Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Successful long-term management of late-stage precursor-targeted immune-mediated anemia with prednisolone and mycophenolate mofetil in a dog

  • Doyun Kim (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Woo-Jin Song (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Sung-Soo Kim (VIP Animal Medical Center) ;
  • Soyoung Jeong (VIP Animal Medical Center) ;
  • Hyun Jeong Hong (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University) ;
  • Youngmin Yun (Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Jeju National University)
  • Received : 2023.01.28
  • Accepted : 2023.06.09
  • Published : 2023.06.30
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Abstract

A 13-year-old neutered male Maltese dog presented to our hospital with lethargy and anorexia. Laboratory abnormalities included severe non-regenerative anemia (hematocrit, 12.9%; reticulocyte count 12.8 K/µL). The cytology of bone marrow revealed erythroid hypercellularity with mild myelofibrosis. Therefore, late-stage precursor-targeted immune-mediated anemia (PIMA) was diagnosed. Multimodal treatment including 2 immunosuppressant drugs (prednisolone and mycophenolate mofetil), antithrombic drug (clopidogrel), and blood transfusion was performed. The dog showed complete remission from PIMA, and the total duration of follow-up was 622 days. This is the first case report of canine PIMA managed successfully with prednisolone and mycophenolate mofetil in Korea.

Keywords

Acknowledgement

This study was funded by the National Research Foundation (NRF) of Korea grant funded by the Korea government (MSIT) (2021R1F1A1063399).

References

  1. Weiss DJ. Bone marrow pathology in dogs and cats with non-regenerative immune-mediated haemolytic anaemia and pure red cell aplasia. J Comp Pathol 2008;138:46-53. https://doi.org/10.1016/j.jcpa.2007.10.001
  2. McManus PM, Craig LE. Correlation between leukocytosis and necropsy findings in dogs with immune-mediated hemolytic anemia: 34 cases (1994-1999). J Am Vet Med Assoc 2001;218:1308-1313. https://doi.org/10.2460/javma.2001.218.1308
  3. Weinkle TK, Center SA, Randolph JF, Warner KL, Barr SC, Erb HN. Evaluation of prognostic factors, survival rates, and treatment protocols for immune-mediated hemolytic anemia in dogs: 151 cases (1993-2002). J Am Vet Med Assoc 2005;226:1869-1880. https://doi.org/10.2460/javma.2005.226.1869
  4. Grimes CN, Fry MM. Nonregenerative anemia: mechanisms of decreased or ineffective erythropoiesis. Vet Pathol 2015;52:298-311. https://doi.org/10.1177/0300985814529315
  5. Assenmacher TD, Jutkowitz LA, Koenigshof AM, de A Lucidi C, Scott MA. Clinical features of precursor-targeted immune-mediated anemia in dogs: 66 cases (2004-2013). J Am Vet Med Assoc 2019;255:366-376. https://doi.org/10.2460/javma.255.3.366
  6. Lucidi CA, de Rezende CL, Jutkowitz LA, Scott MA. Histologic and cytologic bone marrow findings in dogs with suspected precursor-targeted immune-mediated anemia and associated phagocytosis of erythroid precursors. Vet Clin Pathol 2017;46:401-415. https://doi.org/10.1111/vcp.12502
  7. Akiyoshi M, Hisasue M, Neo S, Akiyoshi M. Precursor-targeted immune-mediated anemia in a dog with a stage IV mast cell tumor and bone marrow infiltration. Vet Clin Pathol 2021;50:151-157. https://doi.org/10.1111/vcp.12982