Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Genomic epidemiology and surveillance of zoonotic viruses using targeted next-generation sequencing

표적화 차세대염기서열분석법을 이용한 인수공통 바이러스의 유전체 역학과 예찰

  • Seonghyeon Lee (Department of Microbiology, College of Medicine, Hallym University) ;
  • Seung-Hwan Baek (Department of Microbiology, College of Medicine, Hallym University) ;
  • Shivani Rajoriya (Department of Microbiology, College of Medicine, Hallym University) ;
  • Sara Puspareni (Department of Microbiology, College of Medicine, Hallym University) ;
  • Won-Keun Kim (Department of Microbiology, College of Medicine, Hallym University)
  • Received : 2022.12.01
  • Accepted : 2022.12.20
  • Published : 2023.03.30
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Abstract

Emerging and re-emerging zoonotic viruses become critical public health, economic, societal, and cultural burdens. The Coronavirus disease-19 (COVID-19) pandemic reveals needs for effective preparedness and responsiveness against the emergence of variants and the next virus outbreak. The targeted next-generation sequencing (NGS) significantly contributes to the acquisition of viral genome sequences directly from clinical specimens. Using this advanced NGS technology, the genomic epidemiology and surveillance play a critical role in identifying of infectious source and origin, tracking of transmission chains and virus evolution, and characterizing the virulence and developing of vaccines during the outbreak. In this review, we highlight the platforms and preparation of targeted NGS for the viral genomics. We also demonstrate the application of this strategy to take advantage of the responsiveness and prevention of emerging zoonotic viruses. This article provides broad and deep insights into the preparedness and responsiveness for the next zoonotic virus outbreak.

Keywords

Acknowledgement

This research was supported by Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Oceans and Fisheries, Korea (20210466).

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