대한의생명과학회지 (Biomedical Science Letters)

  • 제29권1호
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  • Pages.26-33
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  • 2023
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
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Ziziphus jujuba mill. Extract Promotes Myogenic Differentiation of C2C12 Skeletal Muscle Cells

  • Gyeong Do Park (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University) ;
  • So Young Eun (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University) ;
  • Yoon-Hee Cheon (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University) ;
  • Chong Hyuk Chung (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University) ;
  • Chang Hoon Lee (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University) ;
  • Myeung Su Lee (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University) ;
  • Ju-Young Kim (Musculoskeletal and Immune Disease Research Institute, School of Medicine, Wonkwang University)
  • 투고 : 2023.03.15
  • 심사 : 2023.03.27
  • 발행 : 2023.03.31
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초록

Ziziphus jujuba Mill. (ZJM), a traditional folk medicine and functional food in South Korea and China, has been reported to having pharmacological activities against anti-cancer, anti-oxidative, and anti-obesity. However, the effect of ZJM related to myoblast differentiation has not been known. In this study, we investigated the effects and mechanism of ZJM on myogenic differentiation of C2C12 cells. ZJM promotes myogenic differentiation and elevates the formation of multinucleated myotube compared to the control group. ZJM significantly increased the mRNA and protein expression of MyHC1, myogenin and MyoD in dose- and time-dependent manner. Interestingly, ZJM significantly inhibited the mRNA and protein expression of protein degradation markers, atrogin-1 and MuRF-1, in dose- and time-dependent manner. Taken together, our data suggest that ZJM is a potential functional candidate for muscle growth and strength by promoting myogenic differentiation.

키워드

과제정보

This study was supported by a grant from the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07049679) (NRF-2022R1C1C2010740).

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