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Inclusion body myositis accompanied with T-cell large granular lymphocyte leukemia

  • Dong-Young Jeong (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Seung-Hee Lee (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jungmin So (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ji Yon Kim (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Young Chul, Kim (Department of Plastic and Reconstructive Surgery, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Miyoung Kim (Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Eun-Ji Choi (Department of Hematology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Eun-Jae Lee (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hyung Jun Park (Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Young-Min Lim (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Hyunjin Kim (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2023.08.02
  • Accepted : 2023.10.11
  • Published : 2023.10.30

Abstract

Inclusion body myositis (IBM) is a late-onset myopathy that manifests as distinct muscle weakness in the quadriceps, finger flexors, and ankle dorsiflexors. T-cell large granular lymphocyte (T-LGL) leukemia is a late-onset clonal disorder of CD8+ cytotoxic T-cells that is often accompanied by autoimmune diseases. To date, the association between IBM and T-LGL leukemia has been infrequently reported. Here, we report a case of a patient with T-LGL leukemia who developed IBM, along with in-depth laboratory, electrophysiological, and pathologic findings.

Keywords

Acknowledgement

This study was supported by grants from Asan Institute for Life Science, Asan Medical Center, Seoul, South Korea (2023IP0107).

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