The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology (한방안이비인후피부과학회지)

The Society of Korean Medicine Ophthalmology, Otolaryngology & Dermatology (대한한방안이비인후피부과학회)
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Analysis of Randomized Controlled Trial Study of Korean Herbal Medicine Treatment for Acne

여드름 한약 치료의 무작위 대조군 임상연구에 관한 분석

  • Lee, Ma-Eum (Chung Sung Mi Korean Medicine Clinic) ;
  • Kwon, Kang (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Pusan National University Hospital) ;
  • Jee, Seon-Young (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Daegu Hanny University) ;
  • Hwangbo, Min (Dep. of Oriental Ophthalmology and Otolaryngology and Dermatology, Daegu Hanny University) ;
  • Kim, Chul-Yun (Saengki Korean Medicine Clinic Pusan Seomyeon Branch) ;
  • Seo, Hyung-Sik (Department of Ophthalmology, Otolaryngology and Dermatology of Korean Medicine, Pusan National University Hospital)
  • 이마음 (정성미 한의원) ;
  • 권강 (부산대학교한방병원 한방안이비인후피부과) ;
  • 지선영 (대구한의대 부속 포항한방병원 한방안이비인후피부과) ;
  • 황보민 (대구한의대 부속 대구한방병원 한방안이비인후피부과) ;
  • 김철윤 (생기한의원 부산 서면점) ;
  • 서형식 (부산대학교한방병원 한방안이비인후피부과)
  • Received : 2022.09.27
  • Accepted : 2022.11.09
  • Published : 2022.11.25
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Abstract

Objectives : The review was conducted to validate the effectiveness of herbal medicines on acne. Methods : Randomized controlled trials(RCTs) reporting the effects of herbal medicine treatment on acne were searched through seven electronic databases from the time of application of the material to October 2021. Cochrane Collaboration's Risk of Bias was used to assess the risk of bias. Analysis was performed using Review Manager 5.4 and R 4.1.0 Meta, Metafor program. Results : 34 RCTs was selected and meta-analysis was performed with 30 studies. The inflammatory lesion count of the herbal medicine(MD=0.29, 95% CI:-0.59-0.01, p<0.01, I2=80%) and the non inflammatory lesion count of herbal medicine(MD=-0.30, 95% CI:-0.70-0.10, p<0.01, I2=78%) were seen. The score of IGA(RR=1.43, 95% CI:0.90-2.27, p<0.91, I2=0%), VISIA(MD=0.36, 95% CI:0.21-0.51, p=0.07, I2=40%), effective rate(RR=1.23, 95% CI:1.05-1.44, p<0.01, I2=98%), DLQI(MD : 0.59, 95% CI:0.14-1.04, p=0.07, I2=63%) and recurrence rate(RR=0.36, 95% CI:0.23-0.58, p=0.73, I2=0%) were seen. The effective rate of herbal medicine were statistically higher that of the control group(WM)(RR=1.19, 95% CI:1.04-1.37, p<0.01, I2=97%). As a result of dividing the treatment groups into OHM, EHM, and OEHM, the EHM group(RR=1.17, 95% CI:0.79-1.72, p<0.01, I2=99%) showed the most statistically significant effect. The overall risk of bias of the included studies was some concerns. No serious adverse effects were observed. Conclusions : This review found the effectiveness of herbal medicine for acne.

Keywords

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