Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
권호 표지
DOI QR코드

DOI QR Code

Korean Red Ginseng modulates immune function by upregulating CD4+CD8+ T cells and NK cell activities on porcine

  • Md Jahangir, Alam (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Mohammad Amjad, Hossain (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kiran D., Bhilare (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Chang-Won, Kang (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Jong-Hoon, Kim (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
  • Received : 2022.05.12
  • Accepted : 2022.10.18
  • Published : 2023.01.02
Download PDF
⟨ Previous Next ⟩

Abstract

In the present study, we investigated whether treatment with KRG improve the parameters of immune activity such as the cytotoxicity, populations of CD4+ CD8+T cell, CD3-CD172-CD8+ NK cell and CD172+ monocyte as well as natural cytotoxicity receptors such as Nkp46, Nkp44, Nkp30. In results, KRG significantly increased these immune activities. These results indicate that KRG has distinct immuneenhancing effects by increasing the roles of T cells and NK cell in porcine.

Keywords

Acknowledgement

This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education(2019R1A6A1A03033084). This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(2020R1l1A3072212).

References

  1. Xiaoguang C, Hongyan L, Xiaohong L, Zhaodi F, Yan L, Lihua T, Rui H. Cancer chemopreventive and therapeutic activities of red ginseng. J Ethnopharmacol 1998;60:71-8.  https://doi.org/10.1016/S0378-8741(97)00133-5
  2. Kim JH, Hahm DH, Yang DC, Kim JH, Lee HJ, Shim I. Effect of crude saponin of Korean Red Ginseng on high-fat diet-induced obesity in the rat. J Pharmacol Sci 2005;97:124-31.  https://doi.org/10.1254/jphs.FP0040184
  3. Dawson HA. Comparative assessment of the pig, mouse and human genomes: structural and functional analysis of genes involved in immunity an inflammation. McAnultiy PA,Dawjan Canderup ADWC. In: Hassintgs KL, editor. The minipig in biomedical research. Boca Raton: CRC Press; 2011. p. 664. 
  4. Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A 2001;921:335-9.  https://doi.org/10.1016/S0021-9673(01)00869-X
  5. Kim H, Jang M, Kim Y, Choi J, Jeon J, Kim J, Hwang YI, Kang JS, Lee WJ. Red ginseng and vitamin C increase immune cell activity and decrease lung inflammation induced by influenza A virus/H1N1 infection. J Pharm Pharmacol 2016 Mar;68(3):406-20.  https://doi.org/10.1111/jphp.12529
  6. Wang Y, Yuan L, Cui X, XuW, Fang S, Li Z, Lu M, Wu Y, Ma X, Chi X, et al. Ginseng stem-leaf saponins in combination with selenium promote the immune response in neonatal mice with maternal antibody. Vaccines (Basel) 2020;8(4): 755. Dec 11.  https://doi.org/10.3390/vaccines8040755
  7. Kim S, Lee Y, Cho J. Korean red ginseng extract exhibits neuroprotective effects through inhibition of apoptotic cell death. Biol Pharm Bull. 2014;37(6):938-46.  https://doi.org/10.1248/bpb.b13-00880
  8. Sun Y, Guo M, Feng Y, Zheng H, Lei P, Ma X, Han X, Guan H, Hou D. Effect of ginseng polysaccharides on NK cell cytotoxicity in immunosuppressed mice. Exp Ther Med 2016 Dec;12(6):3773-7.  https://doi.org/10.3892/etm.2016.3840
  9. Tipsmark CK, Jorgensen C, Brande-Lavridsen N, Engelund M, Olesen JH, Madsen SS. Effects of prolactin and cortisol on natural killer (NK) cell surface expression and function of human natural cytotoxicity receptors (NKp46, NKp44 and NKp30). Gen Comp Endocrinol 2009;163(3):270-7. Sep. 15.