Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지
DOI QR코드

DOI QR Code

Treatment of canine CD3+/CD21+/CD45- T-zone lymphoma with chlorambucil and prednisolone in two dogs: case reports

  • Hee-Tae Park (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Jeong-Min Lee (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Hyeon-A Bae (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Do-Hyeon Yu (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Dong-In Jung (Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) ;
  • Kun-Ho Song (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University) ;
  • Joong-Hyun Song (Department of Veterinary Internal Medicine, College of Veterinary Medicine, Chungnam National University)
  • Received : 2023.10.04
  • Accepted : 2023.11.20
  • Published : 2023.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Canine T-zone lymphoma (TZL) is an indolent form of T-cell lymphoma. Conservative management is usually recommended; however, chemotherapy may be considered for symptomatic or progressive cases. Herein, we describe two dogs with generalized peripheral lymphadenopathy and peripheral blood lymphocytosis at presentation. One dog presented with gross lesions on the tongue. Flow cytometric immunophenotyping and cytological examinations demonstrated findings consistent with those of TZL. Chemotherapy with chlorambucil and prednisolone was administered, which resulted in improvement of the condition without any adverse events. Chemotherapy with chlorambucil may be considered as an appropriate choice for treating canine TZL.

Keywords

Acknowledgement

This study was supported by the National Research Foundation of Korea, funded by a grant from the Korean Government (NRF-2022R1G1A10036821131482092640101). This study is also supported by the Basic Science Research Program through the NRF, funded by the Ministry of Education (RS-2023-0021971031482092640001).

References

  1. Moore AS. Treatment of T cell lymphoma in dogs. Vet Rec 2016;179:277.
  2. Martini V, Marconato L, Poggi A, Riondato F, Aresu L, Cozzi M, Comazzi S. Canine small clear cell/T-zone lymphoma: clinical presentation and outcome in a retrospective case series. Vet Comp Oncol 2016;14 Suppl 1:117-126. https://doi.org/10.1111/vco.12155
  3. Flood-Knapik KE, Durham AC, Gregor TP, Sanchez MD, Durney ME, Sorenmo KU. Clinical, histopathological and immunohistochemical characterization of canine indolent lymphoma. Vet Comp Oncol 2013;11:272-286. https://doi.org/10.1111/j.1476-5829.2011.00317.x
  4. Seelig DM, Avery P, Webb T, Yoshimoto J, Bromberek J, Ehrhart EJ, Avery AC. Canine T-zone lymphoma: unique immunophenotypic features, outcome, and population characteristics. J Vet Intern Med 2014;28:878-886. https://doi.org/10.1111/jvim.12343
  5. Stein L, Bacmeister C, Kiupel M. Immunophenotypic characterization of canine nodal T-zone lymphoma. Vet Pathol 2021;58:288-292. https://doi.org/10.1177/0300985820974078
  6. Shin SW, Lim Yj, Bae H, Kim J, Cho A, Park J, Lee D, Jung DI, Kim Sk, Yu D. CD3+/CD4+/CD5+/CD8+/CD21+/ CD34-/CD45-/CD79a-/TCRαβ+/TCRγδ-/MHCII+ T-zone lymphoma in a dog with generalized lymphadenopathy: a case report. Korean J Vet Res 2021;61:e21.
  7. Valli VE, Kass PH, San Myint M, Scott F. Canine lymphomas: association of classification type, disease stage, tumor subtype, mitotic rate, and treatment with survival. Vet Pathol 2013;50:738-748. https://doi.org/10.1177/0300985813478210
  8. Owen LN; World Health Organization. TNM Classification of Tumours in Domestic Animals. World Health Organization, Geneva, 1980.
  9. Harris LJ, Rout ED, Hughes KL, Labadie JD, Boostrom B, Yoshimoto JA, Cannon CM, Avery PR, Ehrhart EJ, Avery AC. Clinicopathologic features of lingual canine T-zone lymphoma. Vet Comp Oncol 2018;16:131-139. https://doi.org/10.1111/vco.12322
  10. Parachini-Winter C, Curran KM, Russell DS, Gorman E. A case of canine high-grade T-cell lymphoma immunophenotypically consistent with T-zone lymphoma. Vet Clin Pathol 2018;47:643-648. https://doi.org/10.1111/vcp.12657
  11. Celant E, Marconato L, Stefanello D, Moretti P, Aresu L, Comazzi S, Martini V. Clinical and clinical pathological presentation of 310 dogs affected by lymphoma with aberrant antigen expression identified via flow cytometry. Vet Sci 2022;9:184.
  12. Leach TN, Childress MO, Greene SN, Mohamed AS, Moore GE, Schrempp DR, Lahrman SR, Knapp DW. Prospective trial of metronomic chlorambucil chemotherapy in dogs with naturally occurring cancer. Vet Comp Oncol 2012;10: 102-112. https://doi.org/10.1111/j.1476-5829.2011.00280.x
  13. Withrow SJ, Vail DM. Withrow and MacEwen's Small Animal Clinical Oncology. 6th ed. Elsevier Saunders, Edinburgh, 2020.
  14. Chavalle T, Chamel G, Denoeux P, Lajoinie M, Sayag D, Berny P, Ponce F. Are severe adverse events commonly observed in dogs during cancer chemotherapy? A retrospective study on 155 dogs. Vet Comp Oncol 2022;20:393-403. https://doi.org/10.1111/vco.12782