Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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The Relationship between Parkinson's Disease and Acute Myocardial Infarction in Korea : A Nationwide Longitudinal Cohort Study

  • Sheen, Seung Hun (Department of Neurosurgery, CHA Bundang Medical Center, CHA University) ;
  • Hong, Je Beom (Department of Neurosurgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine) ;
  • Kim, Hakyung (Genome & Health Big Data Branch, Department of Public Health, Graduate School of Public Health, Seoul National University) ;
  • Kim, Jimin (Cornell University) ;
  • Han, In-bo (Department of Neurosurgery, CHA Bundang Medical Center, CHA University) ;
  • Sohn, Seil (Department of Neurosurgery, CHA Bundang Medical Center, CHA University)
  • Received : 2021.07.29
  • Accepted : 2021.10.20
  • Published : 2022.07.01
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Abstract

Objective : The goal of the following statewide age and gender-coordinated cohort study in Korea is to find out if there is a link between acute myocardial infarction (AMI) and Parkinson's disease (PD). Methods : Utilizing the National Health Insurance Sharing Service cohort, patient data were collected. Six thousand four hundred seventy-five individuals with PD were distinguished by utilizing the International Classification of Diseases 10 code G20 and have enrolled in the PD group. The number of participants decreased to 5259 after excluding 1039 patients who were hospitalized less than one time or who visited an outpatient clinic less than twice. Then, 26295 individuals were selected as part of the control group after case control matching was conducted through 1 : 5 age- and gender-coordinated matching. The Cox proportional hazard regression analysis and Kaplan-Meier method were utilized to analyze the likelihood of AMI in PD. Results : After controlling for age and gender, the hazard ratio of AMI in the PD group was 3.603 (95% confidence interval [CI], 2.837-4.577). After that, the following hazard ratio of AMI in the PD group was modified against for co-morbid medical disorders, resulting in 3.551 (95% CI, 2.795-4.511). According to a subgroup analysis, in males and females aged <65 and aged ≥65 and in the non-diabetes and diabetes, hypertension and non-hypertension, dyslipidemia and non-dyslipidemia subgroups, the AMI incidence rates were dramatically higher in the PD group compared to that of the control. Conclusion : Individuals with PD have a greater chance of AMI, according to this cross-national study.

Keywords

Acknowledgement

The National Research Foundation of Korea's (NRF) Basic Science Research Program, supported by the Ministry of Education (NRF-2021R1I1A3058902), assisted the following nationwide longitudinal study. Furthermore, an endowment from the ICT, Ministry of Science, and future Planning (NRF-2020R1F1A1069875) was given to support our study.

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