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A Case Report of Recurrent Cervical Intraepithelial Neoplasia Treated by Korean Traditional Medicine and Mistletoe Extract Inject

미슬토 추출물 투여와 병행한 한방치료를 통해 호전된 재발성 자궁경부상피내종양 증례보고

  • Ko, Eun-Bin (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Park, Nam-Gyeong (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Choi, Min-Young (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Jin-Moo (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Chang-Hoon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jang, Jun-Bock (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Hwang, Deok-Sang (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 고은빈 (경희대학교 대학원 임상한의학과) ;
  • 박남경 (경희대학교 대학원 임상한의학과) ;
  • 최민영 (경희대학교 대학원 임상한의학과) ;
  • 이진무 (경희대학교 대학원 임상한의학과) ;
  • 이창훈 (경희대학교 대학원 임상한의학과) ;
  • 장준복 (경희대학교 대학원 임상한의학과) ;
  • 황덕상 (경희대학교 대학원 임상한의학과)
  • Received : 2022.10.14
  • Accepted : 2022.11.25
  • Published : 2022.11.25

Abstract

Objectives: The purpose of this study is to report the improvement of recurrent cervical intraepithelial neoplasia (CIN) and chief complaint including dysmenorrhea, premenstrual syndrome after Korean medicine treatment. Methods: The patient who diagnosed CIN even after undergoing two times of loop electrosurgical excision procedure (LEEP) and complained dysmenorrhea with premenstrual syndrome was treated by acupuncture, moxibustion and herbal medicine as Ojeok-san-gami-bang along with mistletoe extract injection (Abnobaviscum®). The effect of treatment was evaluated by the results of liquid based cytology and HPV genotyping. Other symptoms were evaluated according to the patient's subjective complaint. Results: Before the treatment, the result of cytology was low grade squamous intraepithelial lesion and a low-risk group for HPV was detected. At the first examination after treatment, cytology showed negative for intraepithelial lesion or malignancy and the HPV genotyping was negative. The result showed negative findings in 3 consecutive follow-up tests. In addition, the chief complaint and general conditions were improved. Conclusion: This study shows that the recurrent cervical intraepithelial neoplasia (CIN) was improved after the Korean traditional treatment and it can be effective medical alternatives or options for patients receiving mistletoe injection during follow-up.

Keywords

References

  1. Bray F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. https://doi.org/10.3322/caac.21492
  2. National Center Information Cancer. Annual report of cancer statistics in Korea in 2019 [cited May 23 2022]. Available from:URL:https://www.cancer.go.kr
  3. Korean Society of Obstetrics and Gynecology. Gynecology. 6th edition. Paju:Koonja. 2021:140, 365-99, 771.
  4. Ostor AG. Natural history of cervical intraepithelial neoplasia: a critical review. Int J Gynecol Pathol. 1993;12(2):186-92. https://doi.org/10.1097/00004347-199304000-00018
  5. McCredie MR, et al. Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncol. 2008;9(5):425-34. https://doi.org/10.1016/S1470-2045(08)70103-7
  6. Addis IB, Hatch KD, Berek JS. Intraepithelial disease of the cervix, vagina, and vulva. In: Berek JS, editor. Berek & Novak's gynecology. 14th ed. Philadelphia:Lippincott Williams & Wilkins. 2007:561-600.
  7. Zielinski GD, et al. HPV testing and monitoring of women after treatment of CIN 3: review of the literature and meta-analysis. Obstet Gynecol Surv. 2004;59(7):543-53. https://doi.org/10.1097/00006254-200407000-00024
  8. Verguts J, et al. Prediction of recurrence after treatment for high-grade cervical intraepithelial neoplasia: the role of human papillomavirus testing and age at conisation. British Journal of Obstetrics and Gynaecology. 2006;113(11):1303-7. https://doi.org/10.1111/j.1471-0528.2006.01063.x
  9. Alonso I, et al. High-risk cervical epithelial neoplasia grade 1 treated by loop electrosurgical excision procedure: follow-up and value of human papillomavirus testing. American Journal of Obstetrics and Gynecology. 2007;197(4):359.e1-6. https://doi.org/10.1016/j.ajog.2007.08.071
  10. Lima MIM, et al. Cervical intraepithelial neoplasia recurrence after conization in HIV-positive and HIV-negative women. International Journal of Gynaecology and Obstetrics. 2009;104(2):100-4. https://doi.org/10.1016/j.ijgo.2008.10.009
  11. Kocken M, et al. Risk of recurrent high-grade cervical intraepithelial neoplasia after successful treatment: a long-term multi-cohort study. The Lancet Oncology. 2011;12(5):441-50. https://doi.org/10.1016/S1470-2045(11)70078-X
  12. Bogani G, et al. Recurrence rate after loop electrosurgical excision procedure (LEEP) and laser Conization: A 5-year follow-up study. Gynecologic Oncology. 2020;159(3):636-41. https://doi.org/10.1016/j.ygyno.2020.08.025
  13. Strander B, et al. Long term risk of invasive cancer after treatment for cervical intraepithelial neoplasia grade 3: population based cohort study. BMJ. 2007;335(7629):1077-80. https://doi.org/10.1136/bmj.39363.471806.be
  14. Heo KJ, A Study of External Treatment on the obstetric and gynecologic diseases, Daegu Haany University doctoral dissertation. 2007.
  15. Yoo JE, Lee JY, Yoon YJ. A Review on Korean Traditional Medicine Research against Cervical Dysplasia - Focused on Studies of Cervical Cancer and Cervical Dysplasia. J Korean Obstet Gynecol. 2013;26(4):191-203. https://doi.org/10.15204/JKOBGY.2013.26.4.191
  16. Lee SJ, et al. Herbal Medicine for Cervical Intraepithelial Neoplasia After Loop Electrosurgical Excision Procedure: A Systematic Review and Meta-Analysis. J Korean Obstet Gynecol. 2020;33(2):44-62. https://doi.org/10.15204/JKOBGY.2020.33.2.044
  17. Lee E, Lee KY, Yu BK. 4 Cases of Traditional Korean Medicine Treatment for Patients with Surgical Margin Positive after LEEP in Cervical Intraepithelial Neoplasia. J Physiol & Pathol Korean Med. 2020;34(3):149-58. https://doi.org/10.15188/kjopp.2020.06.34.3.149
  18. van Hamont D, et al. Long-term follow-up after large-loop excision of the transformation zone: evaluation of 22 years treatment of high-grade cervical intraepithelial neoplasia. Int J Gynecol Cancer. 2006;16(2):615-9. https://doi.org/10.1111/j.1525-1438.2006.00404.x
  19. Hormuzd A. Katki, et al. Five-year risk of recurrence after treatment of CIN 2, CIN 3, or AIS: performance of HPV and Pap cotesting in posttreatment management. Journal of Lower Genital Tract Disease. 2013;17(5suppl):78-84.
  20. Trottier H, et al. HPV infection and re-infection in adult women: the role of sexual activity and natural immunity. Cancer Res. 2010;70(21):8569-77. https://doi.org/10.1158/0008-5472.CAN-10-0621
  21. Carter JJ, et al. Comparison of human papillomavirus types16, 18, and 6 capsid antibody responses following incident infection. J Infect Dis. 2000;181(6):1911-9. https://doi.org/10.1086/315498
  22. Kim MK, No JH, Song YS. Human Papillomavirus Vaccine. J Korean Med Assoc. 2009;52(12):1180-6. https://doi.org/10.5124/jkma.2009.52.12.1180
  23. Ghaem-Maghami S, et al. Incomplete excision of cervical intraepithelial neoplasia and risk of treatment failure: a meta-analysis. Lancet Oncol. 2007;8(11):985-93. https://doi.org/10.1016/S1470-2045(07)70283-8
  24. The Society of Korean Medicine Obstetrics and Gynecology. Korean medicine Obstetrics & Gyenecology (Vol 2). 4th rev. Seoul:Euiseongdang. 2021:401.
  25. Lee YJ. Antimetastatic Effects of Ojeoksan by Immunomodulation. KyungHee University doctoral dissertation. 2012.
  26. Lee MJ, et al. Activation of Immune System & Antimetastatic Effects of Ojeok-san by Oral Administration. J Korean Obstet Gynecol. 2014;27(2):34-45. https://doi.org/10.15204/JKOBGY.2014.27.2.034
  27. Won HW, et al. Study of Developmental New Anti-cancer Prescription form Herbs of the activation of blood and the elimination of blood stasis. Korean J Oriental Physiology & Pathology. 2002;16(3):409-20.
  28. Han JS, Park HS. The Effects of Anti-cancer and Immune Response of Lonicerae Flos Herbal-acupuncture. The Journal of Korean Acupuncture & Moxibustion Society. 2006;23(4):205-18.
  29. Park JY, Park HS. Experimental Studies on Antimetastatic and Immunomodulating Effects of Patriniae Radix Herbalacupuncture. The Journal of Korean Acupuncture & Moxibustion Society. 2006;23(4):187-203.
  30. So MS. Effect of Taraxacum mongolieum Hand-Mass on Proliferation of Breast Cancer Cells and Nitric Oxide Production. J Korean Health & Fundamental Med Sci. 2009;2(3):128-31.
  31. Lee TH. Sa-am-do-in-chim-gu-yo-gyeol. Seoul:Haenglim. 1975:243.
  32. Textbook Compilation Committee of Korean Acupunture and Moxibustion Medicine. Acupuncture Medicine. 1st rev. ed. Seoul:Hanmi Medical Publishing Co. 2016:105, 113.
  33. Thies A, et al. Influence of mistletoe lectins and cytokines induced by them on cell proliferation of human melanoma cells in vitro. Toxicology. 2005;207(1):105-16. https://doi.org/10.1016/j.tox.2004.09.009
  34. Schaller G, Urech K, Giannattasio M. Cytotoxicity of different viscotoxins and extracts from the European subspecies of Viscum album L. Phyther Res. 1998;10(6):473-7. https://doi.org/10.1002/(SICI)1099-1573(199609)10:6<473::AID-PTR879>3.0.CO;2-Q
  35. Melo MNO, et al. Phenolic compounds from Viscum album tinctures enhanced antitumor activity in melanoma murine cancer cells. Saudi Pharm J. 2018;26(3):311-22. https://doi.org/10.1016/j.jsps.2018.01.011
  36. Delebinski CI, et al. A natural combination extract of Viscum album L. containing both triterpene acids and lectins is highly effective against AML in vivo. PLoS ONE. 2015;10(8):e0133892. https://doi.org/10.1371/journal.pone.0133892
  37. Choi OB. The importance of clinical mistletoe cancer therapy and korean mistletoe pharmacopuncture preparation development and application possibility for oriental medicine. Journal of Pharmacopuncture. 2009;12(1):77-89. https://doi.org/10.3831/KPI.2009.12.1.077
  38. Jin YJ, Shin KS, Ha JY. Case of Remission of Progressive Breast Cancer Treated by Capecitabine with Integrative Medicine Therapy. J Kor Traditional Oncology. 2014;19(1):43-51. https://doi.org/10.15432/JKTO.2014.19.1.43
  39. Yang JS, et al. A Case Report on the Therapeutic Effect of Integrated Cancer Therapy for Glioblastoma Multiforme. J Int Korean Med. 2022;43(2):320-5. https://doi.org/10.22246/jikm.2022.43.2.320