Nuclear Engineering and Technology

Korean Nuclear Society (한국원자력학회)
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Performance prediction of gamma electron vertex imaging (GEVI) system for interfractional range shift detection in spot scanning proton therapy

  • Kim, Sung Hun (Center for Proton Therapy, National Cancer Center) ;
  • Jeong, Jong Hwi (Center for Proton Therapy, National Cancer Center) ;
  • Ku, Youngmo (Department of Nuclear Engineering, Hanyang University) ;
  • Jung, Jaerin (Department of Nuclear Engineering, Hanyang University) ;
  • Kim, Chan Hyeong (Department of Nuclear Engineering, Hanyang University)
  • Received : 2020.07.10
  • Accepted : 2021.12.20
  • Published : 2022.06.25
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Abstract

The maximum dose delivery at the end of the beam range provides the main advantage of using proton therapy. The range of the proton beam, however, is subject to uncertainties, which limit the clinical benefits of proton therapy and, therefore, accurate in vivo verification of the beam range is desirable. For the beam range verification in spot scanning proton therapy, a prompt gamma detection system, called as gamma electron vertex imaging (GEVI) system, is under development and, in the present study, the performance of the GEVI system in spot scanning proton therapy was predicted with Geant4 Monte Carlo simulations in terms of shift detection sensitivity, accuracy and precision. The simulation results indicated that the GEVI system can detect the interfractional range shifts down to 1 mm shift for the cases considered in the present study. The results also showed that both the evaluated accuracy and precision were less than 1-2 mm, except for the scenarios where we consider all spots in the energy layer for a local shifting. It was very encouraging results that the accuracy and precision satisfied the smallest distal safety margin of the investigated beam energy (i.e., 4.88 mm for 134.9 MeV).

Keywords

Acknowledgement

This research was supported by the National Cancer Center Grants (NCC-2110390-2), Korea.

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