The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Comparison of the Effectiveness of Herbal Medicine Eye Drops on Conjunctivitis : A Systematic Literature Review and Meta-Analysis

결막염에 대한 한방 점안액의 효과 비교 : 체계적 문헌 고찰과 메타 분석

  • Lim, Hui-Yeong (Dept. of korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University) ;
  • Kim, Jee-Hee (Dept. of korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University) ;
  • Ko, Woo-Shin (Dept. of korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University) ;
  • Yoon, Hwa-Jung (Dept. of korean Medicine Ophthalmology & Otolaryngology & Dermatology, Clinical Korean Medicine, Dong-Eui University)
  • 임희영 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 김지희 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 고우신 (동의대학교 한의과대학 안이비인후피부과학 교실) ;
  • 윤화정 (동의대학교 한의과대학 안이비인후피부과학 교실)
  • Received : 2022.07.11
  • Accepted : 2022.08.02
  • Published : 2022.08.25
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Abstract

Objectives : This study was conducted to find out the effectiveness and safety of herbal medicine eye drops on conjunctivitis. Methods : We searched randomized controlled trials on conjunctivitis through 10 DBs from the start to April 27, 2022. Study collection and data extraction, and evaluation of risk of bias were conducted by two independent researchers. The evaluation of the risk of bias in included RCTs was carried out by using Cochrane risk-of-bias tool. And the data synthesis was conducted by using Review Manager(RevMan, ver.5.4). Results : Total of 106 studies are researched and 7 studies of them are finally included. 1. The herbal medicine eye drops are more effective on than the western medicine eye drops, but the heterogeneity was very high. So we conducted sensitivity analysis and compared to the herbal medicine eye drops and the western medicine eye drops, the total effective rate was higher in the herbal medicine eye drops and the heterogeneity was somewhat reduced. 2. In the subgroup analysis, Fufang Xiongdan eye drops and Houttuynia cordata Thunb eye drops are more effective than the western medicine. It may represent substantial heterogeneity. 3. In the subgroup analysis, the herbal medicine eye drops are more effective than antibiotic and antiviral eye drops on acute bacterial conjunctivitis, but showed high heterogeneity. On the other hand, the herbal medicine eye drops are more effective than antibiotic and antiviral eyed drops on acute viral conjuctivitis and showed low heterogeneity. 4. In the subgroup analysis, we compared the effectiveness of herbal and western medicine eye drops according to total effectiveness rate evaluation methods. When comparing the studies calculating the total effective rate by the sum of 'Cured', 'Significantly Impaired', and 'Improved', the effective rate of the herbal medicine eye drops was higher than that of the western medicine eye drops, and the heterogeneity was very low. 5. In most studies, side effects of herbal medicine eye drops were absent or mild. Conclusions : This study shows that herbal medicine eye drops may be more effective than western medicine eye drops and have safety. But further researches are needed to resolve the heterogeneity of this study.

Keywords

References

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