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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Oral administration of ginseng berry concentrate improves lactate metabolism and increases endurance performance in mice

  • Eun-Ju Jin (Department of Precision Medicine, Sungkyunkwan University School of Medicine) ;
  • Shibo Wei (Department of Precision Medicine, Sungkyunkwan University School of Medicine) ;
  • Yunju Jo (Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST)) ;
  • Thanh T. Nguyen (Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST)) ;
  • Moongi Ji (College of Pharmacy, Sunchon National University) ;
  • Man-Jeong Paik (College of Pharmacy, Sunchon National University) ;
  • Jee-Heon Jeong (Department of Precision Medicine, Sungkyunkwan University School of Medicine) ;
  • Se Jin Im (Department of Immunology, Sungkyunkwan University School of Medicine) ;
  • Dongryeol Ryu (Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology (GIST))
  • Received : 2023.03.22
  • Accepted : 2023.04.06
  • Published : 2023.06.30
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Abstract

In the present study, to determine the efficacy of oral supplementation of ginseng berry extracts in augmenting exercise performance and exercise-associated metabolism, male mice were given orally 200 and 400 mg/kg of body weight (BW) of GBC for nine weeks. Although there are no differences in pre-exercise blood lactate levels among (1) the control group that received neither exercise nor GBC, (2) the group that performed only twice-weekly endurance exercise, and (3) and (4) the groups that combined twice-weekly endurance exercise with either 200 or 400 mg/kg GBC, statistically significant reductions in post-exercise blood lactate levels were observed in the groups that combined twice-weekly endurance exercise with oral administration of either 200 or 400 mg/kg GBC. Histological analysis showed no muscle hypertrophy, but transcriptome analysis revealed changes in gene sets related to lactate metabolism and mitochondrial function. GBC intake increased nicotinamide adenine dinucleotide levels in the gastrocnemius, possibly enhancing the mitochondrial electron transport system and lactate metabolism. Further molecular mechanisms are needed to confirm this hypothesis.

Keywords

Acknowledgement

This study was supported by grants from the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT, 2023R1A2C3006220 and 2021R1A5A8029876).

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