Journal of Environmental Science International (한국환경과학회지)

The Korean Environmental Sciences Society (한국환경과학회)
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Cera Flava Improves Behavioral and Dopaminergic Neuronal Activities in a Mouse Model of Parkinson's Disease

황납추출물이 도파민세포 보호효과 및 파킨슨병 행동장애에 미치는 영향

  • Lim, Hye-Sun (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine) ;
  • Moon, Byeong Cheol (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine) ;
  • Park, Gunhyuk (Herbal Medicine Resources Research Center, Korea Institute of Oriental Medicine)
  • 임혜선 (한국한의학연구원 한약자원연구센터) ;
  • 문병철 (한국한의학연구원 한약자원연구센터) ;
  • 박건혁 (한국한의학연구원 한약자원연구센터)
  • Received : 2022.03.23
  • Accepted : 2022.04.28
  • Published : 2022.05.31
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Abstract

Parkinson's Disease (PD) is a chronic neurodegenerative disorder caused by the progressive loss of dopaminergic neurons, leading to decreased dopamine levels in the midbrain. Although the specific etiology of PD is not yet known, oxidative stress, inflammation, and subsequent apoptosis have been proposed to be closely related to PD pathophysiology. Cera Flava (CF) is a natural extract obtained from beehives and is isolated through the heating, compression, filtration, and purification of beehives. CF has been used in traditional medicines for its various clinical and pharmacological effects. However, its effects on neurodegenerative diseases are unknown. Therefore, we investigated the effects of CF against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD in mice and explored the underlying mechanism of action. In MPTP-induced PC12 cells, CF protected NADH dehydrogenase activity and inhibited lactate dehydrogenase. In the mouse model, CF promoted recovery from movement impairments, prevented dopamine depletion, and protected against MPTP-induced dopaminergic neuronal degradation. Moreover, CF downregulated glial and microglial activation. Taken together, our results suggest that CF improves behavioral impairments and protects against dopamine depletion in MPTP-induced toxicity by inhibiting glial and microglial activation.

Keywords

Acknowledgement

본 연구는 한국한의학연구원 '지속가능한 한약표준자원 활용기술 개발'(KSN2021320) 사업 및 한국연구재단 '미활용 생물자원의 연구기반 구축 및 활성화 연구: 동물성 자원 중심'(NRF-2020R1I1A2073003)의 지원으로 수행되었다.

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