Korean Journal of Plant Resources (한국자원식물학회지)

The Plant Resources Society of Korea (한국자원식물학회)
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Protective Effect of Glycyrrhiza New Domestic Variety on the Acute Pancreatitis

국내 감초 신품종의 급성 췌장염 보호 효과

  • Dong-Gu Kim (Department of Oriental Medicine Resources, Jeonbuk National University) ;
  • Kyung Hyun Min (School of Pharmacy and Institute of New Drug Development, Jeonbuk National University)
  • 김동구 (전북대학교 환경생명자원대학 한약자원학과) ;
  • 민경현 (전북대학교 약학대학 약학과)
  • Received : 2023.04.24
  • Accepted : 2023.04.28
  • Published : 2023.08.01
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Abstract

Glycyrrhiza korshinskyi Grig. (Gk), which is a new variety of Glycyrrhiza, was developed by the National Institute of Horticultural and Herbal Science in Korea Rural Development Administration. It is improved the limitations of traditional Glycrrhiza species such as G. uralensis Fisch., G. glabra L., and G. inflata Batal. and has been reported various pharmacological effects. The aim of this study is to investigate the protective effect of Gk on the acute pancreatitis, because which has not been revealed yet. AP was induced via intraperitoneal injection of cerulein (50 ㎍/kg) hourly for 7 times in C57BL/6 mice. Gk water extract (20 or 50 mg/kg) or saline was administrated via oral gavage 1 h before the first injection of cerulein. The mice were sacrificed at 5 h after the final injection of cerulein. The inflammatory cell infiltration in pancreatic tissue was decreased by the administration of Gk water extract compared to the AP group. Also, serum amylase and lipase levels were decreased by the administration of Gk water extract compared to the AP group. These results suggest that Gk have protective effect on the acute pancreatitis.

본 연구를 통해 국내 감초 신품종인 G. korshinskyi Grig.가 cerulein으로 유도한 생쥐의 급성 췌장염시 증가하는 염증성 세포의 유입과 혈청 소화효소(Amylase, Lipase) 수치를 유의하게 억제함으로써 급성 췌장염에 대한 보호 효과를 나타낸다는 것을 알 수 있었다. 이를 통해 급성 췌장염을 예방할 수 있는 의약품 소재로써 국내 감초 신품종의 가능성을 제기한다는 데 의의가 있지만, 치료 효과로써의 효능 및 억제 기전에 대한 보완연구가 뒷받침되어야 할 필요가 있다고 판단된다.

Keywords

Acknowledgement

본 논문은 농촌진흥청 연구사업(세부과제번호: PJ014246)의 지원을 받아 수행되었다.

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