대한의생명과학회지 (Biomedical Science Letters)

  • 제29권1호
  • /
  • Pages.1-10
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  • 2023
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Comparisons of Soluble Klotho Concentration Between Healthy and Patient Cohorts

  • Myeong Kwan Kim (Department of Biotechnology, Hoseo University Graduate School, Hoseo University) ;
  • Dongju Jung (Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University)
  • 투고 : 2023.02.24
  • 심사 : 2023.03.27
  • 발행 : 2023.03.31
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초록

Since its first identification in 1995, klotho (KL) has become the most promising gene to consider for suppressing aging and aging-related diseases. KL knockout mice exhibited similar phenotypes found in human with premature aging such as short lifespan, osteoporosis, arteriosclerosis and hearing loss. Genetically modified mice overexpressing KL prolonged lifespan more than 20%. Also, clinical reports have indicated decreased concentration of the circulating KL protein in blood, which is called soluble klotho (sKL), is closely related to development of senile diseases. The best way to discover significance of sKL on the development of the diseases might be comparison of sKL concentration between controls and patients. Here we analyzed published clinical reports identified sKL concentration in the cohorts. The sKL concentrations were displayed using heatmap for better comparison. In most of the senile diseases, disease progression was inversely related with sKL concentration. Hypertension was the only disease had no relationship, while schizophrenia was the only disease had direct proportion to the disease progression. Overall, sKL concentration in blood could be a marker to determine current severity of the senile diseases and even to estimate disease progression for the patients at the onset of their senile diseases.

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참고문헌

  1. Belloy ME, Napolioni V, Han SS, Le Guen Y, Greicius MD, Initiative Alzheimer's Disease Neuroimaging. 'Association of Klotho-VS Heterozygosity With Risk of Alzheimer Disease in Individuals Who Carry APOE4'. JAMA Neurol. 2020. 77: 849-862. https://doi.org/10.1001/jamaneurol.2020.0414
  2. Chen K, Sun Z. 'Activation of DNA demethylases attenuates aging-associated arterial stiffening and hypertension'. Aging Cell. 2018. 17: e12762.
  3. Cheng YW, Hung CC, Fang WH, Chen WL. 'Association between Soluble alpha-Klotho Protein and Metabolic Syndrome in the Adult Population'. Biomolecules. 2022. 12.
  4. Corcillo A, Fountoulakis N, Sohal A, Farrow F, Ayis S, Karalliedde J. 'Low levels of circulating anti-ageing hormone Klotho predict the onset and progression of diabetic retinopathy'. Diab Vasc Dis Res. 2020. 17: 1479164120970901.
  5. Donate-Correa J, Martin-Nunez E, Mora-Fernandez C, Muros-de-Fuentes M, Perez-Delgado N, Navarro-Gonzalez JF. 'Klotho in cardiovascular disease: Current and future perspectives'. World J Biol Chem. 2015. 6: 351-357. https://doi.org/10.4331/wjbc.v6.i4.351
  6. Drew DA, Katz R, Kritchevsky S, Ix JH, Shlipak MG, Newman AB, Hoofnagle AN, Fried LF, Sarnak M, Gutierrez OM, Semba RD, Neyra JA. 'Soluble Klotho and Incident Hypertension'. Clin J Am Soc Nephrol. 2021. 16: 1502-1511. https://doi.org/10.2215/CJN.05020421
  7. Epstein CJ, Martin GM, Schultz AL, Motulsky AG. 'Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process'. Medicine (Baltimore). 1966. 45: 177-221. https://doi.org/10.1097/00005792-196605000-00001
  8. Espuch-Oliver A, Vazquez-Lorente H, Jurado-Fasoli L, Haro-Munoz T, Diaz-Alberola I, Lopez-Velez MS, Haro-Romero T, Castukki MJ, Amaro-Gahete FJ. 'References values of soluble α-klotho serum levels using an enzyme-linked immunosorbent assay in healthy adults aged 18-85 years'. J Clin Med. 2022. 11: 2415.
  9. Giachelli CM. 'The emerging role of phosphate in vascular calcification'. Kidney Int. 2009. 75: 890-897. https://doi.org/10.1038/ki.2008.644
  10. Gray MD, Shen JC, Kamath-Loeb AS, Blank A, Sopher BL, Martin GM, Oshima J, Loeb LA. 'The Werner syndrome protein is a DNA helicase'. Nat Genet. 1997. 17: 100-103. https://doi.org/10.1038/ng0997-100
  11. Hu MC, Kuro-o M, Moe OW. 'Klotho and chronic kidney disease'. Contrib Nephrol. 2013. 180: 47-63. https://doi.org/10.1159/000346778
  12. Hu MC, Shi M, Zhang J, Quinones H, Griffith C, Kuro-o M, Moe OW. 'Klotho deficiency causes vascular calcification in chronic kidney disease'. J Am Soc Nephrol. 2011. 22: 124-136. https://doi.org/10.1681/ASN.2009121311
  13. Kilicaslan AK, Yildiz S, Emir BS, Kilic F, Atmaca M. 'Serum klotho and FGF23 Levels in Patients with Schizophrenia'. Psychiatry and Clinical Psychopharmacology. 2022. 32: 229-236. https://doi.org/10.5152/pcp.2022.22406
  14. Kim HJ, Lee J, Chae DW, Lee KB, Sung SA, Yoo TH, Han SH, Ahn C, Oh KH. 'Serum klotho is inversely associated with metabolic syndrome in chronic kidney disease: results from the KNOW-CKD study'. Bmc Nephrology. 2019. 20.
  15. Kim HR, Nam BY, Kim DW, Kang MW, Han JH, Lee MJ, Shin DH, Doh FM, Koo HM, Ko KI, Kim CH, Oh HJ, Yoo TH, Kang SW, Han DS, Han SH. 'Circulating alpha-Klotho Levels in CKD and Relationship to Progression'. American Journal of Kidney Diseases. 2013. 61: 899-909. https://doi.org/10.1053/j.ajkd.2013.01.024
  16. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI. 'Mutation of the mouse klotho gene leads to a syndrome resembling ageing'. Nature. 1997. 390: 45-51. https://doi.org/10.1038/36285
  17. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M. 'Suppression of aging in mice by the hormone Klotho'. Science. 2005. 309: 1829-1833. https://doi.org/10.1126/science.1112766
  18. Liang WY, Wang LH, Wei JH, Li QL, Li QY, Liang Q, Hu NQ, Li LH. 'No significant association of serum klotho concentration with blood pressure and pulse wave velocity in a Chinese population'. Sci Rep. 2021. 11: 2374.
  19. Lindberg K, Amin R, Moe OW, Hu MC, Erben RG, Wernerson AO, Lanske B, Olauson H, Larsson TE. 'The Kidney Is the Principal Organ Mediating Klotho Effects'. Journal of the American Society of Nephrology. 2014. 25: 2169-2175. https://doi.org/10.1681/ASN.2013111209
  20. Liu B, Liu J, Shi JS. 'SAMP8 Mice as a Model of Age-Related Cognition Decline with Underlying Mechanisms in Alzheimer's Disease'. J Alzheimers Dis. 2020. 75: 385-395. https://doi.org/10.3233/JAD-200063
  21. Martin-Nunez E, Perez-Castro A, Tagua VG, Hernandez-Carballo C, Ferri C, Perez-Delgado N, Rodriguez-Ramos S, Cerro-Lopez P, Lopez-Castillo A, Delgado-Molinos A, Lopez-Tarruella VC, Arevalo-Gomez MA, Gonzalez-Luis A, Martin-Olivera A, Morales-Estevez CC, Mora-Fernandez C, Donate-Correa J, Navarro-Gonzalez JF. 'Klotho expression in peripheral blood circulating cells is associated with vascular and systemic inflammation in atherosclerotic vascular disease'. Sci Rep. 2022. 12: 8422.
  22. Semba RD, Moghekar AR, Hu J, Sun K, Turner R, Ferrucci L, O'Brien R. 'Klotho in the cerebrospinal fluid of adults with and without Alzheimer's disease'. Neurosci Lett. 2014. 558: 37-40. https://doi.org/10.1016/j.neulet.2013.10.058
  23. Slominski B, Ryba-Stanislawowska M, Skrzypkowska M, Mysliwska J, Mysliwiec M. 'The KL-VS polymorphism of KLOTHO gene is protective against retinopathy incidence in patients with type 1 diabetes'. Biochim Biophys Acta Mol Basis Dis. 2018. 1864: 758-763. https://doi.org/10.1016/j.bbadis.2017.12.015
  24. Tan SJ, Smith ER, Holt SG, Hewitson TD, Toussaint ND. 'Soluble klotho may be a marker of phosphate reabsorption'. Clinical Kidney Journal. 2017. 10: 397-404. https://doi.org/10.1093/ckj/sfw146
  25. Torbus-Paluszczak M, Bartman W, Adamczyk-Sowa M. 'Klotho protein in neurodegenerative disorders'. Neurol Sci. 2018. 39: 1677-1682. https://doi.org/10.1007/s10072-018-3496-x
  26. Xiong JW, Zhan JQ, Luo T, Chen HB, Wan QG, Wang Y, Wei B, Yang YJ. 'Increased Plasma Level of Longevity Protein Klotho as a Potential Indicator of Cognitive Function Preservation in Patients With Schizophrenia'. Frontiers in Neuroscience. 2020. 14.
  27. Yang JH, Hayano M, Griffin PT, Amorim JA, Bonkowski MS, Apostolides JK, Salfati EL, Blanchette M, Munding EM, Bhakta M, Chew YC, Guo W, Yang X, Maybury-Lewis S, Tian X, Ross JM, Coppotelli G, Meer MV, Rogers-Hammond R, Vera DL, Lu YR, Pippin JW, Creswell ML, Dou Z, Xu C, Mitchell SJ, Das A, O'Connell BL, Thakur S, Kane AE, Su Q, Mohri Y, Nishimura EK, Schaevitz L, Garg N, Balta AM, Rego MA, Gregory-Ksander M, Jakobs TC, Zhong L, Wakimoto H, El Andari J, Grimm D, Mostoslavsky R, Wagers AJ, Tsubota K, Bonasera SJ, Palmeira CM, Seidman JG, Seidman CE, Wolf NS, Kreiling JA, Sedivy JM, Murphy GF, Green RE, Garcia BA, Berger SL, Oberdoerffer P, Shankland SJ, Gladyshev VN, Ksander BR, Pfenning AR, Rajman LA, Sinclair DA. 'Loss of epigenetic information as a cause of mammalian aging'. Cell. 2023. 186: 305-326 e27. https://doi.org/10.1016/j.cell.2022.12.027
  28. Zeng CY, Yang TT, Zhou HJ, Zhao Y, Kuang X, Duan W, Du JR. 'Lentiviral vector-mediated overexpression of Klotho in the brain improves Alzheimer's disease-like pathology and cognitive deficits in mice'. Neurobiol Aging. 2019. 78: 18-28. https://doi.org/10.1016/j.neurobiolaging.2019.02.003