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Diagnosis and Management of Post-Partum Hemorrhage Caused by Acquired Hemophilia A: A Case Report

  • Rashid, Nawshirwan G. (Hiwa Hemato-Oncology Center, Kurdistan Region of Iraq KRI) ;
  • Amin, Shaema Salih (Hiwa Hemato-Oncology Center, Kurdistan Region of Iraq KRI) ;
  • Abdulqader, Aveen M. Raouf (Department of Medical Laboratory Sciences (MLS), American University of Iraq-Sulymaniyah (AUIS))
  • 투고 : 2022.03.03
  • 심사 : 2022.03.23
  • 발행 : 2022.06.30

초록

Acquired hemophilia A (AHA) is an uncommon autoimmune bleeding disorder in which autoantibodies that affect the functions of factor VIII (FVIII) are present in the blood. The initial diagnosis of AHA is difficult as the presentations of AHA differ from those of congenital hemophilia A. Moreover, the treatment of AHA is more complex due to the presence of autoantibodies against FVIII. Here, we present a case report of postpartum AHA, to increase the perception and knowledge regarding the recognition and management of such cases. We present a young female with the chief complaint of vaginal bleeding and upper arm ecchymosis. Laboratory results exhibited isolated prolonged activated partial thromboplastin time (APTT) and FVIII inhibitors. The patient was treated with corticosteroids, FVIII concentrates, and a bypassing agent. In conclusion, unexplained postpartum bleeding, unmanageable with basic hemostatic measures, should lead to clinical suspicion of an acquired bleeding disease.

키워드

과제정보

We greatly thank the Laboratory staff of Sulaymaniyah Hiwa hemato-oncology Center for their enormous participation and cooperation. Very special thanks and appreciation to management staff of the center for their tremendous role, fruitful ideas, advices, and collaboration.

참고문헌

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