The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
권호 표지
DOI QR코드

DOI QR Code

Prediction the efficacy and mechanism of action of Daehwangmokdanpitang to treat psoriasis based on network pharmacology

네트워크 약리학 기반 대황목단피탕(大黃牧丹皮湯)의 건선 조절 효능 및 작용 기전 예측

  • Bitna Kweon (Department of Pharmacology, College of Korean Medicine, Wonkwang University) ;
  • Dong-Uk Kim (Department of Pharmacology, College of Korean Medicine, Wonkwang University) ;
  • Gabsik Yang (Department of Pharmacology, College of Korean Medicine, Woosuk University) ;
  • Il-Joo Jo (Central Stroke Center of Korean medicine, College of Korean Medicine, Wonkwang University)
  • 권빛나 (원광대학교 한의과대학 약리학교실) ;
  • 김동욱 (원광대학교 한의과대학 약리학교실) ;
  • 양갑식 (우석대학교 한의과대학 임상약리연구실) ;
  • 조일주 (원광대학교 한의과대학 뇌졸중한의중점연구센터)
  • Received : 2023.10.10
  • Accepted : 2023.11.25
  • Published : 2023.11.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : This study used a network pharmacology approach to elucidate the efficacy and molecular mechanisms of Daehwangmokdanpitang (DHMDPT) on Psoriasis. Methods : Using OASIS databases and PubChem database, compounds of DHMDPT and their target genes were collected. The putative target genes of DHMDPT and known target genes of psoriasis were compared and found the correlation. Then, the network was constructed using Cytoscape 3.10.1. The key target genes were screened by Analyzer network and their functional enrichment analysis was conducted based on the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) Pathways to predict the mechanisms. Results : The result showed that total 30 compounds and 439 related genes were gathered from DHMDPT. 264 genes were interacted with psoriasis gene set, suggesting that the effects of DHMDPT are closely related to psoriasis. Based on GO enrichment analysis and KEGG pathways, 'Binding', 'Cytokine Activity', 'Receptor Ligand Activity' 'HIF-1 signaling pathway', 'IL-17 signaling pathway', 'Toll-like receptor signaling pathway', and 'TNF signaling pathway' were predicted as functional pathways of 16 key target genes of DHMDPT on psoriasis. Among the target genes, IL6, IL1B, TNF, AKT1 showed high correlation with the results of KEGG pathways. Additionally, Emodin, Acetovanillone, Gallic acid, and Ferulic acid showed a high relevance with key genes and their mechanisms. Conclusion : Through a network pharmacological method, DHMDPT was predicted to have high relevance with psoriasis. This study could be used as a basis for studying therapeutic effects of DHMDPT on psoriasis.

Keywords

Acknowledgement

본 연구는 과학기술정보통신부의 재원으로 한국연구재단의 이공학학술연구기반구축(R&D) 지역대학 우수과학자 지원사업(RS-2023-00248541)과 보건복지부의 재원으로 한국보건산업진흥원의 보건의료 기술연구개발사업 지원(HF22C0072)에 의하여 이루어짐.

References

  1. Lee A, Chun J. Prediction of efficacy of the compounds and atherosclerosis target gene in Yijin-tang based on network pharmacology. Korean Herbal Medicine Informatics. 2017;5(3):31-42. DOI:10.22674/KHMI5-3-4. 
  2. Lee AY, Lee J, Chun JM. Prediction of potential targets efficacy derived from ginger active ingredients using network pharmacology. Korean Herbal Medicine Informatics. 2020;8(2):255-66. DOI:10.22674/KHMI8-2-11. 
  3. Zhang R, Zhu X, Bai H, Ning K. Network pharmacology databases for traditional Chinese medicine: review and assessment. Frontiers in pharmacology. 2019;10:123. DOI:10.3389/fphar.2019.00123. 
  4. Hopkins AL. Network pharmacology. Nature Biotechnology. 2007;25(10):1110-1. DOI:10.1038/nbt1007-1110. 
  5. Lee WY, Lee CY, Kim YS, Kim CE. The Methodological Trends of Traditional Herbal Medicine Employing Network Pharmacology. Biomolecules. 2019;9(8):362. DOI:10.3390/biom9080362. 
  6. Kweon BN, Ryu SM, Kim DU, Oh JY, Jang MK, Park SJ, Bae GS. Network pharmacology-based prediction of efficacy and mechanism of Chongmyunggongjindan acting on Alzheimer's disease. Journal of Korean Medicine. 2023;44(2):106-18.  https://doi.org/10.13048/jkm.23019
  7. Han CY, Kim JD, Seo GY, Kim KS, Kim YB. Investigation of Effective Korean Herbal Medicine for Psoriasis. The Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2021;34(3):70-9. 
  8. Kim JY, Choi MR, Choi CW, Park KD, Lee Y, Kim CD, Seo YJ, Lee JH. Immunohistochemical Study of Psoriasis-related Gene Expression in Imiquimod-induced Psoriasis-like Mouse Model. Korean Journal of Dermatology. 2018:609-13. 
  9. Guttman-Yassky E, Nograles KE, Krueger JG. Contrasting pathogenesis of atopic dermatitis and psoriasis-part I: clinical and pathologic concepts. The Journal of allergy and clinical immunology. 2011;127(5):1110-8. DOI:10.1016/j.jaci.2011.01.053. 
  10. Kamiya K, Kishimoto M, Sugai J, Komine M, Ohtsuki M. Risk factors for the development of psoriasis. International journal of molecular sciences. 2019;20(18):4347. DOI:10.3390/ijms20184347. 
  11. Christophers E. Psoriasis--epidemiology and clinical spectrum. Clinical and experimental dermatology. 2001;26(4):314-20. DOI:10.1046/j.1365-2230.2001.00832.x. 
  12. Lee JY, Kang SC, Park JS, Jo SJ. Prevalence of psoriasis in Korea: a population-based epidemiological study using the Korean National Health Insurance Database. Annals of dermatology. 2017;29(6):761-7. DOI:10.5021/ad.2017.29.6.761. 
  13. Kang DW, Han CY, Kim JD, Kim KS, Kim YB. A Proposal and Considerations for Treatment Approaches of Psoriasis. The Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2020;33(3):99-114. DOI:10.6114/jkood.2020.33.3.099. 
  14. Jung KJ, Kim TG, Lee JW, Lee M, Oh J, Lee SE, Chang HJ, Jee SH, Lee MG. Increased risk of atherosclerotic cardiovascular disease among patients with psoriasis in Korea: A 15-year nationwide population-based cohort study. The Journal of dermatology. 2019;46(10):859-66. DOI:10.1111/1346-8138.15052. 
  15. Greb JE, Goldminz AM, Elder JT, Lebwohl MG, Gladman DD, Wu JJ, Mehta NN, Finlay AY, Gottlieb AB. Psoriasis. Nature reviews. Disease primers. 2016;24(2):16082. DOI:10.1038/nrdp.2016.82. 
  16. Kim NK, Hwang C, Lim GS. The oriental and occidental bibliographic study of psoriasis. The Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 1999;12(1):154-78. 
  17. Cho EC, Kim KS. A Review on Patterns and Classification Criteria of Psoriasis by analyzing Chinese Theses. The Journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2020;33(2):112-29. DOI:10.6114/jkood.2020.33.2.112. 
  18. Kim BH, Kim KI, Kang SH, Park JG, Kang DW, Nam HJ, Kim YB, Lee JH, Kim KS. Explanation and Elaboration of the Clinical Trial Guidelines for Psoriasis Using Herbal Medicine. The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology. 2018;31(2):40-59. DOI:10.6114/jkood.2018.31.2.040. 
  19. Kim SM, Sun JJ, Choi CM, Jung JH, Hwang JW, Min IK, Kim CH, Jung WS, Moon SK, Cho KH, Kim YS, Bae HS. The Relationship among Bloodstasis, CAVI and Cardiovascular Risk in Stroke Patients. The Journal of Internal Korean Medicine. 2007;28(3):421-33. 
  20. Reich K. The concept of psoriasis as a systemic inflammation: implications for disease management. Journal of the European Academy of Dermatology and Venereology. 2012;26:3-11. DOI:10.1111/j.1468-3083.2011.04410.x. 
  21. Medicine C-ebapoFatCoO. Formular Study. Seoul: Younglim; 1999. 609-10 p. 
  22. Park SJ, Jeong JG, Seo SW, Hwang SW, Kim YW, Song DS, Chae YS, Shin MK, Song HJ. Effects of Gami-Daehwangmokdanpi-Tang against CCK-induced acute pancreatitis. The Korea Journal of Herbology. 2005;20(3):59-65. 
  23. Keisetsu O. Characteristics of Oriental Medicine. Seoul: ChonpaScience; 2017. 192 p. 
  24. Nguyen LTH, Ahn SH, Shin HM, Yang IJ. Anti-Psoriatic Effect of Rheum palmatum L. and Its Underlying Molecular Mechanisms. International Journal of Molecular Sciences. 2022;23(24). DOI:10.3390/ijms232416000. 
  25. Lee MH, Hong SH, Park C, Han MH, Kim SO, Hong SH, Kim GY, Choi YH. Anti-inflammatory effects of Daehwangmokdantang, a traditional herbal formulation, in lipopolysaccharide-stimulated RAW 264.7 macrophages. Experimental and Therapeutic Medicine. 2017;14(6):5809-16. DOI:10.3892/etm.2017.5296. 
  26. Jeon DJ, Cha YY, Lee E. Inflammatory Effect of Rheum undulatum L. Journal of Korean Medicine Rehabilitation. 2011;21(1):35-46. 
  27. Kim HY, Seol IC, Yoo HR, Kim YS. The Effect of Trichosanthes Kirilowii Maximowicz Extract and Trichosanthes Kirilowii Maximowicz Cheonghyeol Plus on Anti-Inflammatory Factor Expression in Human Umbilical Vein Endothelial Cells (HUVECs). The Journal of Internal Korean Medicine. 2022;43(4):514-28. DOI:10.22246/jikm.2022.43.4.514. 
  28. Park JH, Kim KJ. The Effect of Moutan Cortex on Pro-inflammatory Cytokines through NF-κB & MAPKs pathway in HMC-l. The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology. 2009;22(2):1-18. 
  29. Joe WA, Jang MJ, Cheon SJ, Sung JY, Choi EY, Kang BY, Jung SH, Jung YS, Kim YS, An BJ, Lee CA, Lee JT. Cosmeceutical activities and Anti-inflammatory effects of Shell from Persicae semen. The Korea Journal of Herbology. 2006;21(2):87-93. 
  30. Oh KK, Adnan MD, Cho DH. A network pharmacology analysis on drug-like compounds from Ganoderma lucidum for alleviation of atherosclerosis. Journal of Food Biochemistry. 2021;45(9):e13906. DOI:10.1111/jfbc.13906. 
  31. Zhang L, Shi X, Huang Z, Mao J, Mei W, Ding L, Zhang L, Xing R, Wang P. Network pharmacology approach to uncover the mechanism governing the effect of radix achyranthis bidentatae on osteoarthritis. BMC complementary medicine and therapies. 2020;20(1):121. DOI:10.1186/s12906-020-02909-4. 
  32. Wen Y, Zhan Y, Tang S, Kang J, Wu R, Tang X. Mechanistic prediction of Chinese herb compound (Zhi Zhu Ma Ren Pill) in the treatment of constipation using network pharmacology and molecular docking. Natural Product Communications. 2022;17(9). DOI:10.1177/1934578X221124780. 
  33. Lipinski CA. Lead- and drug-like compounds: the rule-of-five revolution. Drug Discovery Today Technologies. 2004;1(4):337-41. DOI:10.1016/j.ddtec.2004.11.007. 
  34. Matsson P, Kihlberg J. How big is too big for cell permeability? : ACS Publications; 2017 : 1662-4. DOI:10.1021/acs.jmedchem.7b00237. 
  35. Muhr P, Zeitvogel J, Heitland I, Werfel T, Wittmann M. Expression of interleukin (IL)-1 family members upon stimulation with IL-17 differs in keratinocytes derived from patients with psoriasis and healthy donors. The British Journal of Dermatology. 2011;165(1):189-93. DOI:10.1111/j.1365-2133.2011.10302.x. 
  36. Gran F, Kerstan A, Serfling E, Goebeler M, Muhammad K. Focus: Skin: Current Developments in the Immunology of Psoriasis. The Yale journal of biology and medicine. 2020;93(1):97. 
  37. Tian S, Krueger JG, Li K, Jabbari A, Brodmerkel C, Lowes MA, Suarez-Farinas M. Meta-analysis derived (MAD) transcriptome of psoriasis defines the "core" pathogenesis of disease. Plos One. 2012;7(9):e44274. DOI:10.1371/journal.pone.0044274. 
  38. Suarez-Farinas M, Li K, Fuentes-Duculan J, Hayden K, Brodmerkel C, Krueger JG. Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis. Journal of Investigative Dermatology. 2012;132(11):2552-64. DOI:10.1038/jid.2012.184. 
  39. Song HJ, Park CJ, Kim TY, Choe YB, Lee SJ, Kim NI, Cho JW, Jeon JH, Jang MS, Youn JI, Kim MH, Park JS, Kim KH, Kim BS, Youn SW, Lee JH, Lee MG, Ahn SK, Won YH, Yun SK, Shin BS, Seo SJ, Lee JY, Kim KJ, Ro YS, Kim YD, Yu DY, Choi JH. The Clinical Profile of Patients with Psoriasis in Korea: A Nationwide Cross-Sectional Study (EPIPSODE). Annals of dermatology. 2017;29(4):462-70. DOI:10.5021/ad.2017.29.4.462. 
  40. Kang DW, Han CY, Kim JD, Kim KS, Kim YB. A Proposal and Considerations for Treatment Approaches of Psoriasis. The Journal of Korean Medicine Ophthalmology & Otolaryngology & Dermatology. 2020;33(3):99-114. DOI:10.6114/jkood.2020.33.3.099. 
  41. Jo IJ. Inhibitory activity of Terminalia chebula extract against TNF-α/IFN-γ-induced chemokine increase on human keratinocyte, HaCaT cells. The Korea Journal of Herbology. 2022;37(3):41-7. 
  42. Guo S, Zhou JY, Tan C, Shi L, Shi Y, Shi J. Network Pharmacology-Based Analysis on the Mechanism of Action of Ephedrae Herba-Cinnamomi Ramulus Couplet Medicines in the Treatment for Psoriasis. Medical Science Monitor. 2021;27:e927421. DOI:10.12659/MSM.927421. 
  43. Yue C, Feng J, Gao A. A network pharmacology and molecular docking investigation on the mechanisms of Shanyaotianhua decoction (STT) as a therapy for psoriasis. Medicine. 2023;102(34):e34859. DOI:10.1097/MD.0000000000034859. 
  44. Ioannou M, Sourli F, Mylonis I, Barbanis S, Papamichali R, Kouvaras E, Zafiriou E, Siomou P, Klimi E, Simos G, Roussaki-Schulze AV, Koukoulis G. Increased HIF-1 alpha immunostaining in psoriasis compared to psoriasiform dermatitides. Journal of cutaneous pathology. 2009;36(12):1255-61. DOI:10.1111/j.1600-0560.2009.01264.x. 
  45. Blauvelt A. IL-6 Differs from TNF-alpha: Unpredicted Clinical Effects Caused by IL-6 Blockade in Psoriasis. The Journal of Investigative Dermatology. 2017;137(3):541-2. DOI:10.1016/j.jid.2016.11.022. 
  46. Vasilopoulos Y, Sourli F, Zafiriou E, Klimi E, Ioannou M, Mamuris Z Simos G, Koukoulis G, RoussakiSchulze A. High serum levels of HIF-1alpha in psoriatic patients correlate with an over-expression of IL-6. Cytokine. 2013;62(1):38-9. DOI:10.1016/j.cyto.2013.02.029. 
  47. Tang YY, Wang DC, Wang YQ, Huang AF, Xu WD. Emerging role of hypoxia-inducible factor-1α in inflammatory autoimmune diseases: A comprehensive review. Frontiers in Immunology. 2023;13:1073971. DOI:10.3389/fimmu.2022.1073971. 
  48. Mosca M, Hong J, Hadeler E, Hakimi M, Liao W, Bhutani T. The role of IL-17 cytokines in psoriasis. ImmunoTargets and therapy. 2021:409-18. DOI:10.2147/ITT.S240891. 
  49. Furue M, Furue K, Tsuji G, Nakahara T. Interleukin-17A and Keratinocytes in PsoriasisInternational Journal of Molecular Sciences. 2020;21(4). DOI:10.3390/ijms21041275. 
  50. Cai Y, Xue F, Quan C, Qu M, Liu N, Zhang Y, Fleming C, Hu X, Zhang HG, Weichselbaum R, Fu YX, Tieri D, Rouchka EC, Zheng J, Yan J. A Critical Role of the IL-1beta-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis. The Journal of Investigative dermatology. 2019;139(1):146-56. DOI:10.1016/j.jid.2018.07.025. 
  51. Lai CY, Su YW, Lin KI, Hsu LC, Chuang TH. Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation. Journal of Immunology Research. 2017;2017:7807313. DOI:10.1155/2017/7807313. 
  52. Mylonas A, Conrad C. Psoriasis: Classical vs. Paradoxical. The Yin-Yang of TNF and Type I Interferon. Frontiers in Immunology. 2018;9:2746. DOI:10.3389/fimmu.2018.02746. 
  53. Wikan N, Hankittichai P, Thaklaewphan P, Potikanond S, Nimlamool W. Oxyresveratrol Inhibits TNF-alpha-Stimulated Cell Proliferation in Human Immortalized Keratinocytes (HaCaT) by Suppressing AKT Activation. Pharmaceutics. 2021;14(1):63. DOI:10.3390/pharmaceutics14010063. 
  54. Song YI, Oh MS. Anti-inflammatory Effect of Gyulpidaehwangbakcho-tang (Jupidahuangpoxiaotang) in the Collagen-induced Arthritis Mouse Model. Journal of Korean Medicine. 2011;32(6):18-29. 
  55. Sohn YJ, Kang HC, Kim KS, Park SM, Sohn NW, Jung HS, Kim SH. Protective effects of natrii sulfas on cerebral focal ischemia induced by MCAO in rats. The American Journal of Chinese Medicine. 2009; 37(02):273-93. DOI:10.1142/S0192415X09006849. 
  56. Kim KS, Kim BH, Lee DE, Kim SJ, Kang H, Sohn NW, Yang KY. Effects of Purgative Action with Natrii Sulfas on Bax and HSP72 Expressions of the MCAO Rat Brain. Journal of Physiology & Pathology in Korean Medicine. 2009;23(4):818-24.