Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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The Chronic and Acute Toxicity of Traditional Medicines Containing Terminalia chebula

  • ARONGQIQIGE, ARONGQIQIGE (Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences) ;
  • Gerelmaa, Enebish (Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences) ;
  • Wang, Song (Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Inner Mongolia Minzu University) ;
  • Wei Cheng, Xi (Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Inner Mongolia Minzu University) ;
  • Anuujin, Gantumur (Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences) ;
  • Oyunbaatar, Altanbayar (Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences) ;
  • Hirofumi, Shimomura (Department of Organoid Research, KBBM Ltd.) ;
  • Battogtokh, Chimeddorj (Department of Microbiology and Infection Prevention Control, School of Biomedicine, Mongolian National University of Medical Sciences) ;
  • Batnairamdal, Chuluun (Department of Internal Medicine, International School of Mongolian Medicine, Mongolian National University of Medical Sciences) ;
  • Avarzed, Amgalanbaatar (International Cyber Education Center, Graduate School, Mongolian National University of Medical Sciences)
  • Received : 2022.05.13
  • Accepted : 2022.12.14
  • Published : 2023.03.31
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Abstract

Objectives: Terminalia chebula, the main ingredient of Altan Arur 5, has been used for many years in traditional medicine. This medicine is more effective than other drugs and is used to treat chronic gastritis and gastrointestinal disorders such as peptic ulcers and esophageal reflux. Other ingredients of Altan Arur 5 are Punica granatum (pomegranate), tulip seeds, black balm, and excreta of Trogopterus xanthipes. The main ingredients of T. chebula are antibacterial and analgesic in traditional medicine. Despite having been used for many years and although many studies have been conducted on the beneficial effects of this medicine and its ingredients, the toxicity of Altan Arur 5 has not yet been elucidated. Therefore, we aimed to study the toxicity of Altan Arur 5 to ensure that it is safe to use. Methods: Acute and chronic toxicity of Altan Arur 5 were assessed in 10 Kunming mice and 8 Sprague-Dawley rats, respectively, in different doses. In the acute toxicity study, Altan Arur 5 was orally administered to Kunming mice in doses of 12 g/kg, 24 g/kg, and 48 g/kg for 14 days. In the chronic toxicity study, it was orally administered to Sprague-Dawley rats in doses of 1.25 g/kg, 2.5 g/kg, and 5 g/kg for 12 weeks. Results: No significant differences were observed in the relative organ weights for mice treated with Altan Arur 5 compared with those in the control group. Furthermore, no macro- or microstructural changes were noted in the organs of any group. Conclusion: Our toxicity testing revealed that the traditional medicine Altan Arur 5 has no toxic effects in vivo.

Keywords

Acknowledgement

We are grateful for the collaboration of the Department of Microbiology and Infection Prevention Control, School of Biomedicine, MNUMS and Inner Mongolia Autonomous Region Key Laboratory of Mongolian Medicine Pharmacology for Cardio-Cerebral Vascular System, Inner Mongolia University for Nationalities.

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