preservative was loaded into a biocompatible polymer mixture and applied to the faces of 20 female subjects in the clinical trial to observe changes in the skin microbiome. Results: Red ginseng formulation promoted the growth of S. aureus and S. epidermidis compared to fructooligosaccharide. When 1,2-hexanediol was applied with red ginseng formulation, only S. epidermidis showed selective growth. The analysis of the release rates of ginsenoside-Rg1 and -Re revealed that the exact content of Pluronic F-127 was around 11%. The application of hydrogel resulted in a decrease in C. acnes in all subjects. In subjects with low levels of S. epidermidis, the distribution of S. epidermidis was significantly increased with the application of hydrogel formulation and total microbial species of subjects decreased by 50% during the clinical trial. Conclusion: We confirmed that red ginseng formulation with 1,2-hexanediol can help maintain skin homeostasis through improvement of skin microbiome.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (NRF-2019R1A6A1A03031807).

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