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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Mechanosensitive ion channels in apoptosis and ferroptosis: focusing on the role of Piezo1

  • Yong-Jae Kim (Institute of Tissue Regeneration Engineering (ITREN), Dankook University) ;
  • Jeongeun Hyun (Institute of Tissue Regeneration Engineering (ITREN), Dankook University)
  • Received : 2023.01.05
  • Accepted : 2023.01.31
  • Published : 2023.03.31
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Abstract

Mechanosensitive ion channels sense mechanical stimuli applied directly to the cellular membranes or indirectly through their tethered components, provoking cellular mechanoresponses. Among others, Piezo1 mechanosensitive ion channel is a relatively novel Ca2+-permeable channel that is primarily present in non-sensory tissues. Recent studies have demonstrated that Piezo1 plays an important role in Ca2+-dependent cell death, including apoptosis and ferroptosis, in the presence of mechanical stimuli. It has also been proven that cancer cells are sensitive to mechanical stresses due to higher expression levels of Piezo1 compared to normal cells. In this review, we discuss Piezo1-mediated cell death mechanisms and therapeutic strategies to inhibit or induce cell death by modulating the activity of Piezo1 with pharmacological drugs or mechanical perturbations induced by stretch and ultrasound.

Keywords

Acknowledgement

The present research was supported by the research fund of Dankook University in 2020.

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