DOI QR코드

DOI QR Code

Evidence and suggestions for establishing vitamin D intake standards in Koreans for the prevention of chronic diseases

  • Kim, Jung Hyun (Major of Food and Nutrition, PaiChai University) ;
  • Park, Hyoung Su (R&D Unit, Maeil Health Nutrition Co., Ltd.) ;
  • Pae, Munkyong (Department of Food and Nutrition, Chungbuk National University) ;
  • Park, Kyung Hee (Department of Family Medicine, Hallym University Sacred Heart Hospital) ;
  • Kwon, Oran (Department of Nutritional Science and Food Management, Graduate Program in System Health Science and Engineering, Ewha Womans University)
  • Received : 2021.12.06
  • Accepted : 2022.03.23
  • Published : 2022.05.20

Abstract

BACKGROUND/OBJECTIVES: Vitamin D is produced in the skin during sun exposure and is also ingested from foods. The role of vitamin D needs to be considered in the prevention and management of various diseases. Moreover, since the majority of Koreans spend their days indoors, becoming susceptible to the risk of vitamin D deficiency. The current study aims to prepare a basis for determining dietary reference intake of vitamin D in Korea, by reviewing the evidence against various diseases and risks. MATERIALS/METHODS: Literature published in Korea and other countries between 2014 and 2018 was prioritized based on their study design and other criteria, and evaluated using the RoB 2.0 assessment form and United States Department of Agriculture Nutrition Evidence Library Conclusion Statement Evaluation Criteria. RESULTS: Of the 1,709 studies, 128 studies were included in the final systematic analysis after screening. To set the dietary reference intakes of vitamin D based on the selected articles, blood 25(OH)D levels and indicators of bone health were used collectively. Blood vitamin D levels and ultraviolet (UV) exposure time derived from the Korean National Health and Nutrition Examination Survey were analyzed to establish the dietary reference intakes of vitamin D for each stage of the life cycle. The adequate intake levels of vitamin D, according to age and gender, were determined to be in the range of 5-15 ㎍/day, and the tolerable upper intake level was established at 25-100 ㎍/day. CONCLUSIONS: The most important variable for vitamin D nutrition is lifestyle. A balanced diet comprising foods with high contents of vitamin D is important, as is vitamin D synthesis after UV exposure. The adequate intake level of vitamin D mentioned in the 2015 Dietary Reference Intakes for Korean (KDRI) remained unchanged in the 2020 KDRI for the management of vitamin D nutrition in Koreans.

Keywords

Acknowledgement

The authors would like to thank the chairs and members of the 2020 Dietary Reference Intakes for Koreans (KDRIs) review committee, and the 6 working subcommittees (age and physique, infants, energy & macronutrients, vitamins, minerals, and applications), for their tremendous efforts in establishing the 2020 KDRI.

References

  1. Courbebaisse M, Cavalier E. Vitamin D in 2020: old pro-hormone with potential effects beyond mineral metabolism. Nutrients 2020;12:3378. https://doi.org/10.3390/nu12113378
  2. Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev 2001;22:477-501. https://doi.org/10.1210/er.22.4.477
  3. Holick MF. McCollum Award Lecture, 1994: vitamin D--new horizons for the 21st century. Am J Clin Nutr 1994;60:619-30. https://doi.org/10.1093/ajcn/60.4.619
  4. Park HM, Kim JG, Choi WH, Lim SK, Kim GS. The vitamin D nutritional status of postmenopausal women in Korea. Korean J Bone Metab 2003;10:47-55.
  5. Yamamoto M, Kawanobe Y, Takahashi H, Shimazawa E, Kimura S, Ogata E. Vitamin D deficiency and renal calcium transport in the rat. J Clin Invest 1984;74:507-13. https://doi.org/10.1172/JCI111448
  6. Deluca HF, Cantorna MT. Vitamin D: its role and uses in immunology. FASEB J 2001;15:2579-85. https://doi.org/10.1096/fj.01-0433rev
  7. Walters MR. Newly identified actions of the vitamin D endocrine system. Endocr Rev 1992;13:719-64. https://doi.org/10.1210/edrv-13-4-719
  8. Lemire JM. Immunomodulatory actions of 1,25-dihydroxyvitamin D3. J Steroid Biochem Mol Biol 1995;53:599-602. https://doi.org/10.1016/0960-0760(95)00106-A
  9. Hamilton B. Vitamin D and human skeletal muscle. Scand J Med Sci Sports 2010;20:182-90. https://doi.org/10.1111/j.1600-0838.2009.01016.x
  10. Ceglia L. Vitamin D and skeletal muscle tissue and function. Mol Aspects Med 2008;29:407-14. https://doi.org/10.1016/j.mam.2008.07.002
  11. Holick MF. Vitamin D deficiency. N Engl J Med 2007;357:266-81. https://doi.org/10.1056/NEJMra070553
  12. Gagnon C, Lu ZX, Magliano DJ, Dunstan DW, Shaw JE, Zimmet PZ, Sikaris K, Grantham N, Ebeling PR, Daly RM. Serum 25-hydroxyvitamin D, calcium intake, and risk of type 2 diabetes after 5 years: results from a national, population-based prospective study (the Australian Diabetes, Obesity and Lifestyle study). Diabetes Care 2011;34:1133-8. https://doi.org/10.2337/dc10-2167
  13. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017-29. https://doi.org/10.1210/jc.2007-0298
  14. Leu M, Giovannucci E. Vitamin D: epidemiology of cardiovascular risks and events. Best Pract Res Clin Endocrinol Metab 2011;25:633-46. https://doi.org/10.1016/j.beem.2011.04.001
  15. Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS. Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008;117:503-11. https://doi.org/10.1161/CIRCULATIONAHA.107.706127
  16. Holick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancers, and cardiovascular disease. Am J Clin Nutr 2004;80:1678S-88S. https://doi.org/10.1093/ajcn/80.6.1678S
  17. Kamen D, Aranow C. Vitamin D in systemic lupus erythematosus. Curr Opin Rheumatol 2008;20:532-7. https://doi.org/10.1097/BOR.0b013e32830a991b
  18. Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Dietary Reference Intakes for Calcium and Vitamin D. Washington, D.C.: National Academies Press; 2011.
  19. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ. Vitamin D3 and calcium to prevent hip fractures in elderly women. N Engl J Med 1992;327:1637-42. https://doi.org/10.1056/NEJM199212033272305
  20. Yamagata E, Yamada Y, Sugihara Y, Komatsu M, Kimura M, Okayama Y. Physical fitness and depression symptoms in community-dwelling elderly women. Nippon Koshu Eisei Zasshi 2013;60:231-40.
  21. Enright PL, McBurnie MA, Bittner V, Tracy RP, McNamara R, Arnold A, Newman ABCardiovascular Health Study. The 6-min walk test: a quick measure of functional status in elderly adults. Chest 2003;123:387-98. https://doi.org/10.1378/chest.123.2.387
  22. Ho RC, Niti M, Kua EH, Ng TP. Body mass index, waist circumference, waist-hip ratio and depressive symptoms in Chinese elderly: a population-based study. Int J Geriatr Psychiatry 2008;23:401-8. https://doi.org/10.1002/gps.1893
  23. Vogelzangs N, Kritchevsky SB, Beekman AT, Newman AB, Satterfield S, Simonsick EM, Yaffe K, Harris TB, Penninx BW. Depressive symptoms and change in abdominal obesity in older persons. Arch Gen Psychiatry 2008;65:1386-93. https://doi.org/10.1001/archpsyc.65.12.1386
  24. Nah EH, Kim S, Cho HI. Vitamin D levels and prevalence of vitamin D deficiency associated with sex, age, region, and season in Koreans. Lab Med Online 2015;5:84-91. https://doi.org/10.3343/lmo.2015.5.2.84
  25. da Costa Santos CM, de Mattos Pimenta CA, Nobre MR. The PICO strategy for the research question construction and evidence search. Rev Lat Am Enfermagem 2007;15:508-11. https://doi.org/10.1590/S0104-11692007000300023
  26. Kwon O, Kim H, Kim J, Hwang J, Lee J, Yoon MO. The development of the 2020 Dietary Reference Intakes for Korean population: lessons and challenges. J Nutr Health 2021;54:425-34. https://doi.org/10.4163/jnh.2021.54.5.425
  27. Chung M, Balk EM, Ip S, Lee J, Terasawa T, Raman G, Trikalinos T, Lichtenstein AH, Lau J. Systematic review to support the development of nutrient reference intake values: challenges and solutions. Am J Clin Nutr 2010;92:273-6. https://doi.org/10.3945/ajcn.2009.29092
  28. Sterne JA, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I, Cates CJ, Cheng HY, Corbett MS, Eldridge SM, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:l4898.
  29. Spill MK, English LK, Raghavan R, Callahan E, Gungor D, Kingshipp B, Spahn J, Stoody E, Obbagy J. Perspective: USDA nutrition evidence systematic review methodology: grading the strength of evidence in nutrition- and public health-related systematic reviews. Adv Nutr 2021;nmab147.
  30. Tuck SP, Datta HK. Osteoporosis in the aging male: treatment options. Clin Interv Aging 2007;2:521-36. https://doi.org/10.2147/CIA.S820
  31. Berger C, Goltzman D, Langsetmo L, Joseph L, Jackson S, Kreiger N, Tenenhouse A, Davison KS, Josse RG, Prior JC, et al. Peak bone mass from longitudinal data: implications for the prevalence, pathophysiology, and diagnosis of osteoporosis. J Bone Miner Res 2010;25:1948-57. https://doi.org/10.1002/jbmr.95
  32. Chung M, Balk EM, Brendel M, Ip S, Lau J, Lee J, Lichtenstein A, Patel K, Raman G, Tatsioni A, et al. Vitamin D and calcium: a systematic review of health outcomes. Evid Rep Technol Assess (Full Rep) 2009;183:1-420.
  33. Priemel M, von Domarus C, Klatte TO, Kessler S, Schlie J, Meier S, Proksch N, Pastor F, Netter C, Streichert T, et al. Bone mineralization defects and vitamin D deficiency: histomorphometric analysis of iliac crest bone biopsies and circulating 25-hydroxyvitamin D in 675 patients. J Bone Miner Res 2010;25:305-12. https://doi.org/10.1359/jbmr.090728
  34. Cranney A, Horsley T, O'Donnell S, Weiler H, Puil L, Ooi D, Atkinson S, Ward L, Moher D, Hanley D, et al. Effectiveness and safety of vitamin D in relation to bone health. Evid Rep Technol Assess (Full Rep) 2007;158:1-235.
  35. Mithal A, Wahl DA, Bonjour JP, Burckhardt P, Dawson-Hughes B, Eisman JA, El-Hajj Fuleihan G, Josse RG, Lips P, Morales-Torres J, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009;20:1807-20. https://doi.org/10.1007/s00198-009-0954-6
  36. WHO Scientific Group on the Prevention and Management of Osteoporosis. Prevention and Management of Osteoporosis: Report of a WHO Scientific Group. Geneva: World Health Organization; 2003.
  37. Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Washington, D.C.: National Academies Press; 2011.
  38. Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clin Proc 2010;85:752-7. https://doi.org/10.4065/mcp.2010.0138
  39. Okazaki R, Ozono K, Fukumoto S, Inoue D, Yamauchi M, Minagawa M, Michigami T, Takeuchi Y, Matsumoto T, Sugimoto T. Assessment criteria for vitamin D deficiency/insufficiency in Japan: proposal by an expert panel supported by the Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research and the Japan Endocrine Society [Opinion]. J Bone Miner Metab 2017;35:1-5. https://doi.org/10.1007/s00774-016-0805-4
  40. Jung SJ, Hwang BY, Jung JH, Kim HW, Jeong KH, Lee DW, Cho SH, Kim HW. Recent trends in serum vitamin D levels among Korean population: Korea National Health and Nutrition Examination Survey 2008-2014. Korean J Clin Geriatr 2018;19:55-62. https://doi.org/10.15656/kjcg.2018.19.1.55
  41. Korea Meteorological Administration. Estimation of exposure time required for vitamin D production in human skin [Internet]. Daejeon: Korea Meteorological Administration; 2016 [cited 2021 June 10]. Available from: http://www.kma.go.kr.
  42. Food and Nutrition Board, Institute of Medicine (US). Dietary Reference Intakes for Calcium and Vitamin D. Washington D.C.: National Academy Press; 2011.
  43. Tamaki J, Iki M, Sato Y, Kajita E, Nishino H, Akiba T, Matsumoto T, Kagamimori SJPOS Study Group. Total 25-hydroxyvitamin D levels predict fracture risk: results from the 15-year follow-up of the Japanese Population-based Osteoporosis (JPOS) cohort study. Osteoporos Int 2017;28:1903-13. https://doi.org/10.1007/s00198-017-3967-6
  44. National Institute of Health and Nutrition of Japan. Dietary Reference Intakes for Japanese. Japan: National Institute of Health and Nutrition of Japan; 2020.
  45. Yu A, Kim J, Kwon O, Oh SY, Kim J, Yang YJ. The association between serum 25-hydroxyvitamin D concentration and consumption frequencies of vitamin D food sources in Korean adolescents. Clin Nutr Res 2013;2:107-14. https://doi.org/10.7762/cnr.2013.2.2.107
  46. Kim MJ. Nutritional status of vitamin D in Korean mothers and their babies and clinical study of vitamin D supplementation in breast-fed infants [doctor's thesis]. Seoul: Seoul National University; 2007.
  47. The Korean Nutrition Society. Dietary Reference Intakes for Koreans. 1st revision. Seoul: The Korean Nutrition Society; 2010.
  48. Ministry of Health and Welfare (KR); The Korean Nutrition Society. Dietary Reference Intakes for Koreans 2015. Sejong: Ministry of Health and Welfare; 2015.
  49. Steenbock H. The induction of growth promoting and calcifying properties in a ration by exposure to light. Science 1924;60:224-5. https://doi.org/10.1126/science.60.1549.224
  50. Food and Drug Administration. Agency information collection activities; submission for office of management and budget review; comment request; food labeling regulations. Fed Regist 2009;74:53743-6.
  51. Rural Development Administration (KR); National Institute of Agricultural Sciences (KR). The Korean food composition database 9.1. Jeonju: Rural Development Administration; 2019 [cited 2021 June 10]. Available from: http://www.koreanfood.rda.go.kr.
  52. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012;367:40-9. https://doi.org/10.1056/NEJMoa1109617
  53. Shimizu Y, Kim H, Yoshida H, Shimada H, Suzuki T. Serum 25-hydroxyvitamin D level and risk of falls in Japanese community-dwelling elderly women: a 1-year follow-up study. Osteoporos Int 2015;26:2185-92. https://doi.org/10.1007/s00198-015-3130-1