대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
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만성 위염에 대한 이중탕(理中湯)의 효과 : 체계적 문헌 고찰 및 메타 분석

The Effect of Yijung-tang for Chronic Gastritis: A Systemic Review and Meta-Analysis

  • 김예슬 (동의대학교 부속 한방병원 한방내과) ;
  • 이영서 (동의대학교 부속 한방병원 한방내과) ;
  • 김경민 (동의대학교 부속 한방병원 한방내과) ;
  • 진명호 (동의대학교 부속 한방병원 한방내과)
  • Ye-seul Kim (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Yeong-seo Lee (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Kyoung-min Kim (Dept. of Korean Internal Medicine, Dong-Eui University) ;
  • Myung-ho Jin (Dept. of Korean Internal Medicine, Dong-Eui University)
  • 투고 : 2023.08.31
  • 심사 : 2023.10.10
  • 발행 : 2023.09.30
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초록

Objective: This study assessed the effectiveness of using Yijung-tang to treat chronic gastritis through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: The search was conducted using keywords such as "gastritis", "Lizhong", "Yijung", and "Chronic gastritis" on July 31, 2023. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), Traditional chinese medicine symptom score (TSS), gastric hormones, and symptom relief time, using the Review Manager website. Results: A total of 11 RCT studies were selected. The treatment group (Yijung-tang-gagam or Yijung-tang-gagam+Western medicine) showed significant improvement effects in terms of TER, TSS, serum gastrointestinal hormones (motilin (MTL), gastrin (GAS), and somatostatin (SS)), and symptom relief time compared to the control group (Western medicine). TER-RR : 1.20, 95% CI : 1.11 to 1.30, P≤0.00001, RR : 1.21, 95% CI : 1.14 to 1.28, P≤0.00001; MTL-MD : 35.99, 95% CI : 30.79 to 41.20, P≤0.00001); GAS-MD : 103.33, 95% CI : 97.62 to 109.04, P≤0.00001); SS : MD : -37.19, 95% CI : -41.75 to -32.64, P≤0.00001; symptom relief time (nausea)-MD : -1.96, 95% CI : -2.47 to -1.45, P≤0.00001; symptom relief time (colic)-MD : -1.75, 95% CI : -2.31 to -1.18, P≤0.00001. Conclusion: This study suggests that Yijung-tang is effective against chronic gastritis. However, the number of studies was insufficient, and the diagnosis and evaluation criteria were not standardized. Furthermore, because of the low quality of the included studies, more clinical studies need to be conducted to increase the possibility of clinical use.

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참고문헌

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