Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Bioprospecting of Endophytic Fungi as Promising Anti-MRSA Agents

  • Wei, Yee-Min (Chemistry Section, School of Distance Education, Universiti Sains Malaysia) ;
  • Tan, Joo-Shun (School of Industrial Technology, Universiti Sains Malaysia) ;
  • Tang, Hock-Wei (School of Industrial Technology, Universiti Sains Malaysia) ;
  • Tong, Woei-Yenn (Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology) ;
  • Leong, Chean-Ring (Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Bioengineering Technology) ;
  • Tan, Wen-Nee (Chemistry Section, School of Distance Education, Universiti Sains Malaysia)
  • Received : 2022.02.26
  • Accepted : 2022.08.16
  • Published : 2022.09.30
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Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are needed to combat against bacterial resistance. Endophytic fungi are crucial reservoirs of novel bioactive metabolites. In particular, the secondary metabolites show promising therapeutic potential, notably, antibacterial. This review discussed the emerging potential of endophytic fungi as anti-MRSA agents. The ecological sources of endophytic fungi were discussed with the synthesis of bioactive metabolites. The mode of antibacterial actions was elucidated to give a better understanding of the mechanisms involved. This review may serve as an important reference for future discovery and developments of anti-MRSA agents from endophytic fungi.

Keywords

Acknowledgement

This research was funded by the Ministry of Higher Education Malaysia for Fundamental Research Grant Scheme with Project Code: FRGS/1/2018/STG01/USM/02/3. Yee-Min Wei would like to thank Universiti Sains Malaysia for the award of Graduate Student Financial Assistance (GRA-ASSIST).

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