Applied Chemistry for Engineering (공업화학)

The Korean Society of Industrial and Engineering Chemistry (한국공업화학회)
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Recent Biomedical Applications of Functionalized Polyethylenimine Derivatives

기능성 폴리에틸렌이민 유도체의 생의학적 활용

  • Jaebaek, Jang (Department of Applied Chemistry, College of Engineering, Kyungpook National University) ;
  • Jongho, Jeon (Department of Applied Chemistry, College of Engineering, Kyungpook National University)
  • 장재백 (경북대학교 공과대학 응용화학과) ;
  • 전종호 (경북대학교 공과대학 응용화학과)
  • Received : 2022.12.30
  • Accepted : 2023.01.20
  • Published : 2023.02.10
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Abstract

Polyethylenimine (PEI) is a cationic polymer that can bind to negatively charged biomaterials such as nucleic acids through strong electrostatic interactions. Based on these properties, PEI has been used as an efficient drug delivery system for a long time. However, the strong cationic nature of PEI has the problem of causing cytotoxicity by non-specific interaction with anionic biological materials in the cells. In order to overcome these problems, many researchers have developed various types of biocompatible PEI-based materials. In this review, we would like to introduce the recent developments of functional PEI and their applications in biomedical research.

폴리에틸렌이민(polyethylenimine, PEI)은 양이온성 고분자로서 핵산(nucleic acid)와 같이 음전하를 띄는 생체 물질과 강한 정전기적 상호작용으로 결합할 수 있다. 이러한 특성을 바탕으로 PEI는 효율적인 약물전달체로 오랜 기간 활용되었다. 하지만 PEI의 강한 양이온성은 체내에서 음이온을 띄는 생체 물질과 비특이적으로 상호작용하여 세포독성을 띄는 문제점을 가지고 있다. 그 동안 많은 연구자들은 PEI의 단점을 극복하기 위하여 다양한 종류의 생체 적합 PEI 기반 물질을 개발하였다. 본 리뷰에서는 기능성 PEI의 개발과 이를 활용한 생의학적 연구 동향에 대하여 소개하고자 한다.

Keywords

Acknowledgement

본 연구는 한국연구재단 중견연구(2022R1A2C1003577)의 지원에 의해 수행되었음.

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