Journal of Animal Reproduction and Biotechnology (한국동물생명공학회지)

The Korean Society of Animal Reproduction and Biotechnology (한국동물생명공학회)
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Various expression patterns of pregnancy-associated plasma protein-A

  • Jeon, Eunjeong (Dairy Science Division, National Institute of Animal Science, RDA) ;
  • Lee, Jihwan (Dairy Science Division, National Institute of Animal Science, RDA) ;
  • Son, Junkyu (Dairy Science Division, National Institute of Animal Science, RDA) ;
  • Kim, Doosan (Dairy Science Division, National Institute of Animal Science, RDA) ;
  • Lim, Dajeong (Animal Genome & Bioinformatics, National Institute of Animal Science, RDA) ;
  • Han, Man-Hye (Dairy Science Division, National Institute of Animal Science, RDA) ;
  • Hwang, Seongsoo (Dairy Science Division, National Institute of Animal Science, RDA)
  • Received : 2022.08.02
  • Accepted : 2022.08.10
  • Published : 2022.09.30
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Abstract

Pregnancy-associated plasma protein-A (PAPP-A) is known as an important biomarker for fetal abnormality during first trimester and has a pivotal role in follicle development and corpus luteum formation. And also, it is being revealed that an expression of PAPP-A in various cells and tissues such as cancer and lesion area. PAPP-A is the major IGF binding protein-4 (IGFBP-4) protease. Cleavage of IGFBP-4 results in loss of binding affinity for IGF, causing increased IGF bioavailability for proliferation, survival, and migration. Additionally, PAPP-A can be used as a promising therapeutic target for healthy longevity. Despite growing interest, almost nothing is known about how PAPP-A expression is regulated in any tissue. This review will focus on what is currently known about the zinc metalloproteinase, PAPP-A, and its role in cells and tissues. PAPP-A is expressed in proliferating cells such as fetus in uterus, granulosa cells in follicle, dermis in wound, cancer cells, and Sertoli cells in testis. They have common characteristics of proliferation faster than normal cells with stimulating IGFs action and inhibiting IGFBPs. The PAPP-A functions and expression studies in livestock have not yet been conducted much. Further studies are needed to use PAPP-A as a marker for healthy longevity in animal science.

Keywords

Acknowledgement

This work was supported by a grant from the "Cooperative Research Program for Agriculture Science & Technology Development (Project No. PJ01681301)" and 2022 the RDA Fellowship Program of National Institute of Animal Science, Rural Development Administration, Republic of Korea.

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