BMB Reports

생화학분자생물학회 (Korean Society for Biochemistry and Molecular Biology)
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Current status and future of gene engineering in livestock

  • Dong-Hyeok Kwon (Laboratory of Theriogenology, College of Veterinary Medicine, Research Institute for Veterinary Science, BK21 FOUR Future Veterinary Medicine Leading Education & Research Center, Seoul National University) ;
  • Gyeong-Min Gim (LARTBio Inc.) ;
  • Soo-Young Yum (LARTBio Inc.) ;
  • Goo Jang (Laboratory of Theriogenology, College of Veterinary Medicine, Research Institute for Veterinary Science, BK21 FOUR Future Veterinary Medicine Leading Education & Research Center, Seoul National University)
  • 투고 : 2023.09.25
  • 심사 : 2023.12.04
  • 발행 : 2024.01.31
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초록

The application of gene engineering in livestock is necessary for various reasons, such as increasing productivity and producing disease resistance and biomedicine models. Overall, gene engineering provides benefits to the agricultural and research aspects, and humans. In particular, productivity can be increased by producing livestock with enhanced growth and improved feed conversion efficiency. In addition, the application of the disease resistance models prevents the spread of infectious diseases, which reduces the need for treatment, such as the use of antibiotics; consequently, it promotes the overall health of the herd and reduces unexpected economic losses. The application of biomedicine could be a valuable tool for understanding specific livestock diseases and improving human welfare through the development and testing of new vaccines, research on human physiology, such as human metabolism or immune response, and research and development of xenotransplantation models. Gene engineering technology has been evolving, from random, time-consuming, and laborious methods to specific, time-saving, convenient, and stable methods. This paper reviews the overall trend of genetic engineering technologies development and their application for efficient production of genetically engineered livestock, and provides examples of technologies approved by the United States (US) Food and Drug Administration (FDA) for application in humans.

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과제정보

This study was financially supported by the National Research Foundation of Korea (NRF-2021R1F1A1051953) and the Materials/Parts Technology Development Program (20023353, Development of composite formulation with a sustained release [gene] for the treatment of companion animal sarcopenia) funded By the Ministry of Trade, Industry & Energy (MOTIE, Korea). All of the figures in this paper were created with BioRender. com.

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