Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Jakyakkamchobuja-tang on Rheumatoid Arthritis in Rat Model: Systemic Review and Meta-Analysis

류마티스 관절염 백서 모델에서 작약감초부자탕의 효과: 체계적 문헌고찰 및 메타분석

  • Che-Yeon Kim (School of Korean Medicine, Pusan National University) ;
  • Sang-Hyun Lee (Department of Korean Medicine, Graduate School, Pusan National University) ;
  • Man-Suk Hwang (School of Korean Medicine, Pusan National University)
  • 김채연 (부산대학교 한의학전문대학원) ;
  • 이상현 (부산대학교 대학원 한의학과) ;
  • 황만석 (부산대학교 한의학전문대학원)
  • Received : 2023.07.05
  • Accepted : 2023.07.11
  • Published : 2023.07.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives This study was designed to review the effect of Jakyakkamchobuja-tang on rat model with rheumatoid arthritis. Methods We used seven databases (PubMed, EMBASE, Cochrane CENTRAL, China National Knowledge Infrastructure, Oriental Medicine Advanced Searching Integrated System, Korean studies Information Service System, National Digital Science Library) from their inception to May 2023 without language restrictions. Systematic Review Centre for Laboratory Animal Experimentation's tool was used to evaluate the risk of bias. RevMan software (V5.4) was used for the meta-analysis. Results Five studies were selected following our inclusion criteria. The arthritis index decreased significantly (standardized mean difference=-2.06; 95% confidence interval=-3.07 to -1.04; p<0.0001) in Jakyakkamchobuja-tang group. Also, serum cytokines in serum and paw swelling degree decreased in Jakyakkamchobuja-tang group. Conclusions Jakyakkamchobuja-tang may be effective in treating rheumatoid arthritis. Although there is a limitation that the design of drug dosage varies between papers, it can be expected to be applied as an alternative to Western medicine, and it is believed to contribute to the standardization of herbal treatment for rheumatoid arthritis.

Keywords

Acknowledgement

This work was supported by a 2-Year Research Grant of Pusan National University.

References

  1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature. 2003;423(6937):356-61. https://doi.org/10.1038/nature01661
  2. Cai Y, Zhang J, Liang J, Xiao M, Zhang G, Jing Z, Lv L, Nan K, Dang X. The burden of rheumatoid arthritis: findings from the 2019 Global Burden of Diseases study and forecasts for 2030 by Bayesian age-period-cohort analysis. Journal of Clinical Medicine. 2023;12(4):1291.
  3. Aletaha D, Josef S. Diagnosis and management of rheumatoid arthritis: a review. JAMA. 2018;320(13):1360-72. https://doi.org/10.1001/jama.2018.13103
  4. Colebatch AN, Marks JL, Edwards CJ. Safety of nonsteroidal anti-inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving methotrexate for inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis). Cochrane Database of Systematic Reviews. 2011;9(11):CD008872.
  5. Zhang JY. Effects of Shaoyao Gancao Fuzi Decoction on rheumatoid arthritis and influence of serum VEGF expression. Forum On Traditional Chinese Medicine. 2017;32(2):32-4.
  6. Zhang W. Effect of Shaofan FuZi Decoction on inflammatory response and joint activity of rheumatoid arthritis patients with cold-dampness obstruction. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine. 2021;21(12):24-6.
  7. Zheng W, Zhu Y, Ma J, Zhuge Y, Liu X, Zhang J, Hou X. Clinical observation on jiawei shaogan Fuzi decoction combined with western medicine in the treatment of 30 rheumatoid arthritis patients with cold-damp obstruction syndrome at active phase. Journal of Traditional Chinese Medicine. 2018;59(9):760-4.
  8. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collage an experimental model of arthritis. Journal of Experimental Medicine. 1997;146(3):857-68. https://doi.org/10.1084/jem.146.3.857
  9. Pearson CM. Development of arthritis, periarthritis and periostatis in rat given adjuvants. Proceedings of the Society for Experimental Biology and Medicine. 1956;91(1):95-101. https://doi.org/10.3181/00379727-91-22179
  10. Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies. BMC Medical Research Methodology. 2014;14:43
  11. Wang ZE, Yang JF, Yang Y, Zhang TC. Effect of Jiawei Shaogan Fuzi Decoction on blood rheology of rats with adjuvant arthritis. Journal of Shanxi College of Traditional Chinese Medicine. 2007;8(6):14-5.
  12. Yuan F, Zhu YL. Mechanism study of modified Shaogan Fuzi Decoction on the angiogenesis inhibitor factors in the synovial of rats with collagen-induced arthritis. Beijing Journal of Traditional Chinese Medicine. 2014;33(7):551-4.
  13. Jing WX, Hou XJ, Sun WY, Yao ZQ, Zhu YL. Adding Shaogan Fuzi Tang to influence of relative gene expression of the JAK/STAT signaling pathway of the joint synovial tissue in CIA rat. Acta Chinese Medicine. 2016;31(4):545-9.
  14. Liu Y, Zhu YL, Hou XJ, Zhu YL. Effects of modified Shaogan Fuzi Decoction on angiogenesis relating factors in the synovial tissue of CIA rats. Global Traditional Chinese Medicine. 2015;8(6):692-6.
  15. Yuan F, Hou XJ, Liu XP, Liu Y, Zhu YL. Influence of modified Shaogan Fuzi Decoction on expressions of OPG-RANKL of rats with typeII collagen-induced arthritis. China Journal of Traditional Chinese Medicine and Pharmacy. 2015;30(5):1661-5.
  16. Liu XP, Ma JF, Zheng W, Hou XJ, Zhu YL. Effects of Shaogan Fuzi Decoction on expression of Egr2/Egr3 and the signal pathway in collagen-induced arthritis rats with syndrome of cold. China Journal of Traditional Chinese Medicine and Pharmacy. 2018;33(7):2811-6.
  17. Liu XP, Ma JF, Zheng W, Hou XJ. IFN-γ and IL-17A in rats with CIA cold syndrome treated by modified Shaogan Fuzi decoction Effect of expression. Global Traditional Chinese Medicine. 2018;11(2):167-71.
  18. Dong LL, Shi L, Miao F, Feng CR, Jing WX, Jia ZH, Zhao YY, Sun WY. Mechanism of Shaogan Fuzi decoction for rheumatoid arthritis based on TMT quantitative proteomics technology. Central South Pharmacy. 2021;19(3):402-12.
  19. Zhang YT, Hou XJ, Liu XP, Zhy YL. Effect of modified Shaogan Fuzi Decoction on the pathology of joint synovium and expression level of serum IL-2, IL-17A and TNF-α in rats with collagen induced arthritis). Journal of Tianjin University of Traditional Chinese Medicine. 2021;40(1):93-7.
  20. Dong LL, Feng CR, Zhao YY, Shi L, Wu SY, Jiang WX, Jia ZH, Sun WY. Effect and mechanism of Shaogan Fuzi decoction on rats with collagen induced arthritis based on PPAR-γ/NF-κB signaling pathway. Central South Pharmacy. 2022;20(1):45-51.
  21. Kang TL, Xi YJ, Qian TL, Zhu YL, Hou XJ. Jiawei Shaogan Fuzi Decoction regulates PI3K /Akt signaling pathway to reduce rheumatoid arthritis related research on the progress of interstitial lung disease. Global Traditional Chinese Medicine. 2022;15(11):2071-7.
  22. Shi L, Zhao YY, Feng CR, Miao F, Dong LL, Wang TQ, Stalin A, Zhang JY, Tu JR, Liu KX, Sun WY, Wu JR. Therapeutic effects of shaogan fuzi decoction in rheumatoid arthritis: network pharmacology and experimental validation. Frontiers in Pharmacology. 2022;13:967164.
  23. Qian TL, Zhang YT, Hou XJ, Liu XP, Zheng W, Kang TL, Wang HY. Effect of modified Shaogan Fuzi decoction on the inflammation in old rats with collagen-induced by early growth reactive protein 2 regulation. Global Traditional Chinese Medicine. 2022;15(3):370-7.
  24. Xi YJ, Kang TL, Qian TL, Hou XJ, Zhu YL. Effect of modified Shaogan Fuzi Decoction on the pathology of lung interstitium and expression levels of serum KL-6, IL-6 and IL-17 in CIA rats. Jilin Journal of Chinese Medicine. 2022;42(6):703-7.
  25. Zhao YY, Dong LL, Feng CR, Shi L, Maio F, Wu SY, Jing WX, Jia ZH, Sun WY, Lyu P. Mechanism of Shaogan Fuzi decoction for rheumatoid arthritis based on serum metabonomics. Central South Pharmacy. 2022;20(9):2059-67.
  26. Peter S, Stefan S, Rolf M, Peter P. Synthesis and Degradation of Hyaluronate by Synovia from patients with rheumatoid arthritis. The Journal of Rheumatology. 1995;22(3):400-5.
  27. Kwon YJ, Shung SJ, Kim TY, Par k MC. Per oxisome proliferator-activated receptor-γ agonist inhibits pro-inflammatory gene expressions and cellular proliferation of fibroblast like synoviocytes from patients with rheumatoid arthritis by down-regulation of NF-kappaB. The Journal of the Korean Rheumatism Association. 2010;17(2):153-61. https://doi.org/10.4078/jkra.2010.17.2.153
  28. Joosten LA, Helsen MM, van de Loo FA van de Berg WB. Anticytokine treatment of established type II collagen-induced arthritis in DBA/a mice: a comparative study using anti-TNF alpha, anti-IL-1 alpha/beta, and IL-1Ra. Arthritis & Rheumatology. 1996;39(5):797-809. https://doi.org/10.1002/art.1780390513
  29. Song CY, Xu YG, Lu YQ. Use of Tripterygium wilfordii Hook F for immune-mediated inflammatory diseases: progress and future prospects. Journal of Zhejiang University-SCIENCE B. 2020;21(4):280-90. https://doi.org/10.1631/jzus.B1900607
  30. Ru Y, Luo Y, Zhou Y, Kuai L, Sun X, Xing M, Liu L, Lu Y, Hong S, Chen X, Song J, Luo Y, Fei X, Li B, Li X. Adverse events associated with treatment of Tripterygium wilfordii Hook F: a quantitative evidence synthesis. Frontiers in Pharmacology. 2019;10:1250.
  31. Obiri DD, Osafo N, Ayande PG, Antwi AO. Xylopia aethiopica (Annonaceae) fruit extract suppresses Freund's adjuvant-induced arthritis in Sprague-Dawley rats. Journal of Ethnopharmacology. 2014;152(3):522-31. https://doi.org/10.1016/j.jep.2014.01.035
  32. Park BH. Commentary on clinical application of SangHan-Ron. 1st ed. Euibang. 2004:220-2.
  33. Brand DD, Latham KA, Rosloniec E. Collagen-induced arthritis. Nature Protocols. 2007;2(5):1269-75. https://doi.org/10.1038/nprot.2007.173
  34. Mateen S, Zafar A, Moin S, Khan AQ, Zubair S. Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clinica Chimica Acta. 2016;455:161-71. https://doi.org/10.1016/j.cca.2016.02.010